Patents by Inventor John M. Domagala

John M. Domagala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinolones as antibacterial agents
    Patent number: 4803205
    Abstract: A novel series of quinolone carboxylic acids for use as antibacterial agents are described. Methods for making the compounds, methods of using the compounds and compositions containing them are also described. Certain novel intermediates are also described.
    Type: Grant
    Filed: June 7, 1988
    Date of Patent: February 7, 1989
    Assignee: Warner-Lambert Company
    Inventors: Alexander J. Bridges, John M. Domagala
  • 8-trifluoromethyl quinolones as antibacterial agents
    Patent number: 4780468
    Abstract: A novel series of quinolone carboxylic acids for use as antibacterial agents are described. Methods for making the compounds, methods of using the compounds and compositions containing them are also described. Certain novel intermediates are also described.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: October 25, 1988
    Assignee: Warner-Lambert Company
    Inventors: Alexander J. Bridges, John M. Domagala
  • Process for quinoline-3-carboxylic acid antibacterial agents
    Patent number: 4772706
    Abstract: An improved process for the preparation of 7-substituted amino-1-alkyl- or cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids is described where tetrafluorobenzoyl chloride is converted in three operations via 1-alkyl or 1-cycloalkyl-1,4-dihydro-6,7,8-trifluoro-4-oxoquinoline-3-carbonitrile which in a separate step or in situ is displaced and hydrolyzed to the desired product.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: September 20, 1988
    Assignee: Warner-Lambert Company
    Inventors: James N. Wemple, James R. Zeller, John M. Domagala
  • 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
    Patent number: 4771055
    Abstract: Novel, orally active antibacterial agents are described and characterized as 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo -3-quinoline carboxylic acids or corresponding 1,8-naphthyridine derivatives as well as methods for their manufacture.
    Type: Grant
    Filed: April 21, 1987
    Date of Patent: September 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Hagen, Joseph P. Sanchez
  • Antibacterial agents
    Patent number: 4771054
    Abstract: Novel quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: September 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
    Patent number: 4735949
    Abstract: Disubstituted 7-pyrrolidinoquinoline- and -naphthyridine-3-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: April 5, 1988
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Prugh, Joseph P. Sanchez, Marjorie S. Solomon
  • Antibacterial agents
    Patent number: 4665079
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: January 23, 1985
    Date of Patent: May 12, 1987
    Assignee: Warner-Lambert Company
    Inventors: Townley P. Culbertson, John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine -3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines
    Patent number: 4663457
    Abstract: 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their esters, which are useful as intermediates for the preparation of compounds which are useful as anti-bacterial agents.
    Type: Grant
    Filed: August 13, 1985
    Date of Patent: May 5, 1987
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Joseph P. Sanchez, John M. Domagala, Ashok K. Trehan
  • Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
    Patent number: 4657913
    Abstract: Novel difluoro-naphthyridine- and trifluoroquinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: April 18, 1985
    Date of Patent: April 14, 1987
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, John M. Domagala, Jeffrey B. Nichols
  • Antibacterial agents
    Patent number: 4638067
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: January 20, 1987
    Assignee: Warner-Lambert Co.
    Inventors: Townley P. Culbertson, John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents
    Patent number: 4617308
    Abstract: Novel 1-aryl or heteroaryl-6,8-difluoro-1,4-dihydro-7-(3-aminomethyl)pyrrolidinyl- or 7-spiroamino-4-oxo-3-quinolinecarboxylic acids and acid derivatives thereof as antibacterial agents are described as well as methods for their manufacture, formulation and use in treating bacterial infections caused by Gram-negative and Gram-positive bacteria.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: October 14, 1986
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, John M. Domagala
  • Antibacterial agents III
    Patent number: 4604401
    Abstract: Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: August 5, 1986
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Townley P. Culbertson, John M. Domagala
  • Process for quinoline-3-carboxylic acid antibacterial agents
    Patent number: 4578473
    Abstract: An improved process for the preparation of 7-substituted amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids is described where an alkyl ester of a 6,7,8-trifluoro precursor is converted to a trialkylsilyl ester which fluorine at C.sub.7 is directly displaced to the desired product.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: March 25, 1986
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Mel C. Schroeder