Patents by Inventor John M. Domagala

John M. Domagala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-Quinolones and naphthyridones as antibacterial agents
    Patent number: 5633264
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: May 27, 1997
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Isothiazolones
    Patent number: 5620997
    Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, John M. Domagala, Edward F. Elslager, Rocco D. Gogliotti, Terri S. Purchase, Joseph P. Sanchez, Bharat K. Trivedi
  • Antibacterial agents
    Patent number: 5585491
    Abstract: Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: December 17, 1996
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: John M. Domagala, Susan E. Hagen, John S. Kiely
  • Individual stereosiomers of 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
    Patent number: 5563155
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: October 8, 1996
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Coumarin derivatives as protease inhibitors and antiviral agents
    Patent number: 5510375
    Abstract: The present invention relates to novel coumarin derivatives and related compounds which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The coumarin derivatives are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized coumarins and of related structures.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: April 23, 1996
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Hagen, Elizabeth Lunney, Bradley D. Tait
  • Individual stereoisomers of intermediates of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
    Patent number: 5461165
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: October 24, 1995
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Intermediates for individual stereoisomers of 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones
    Patent number: 5344940
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: September 6, 1994
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Naphthyridine antibacterial agents
    Patent number: 5281612
    Abstract: Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: January 25, 1994
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
    Patent number: 5258528
    Abstract: Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
    Type: Grant
    Filed: October 26, 1992
    Date of Patent: November 2, 1993
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, John S. Kiely, Mel C. Schroeder
  • Quinolinecarboxylic acid antibacterial agents
    Patent number: 5256662
    Abstract: Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: October 26, 1993
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Mark J. Suto, William R. Turner
  • Quinolinecarboxylic acid antibacterial agents
    Patent number: 5175356
    Abstract: Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: December 29, 1992
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Mark J. Suto, William R. Turner
  • Quinolinecarboxylic acid antibacterial agents
    Patent number: 5116834
    Abstract: Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: May 26, 1992
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Mark J. Suto, William R. Turner
  • Antibacterial agents - II
    Patent number: 5097032
    Abstract: Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: March 17, 1992
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Joseph P. Sanchez
  • Antibacterial agents
    Patent number: 5081254
    Abstract: A novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation and the use thereof in treating bacterial infections.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: January 14, 1992
    Assignee: Warner-Lambert Company
    Inventors: Townley P. Culbertson, John M. Domagala, Susan E. Hagen, Joseph P. Sanchez
  • Quinolinecarboxylic acid antibacterial agents
    Patent number: 5047538
    Abstract: Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: September 10, 1991
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Mark J. Suto, William R. Turner
  • Quinolones as antibacterial agents
    Patent number: 4933335
    Abstract: A novel series of quinolone carboxylic acids for use as antibacterial agents are described. Methods for making the compounds, methods of using the compounds and compositions containing them are also described. Certain novel intermediates are also described.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: June 12, 1990
    Assignee: Warner-Lambert Company
    Inventors: Alexander J. Bridges, John M. Domagala
  • Antibacterial agents
    Patent number: 4929613
    Abstract: The novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation and the use thereof in treating bacterial infections.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: May 29, 1990
    Assignee: Warner-Lambert Company
    Inventors: Townley P. Culbertson, John M. Domagala, Susan E. Hagen, Joseph P. Sanchez
  • Antibacterial agents
    Patent number: 4920120
    Abstract: Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: April 24, 1990
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Hagen, John S. Kiely
  • Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
    Patent number: 4840956
    Abstract: Disubstituted 7-pyrrolidinoquinoline- and -napthylridine-3-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: June 20, 1989
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Hagen, Joseph P. Sanchez, Marjorie S. Solomon
  • 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
    Patent number: 4822801
    Abstract: Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: April 18, 1989
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Joseph P. Sanchez