Abstract: An instrument incorporating a refractometer for measuring parameters of a fluid such as a metalworking fluid, avoids impairment of measurement accuracy due to contact of entrained air and oil with a refractometer window by temporarily interrupting the flow of the fluid through a refractometer chamber and orienting the window so that air and oil will readily separate from the window during the interruption of flow. Continued flow of metalworking flow while refractive index measurements are taken can be achieved by the use of by-pass valving arrangements.

Abstract: In some embodiments, the early feasibility assessment (EFA) system generates a set of quantitative systems pharmacology (QSP) models using rule-based reasoning systems to efficiently assess the feasibility of therapeutic drug candidates. With each QSP model, the EFA system provides sets of parameters for the user to easily contrast and compare various scenarios to explore risk and uncertainty of developing the therapeutic drug candidate, while high-performance computing provides near real-time simulation of the scenarios. The EFA system performs 1-dimensional or 2-dimensional scans of parameters and output feasibility criteria including, for example, maximum inhibition, activation, and target engagement. The assessment results and key parameters values can be presented via a user interface of the EFA system which allows user interactions with, for example, dose-response and pharmacokinetic and pharmacodynamic (PK/PD) plots.

Abstract: Methods for treating liver disease and, in particular, fatty liver disease, by administering a composition comprising a mixture of a first monounsaturated fatty acid and a second monounsaturated fatty acid are provided herewith.

Abstract: In an effort in solving the difficulties with cleaning cationic metal processing fluids and/or emulsions, processes for cleaning a metal processing fluid which is substantially free of fatty acids is provided herein and includes treating the metal processing fluid with dissolved air floatation. Also provided are processes for deforming metals and removing suspended foreign matter from a contaminated metal processing fluid and/or emulsions which are substantially free of fatty acids is provided and include the use of DAF technology. In one embodiment, the process is performed in the absence of a filter. In another embodiment, the process is performed in the absence of a filter which is capable of removing suspended foreign material in the contaminated metal processing fluid.

Abstract: The present invention provides methods and systems useful for modeling the pharmacology of an activated binding polypeptide or activatable antibody in a mammalian subject.

Abstract: An instrument incorporating a refractometer for measuring parameters of a fluid such as a metalworking fluid, avoids impairment of measurement accuracy due to contact of entrained air and oil with a refractometer window by temporarily interrupting the flow of the fluid through a refractometer chamber and orienting the window so that air and oil will readily separate from the window during the interruption of flow. Continued flow of metalworking flow while refractive index measurements are taken can be achieved by the use of by-pass valving arrangements.

Abstract: Compositions comprising high concentration of monounsaturated fatty acids having low melting points and high iodine values and use of such compositions as dietary supplements, nutraceuticals or pharmaceuticals for reducing atherosclerotic plaque in mammals. It has been found that high concentrations of monounsaturated fatty acids (MUFAs) having low melting point temperatures and iodine values of about 50 to about 130 can be used to effectively treat atherosclerosis. Epidemiological studies suggest that those populations consuming large quantities of C18:1 found in olive oil are protected against vascular diseases such as atherosclerosis.

Abstract: Compositions comprising high concentration of monounsaturated fatty acids having low melting points and high iodine values and use of such compositions as dietary supplements, nutraceuticals or pharmaceuticals for reducing atherosclerotic plaque in mammals. It has been found that high concentrations of monounsaturated fatty acids (MUFAs) having low melting point temperatures and iodine values of about 50 to about 130 can be used to effectively treat atherosclerosis. Epidemiological studies suggest that those populations consuming large quantities of C18:1 found in olive oil are protected against vascular diseases such as atherosclerosis.

Abstract: In an effort in solving the difficulties with cleaning cationic metal processing fluids and/or emulsions, processes for cleaning a metal processing fluid which is substantially free of fatty acids is provided herein and includes treating the metal processing fluid with dissolved air floatation. Also provided are processes for deforming metals and removing suspended foreign matter from a contaminated metal processing fluid and/or emulsions which are substantially free of fatty acids is provided and include the use of DAF technology. In one embodiment, the process is performed in the absence of a filter. In another embodiment, the process is performed in the absence of a filter which is capable of removing suspended foreign material in the contaminated metal processing fluid.

Abstract: Techniques are provided for synchronizing a wakeup schedule for a first module and a wakeup schedule for a CDMA module in a wireless mobile unit operable in a synchronous communication system. In one embodiment, a next CDMA wakeup time is determined.

Abstract: Method for reducing power consumption in a multimode device is disclosed. The multimode device includes a COMM1 component and a COMM2 component. In one aspect, a COMM1 component may be a UWB component and a COMM2 component may be a CDMA component. According to a disclosed embodiment, the time for a next scheduled COMM1 wakeup process to be performed by a COMM1 module is established. Thereafter, if the next COMM1 wakeup process is scheduled to be performed before the next COMM2 wakeup process, a COMM2 wakeup process is synchronized to be performed by a COMM2 module at the same time as the next COMM1 wakeup process. Following, when the time arrives for the COMM1 module to perform the next COMM1 wakeup process, the COMM2 module also performs the COMM2 wakeup process.

Abstract: A portable electronic device or wireless communication device (WCD) has at least one provision for optional equipment or user services. Options are provided for a user in a menu selection for selection by the consumer of the options. The user selects the options for the particular WCD and the options are installed on delivery or prior to delivery, thereby providing the user with an initial selection of the options.

Abstract: Techniques are provided for synchronizing a wakeup schedule for a first module and a wakeup schedule for a CDMA module in a wireless mobile unit operable in a synchronous communication system. In one embodiment, a next CDMA wakeup time is determined. A new wakeup time for the first module can then be synchronized to a next CDMA wakeup time when a next CDMA wakeup time is earlier than a next wakeup time for the first module.

Abstract: Method for reducing power consumption in Bluetooth and CDMA modes of operation is disclosed. According to a disclosed embodiment, the time for a next scheduled CDMA wakeup process to be performed by a CDMA module is established. Thereafter, if the next CDMA wakeup process is scheduled to be performed before the next Bluetooth wakeup process, a Bluetooth wakeup process is synchronized to be performed by a Bluetooth module at the same time as the next CDMA wakeup process. Following, when the time arrives for the CDMA module to perform the next CDMA wakeup process, the Bluetooth module also performs the Bluetooth wakeup process.

Abstract: Method for reducing power consumption in Bluetooth and CDMA modes of operation is disclosed. According to a disclosed embodiment, the time for a next scheduled CDMA wakeup process to be performed by a CDMA module is established. Thereafter, if the next CDMA wakeup process is scheduled to be performed before the next Bluetooth wakeup process, a Bluetooth wakeup process is synchronized to be performed by a Bluetooth module at the same time as the next CDMA wakeup process. Following, when the time arrives for the CDMA module to perform the next CDMA wakeup process, the Bluetooth module also performs the Bluetooth wakeup process.

Abstract: Method for reducing power consumption in Bluetooth and CDMA modes of operation is disclosed. According to a disclosed embodiment, the time for a next scheduled CDMA wakeup process to be performed by a CDMA module is established. Thereafter, if the next CDMA wakeup process is scheduled to be performed before the next Bluetooth wakeup process, a Bluetooth wakeup process is synchronized to be performed by a Bluetooth module at the same time as the next CDMA wakeup process. Following, when the time arrives for the CDMA module to perform the next CDMA wakeup process, the Bluetooth module also performs the Bluetooth wakeup process.

Abstract: This invention describes novel photoactive ribonucleotides that contain photocrosslinking agents placed at specific internal positions within a ribonucleotide. The invention also provides methods for identifying novel, sequence-specific target molecules, using the photoactive ribonucleotides of the invention, as well as improved nucleic acid hybridization analysis methods.

Abstract: A caster assembly for engaging, lifting and roll transporting columns of support racks, such as warehouse pallet racks, for movement of the support racks, includes an adaptor bracket secured to a housing of the caster assembly for engaging holes arranged on a web portion of a two-lines-of-holes-type column. The adaptor bracket is secured to the housing using fasteners arranged through selectively spaced fastener holes through a front wall of the housing. For a line-of-holes single type column, the adaptor bracket can be removed and individual lugs can be secured to the selectively spaced holes of the housing which correspond to the hole spacing of the column. Thus, the same caster assembly can be adapted to engage a column of either type.

Abstract: A caster assembly for engaging, lifting and roll transporting columns of support racks, such as warehouse pallet racks, for movement of the support racks, includes an adaptor bracket secured to a housing of the caster assembly for engaging holes arranged on a web portion of a two-lines-of-holes-type column. The adaptor bracket is secured to the housing using fasteners arranged through selectively spaced fastener holes through a front wall of the housing. For a line-of-holes single type column, the adaptor bracket can be removed and individual lugs can be secured to the selectively spaced holes of the housing which correspond to the hole spacing of the column. Thus, the same caster assembly can be adapted to engage a column of either type.

Abstract: Ribozyme having a ligand binding site formed as a double-stranded RNA and a single-stranded loop, the ribozyme having enzymatic activity to cleave and/or ligate itself or a separate RNA molecule.