Patents by Inventor John M. Perry

John M. Perry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING CHEMORESISTANT CANCER-INITIATING CELLS
    Publication number: 20220105114
    Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-?-catenin, p-T217-?-catenin, T332-?-catenin, and/or p-S675-?-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
    Type: Application
    Filed: October 12, 2021
    Publication date: April 7, 2022
    Inventors: Rajeswari KASI, Linheng Ll, Xiuling LU, John M. PERRY, Gurusingham Sitta SITTAMPALAM, Anuradha ROY, Xi C. HE
  • Methods for treating chemoresistant cancer-initiating cells
    Patent number: 11173173
    Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-?-catenin, p-T217-?-catenin, p-T332-?-catenin, and/or p-S675-?-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: November 16, 2021
    Assignees: UNIVERSITY OF CONNECTICUT, UNIVERSITY OF KANSAS, STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Rajeswari Kasi, Linheng Li, Xiuling Lu, John M. Perry, Gurusingham Sitta Sittampalam, Anuradha Roy, Xi C. He
  • METHODS FOR OVERCOMING WNT/BETA-CATENIN ANTI-CANCER RESISTANCE IN LEUKEMIA STEM CELLS
    Publication number: 20210113597
    Abstract: The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.
    Type: Application
    Filed: June 26, 2020
    Publication date: April 22, 2021
    Inventors: Linheng Li, John M. Perry, Fang Tao, Xi C. He, Anuradha Roy, Scott J. Weir, Tara Lin
  • Methods, kits, and compositions for stem cell self-renewal
    Patent number: 10787643
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: September 29, 2020
    Assignee: STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • METHODS FOR TREATING CHEMORESISTANT CANCER-INITIATING CELLS
    Publication number: 20180207184
    Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-?-catenin, p-T217-?-catenin, p-T332-?-catenin, and/or p-S675-?-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
    Type: Application
    Filed: July 28, 2016
    Publication date: July 26, 2018
    Inventors: Rajeswari KASI, Linheng Ll, Xiuling LU, John M. PERRY, Gurusingham Sitta SITTAMPALAM, Anuradha ROY, Xi C. HE
  • METHODS AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
    Publication number: 20180072991
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: August 22, 2017
    Publication date: March 15, 2018
    Inventors: John M. PERRY, Linheng LI, Justin C. GRINDLEY
  • Methods, kits, and compositions for stem cell self-renewal
    Patent number: 9896659
    Abstract: Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: February 20, 2018
    Assignee: STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: John M Perry, Linheng Li, Aparna Venkatraman, Xi He
  • Methods and compositions for stem cell self-renewal
    Patent number: 9771559
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: September 26, 2017
    Assignee: Stowers Institute for Medical Research
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Methods, Kits, and Compositions for Stem Cell Self-Renewal
    Publication number: 20160355784
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: May 17, 2016
    Publication date: December 8, 2016
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Load switch having load detection
    Patent number: 9350180
    Abstract: Conventionally, current detection in load switches is implemented by monitoring the voltage across a small value sense resistor in series with the load switch, where the differential voltage across is applied to a comparator to generate a control signal corresponding to a light load condition, a normal load condition, or an over-load condition. Detecting the light load condition, however, can be difficult to determine using this arrangement due to the low differential voltage. Here, however, a integrated circuit (IC) is provided that employs an internal voltage supply and comparators to examine the load current to determine whether a light load condition is present, which does not suffer from the same problems.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 24, 2016
    Assignee: Texas Instruments Incorporated
    Inventors: Christopher T. Maxwell, John M. Perry, Aline C. Sadate, James C. Spurlin, Nakshatra S. Gajbhiye
  • METHODS, KITS, AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
    Publication number: 20150344845
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: February 27, 2015
    Publication date: December 3, 2015
    Inventors: John M. Perry, Linheng Li, Justin Campos Grindley
  • METHODS, KITS, AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
    Publication number: 20140255359
    Abstract: Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.
    Type: Application
    Filed: October 17, 2012
    Publication date: September 11, 2014
    Inventors: John M. Perry, Linheng Li, Aparna Venkatraman, Xi He
  • METHODS AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
    Publication number: 20130252338
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: May 20, 2013
    Publication date: September 26, 2013
    Applicant: Stowers Institute for Medical Research
    Inventors: John M. PERRY, Linheng LI, Justin C. GRINDLEY
  • Methods and compositions for stem cell self-renewal
    Patent number: 8476071
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 2, 2013
    Assignee: Stowers Institute for Medical Research
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • METHODS AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
    Publication number: 20120309088
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: August 9, 2012
    Publication date: December 6, 2012
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • LOAD SWITCH HAVING LOAD DETECTION
    Publication number: 20120274153
    Abstract: Conventionally, current detection in load switches is implemented by monitoring the voltage across a small value sense resistor in series with the load switch, where the differential voltage across is applied to a comparator to generate a control signal corresponding to a light load condition, a normal load condition, or an over-load condition. Detecting the light load condition, however, can be difficult to determine using this arrangement due to the low differential voltage. Here, however, a integrated circuit (IC) is provided that employs an internal voltage supply and comparators to examine the load current to determine whether a light load condition is present, which does not suffer from the same problems.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 1, 2012
    Applicant: Texas Instruments Incorporated
    Inventors: Christopher T. Maxwell, John M. Perry, Aline C. Sadate, James C. Spurlin, Nakshatra S. Gajbhiye
  • Methods and compositions for stem cell self-renewal
    Patent number: 8263403
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: September 11, 2012
    Assignee: Stowers Institute for Medical Research
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Methods, kits, and compositions for stem cell self-renewal
    Publication number: 20110053266
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: June 16, 2010
    Publication date: March 3, 2011
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • METHODS AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL
    Publication number: 20100196337
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: April 23, 2008
    Publication date: August 5, 2010
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Methods, kits, and compositions for stem cell self-renewal
    Publication number: 20100099186
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Application
    Filed: October 23, 2009
    Publication date: April 22, 2010
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley