Patents by Inventor John McDonald

John McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160046634
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention further provides for pharmaceutically acceptable compositions comprising therapeutically effective amounts of one or more of the protein kinase inhibitor compounds and methods of using said compositions in the treatment of cancers and carcinomas.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Laura Akullian D'Agostino, Robert Tjin Tham Sjin, Deqiang Niu, Joseph John McDonald, Zhendong Zhu, Haibo Liu, Hormoz Mazdiyasni, Russell C. Petter, Juswinder Singh, Matthieu Barrague, Alexandre Gross, Mark Munson, Darren Harvey, Andrew Scholte, Sachin Maniar
  • Publication number: 20150376208
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 14, 2014
    Publication date: December 31, 2015
    Applicant: Celgene Avilomics Research, Inc.
    Inventors: Matthew David ALEXANDER, Joseph John MCDONALD, Yike NI, Deqiang NIU, Russell C. PETTER, Lixin QIAO, Juswinder SINGH, Tao WANG, Zhendong ZHU
  • Patent number: 9222668
    Abstract: A burner apparatus for a furnace system and a method of burner operation. The burner has a series of fuel ejection structures which at least partially surround the burner wall for ejecting fuel into a combustion region projecting from the forward end of the burner wall. The ejection structures preferably eject fuel outside of the burner wall at alternating angles. Further, the burner apparatus preferably includes at least one additional series of fuel ejection structures which is spaced radially outward from the first series of ejection structures.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: December 29, 2015
    Assignee: ZEECO, INC.
    Inventors: Darton J. Zink, Rex K. Isaacs, John Philip Guarco, Frank E. Beale, John McDonald, Cody L. Little, Seth Marty, Ryan Roberts
  • Publication number: 20150354811
    Abstract: A burner apparatus for a furnace system and a method of burner operation wherein a non-symmetrical positioning of one combustion fuel discharge tip or a grouping of fuel discharge tips within the burner wall produces side-by-side lean and fuel rich combustion stage zones and also produces internal flue gas recirculation.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 10, 2015
    Inventors: Darton J. Zink, Rex K. Isaacs, Parker Imel, Seth Marty, Jonathon Barnes, Cody Little, John McDonald, Tim Kirk, Tim Minihan
  • Patent number: 9199761
    Abstract: A packaging container can be configured to include cushioning material and to be foldable between an expanded state in which the container can be used to ship an article and a compressed state in which the container occupies a smaller volumetric space without the article being contained therein. This can reduce shipping costs associated with transporting the empty container.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: December 1, 2015
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Publication number: 20150266642
    Abstract: A packaging device can include a resilient member formed of one or more layers of different materials and a frame member. The resilient member can be heat sealed to the frame member or to a coating on the surface of the frame member. The layers can be made from different materials or the same materials having different thicknesses, modules of elasticity, melting index, or other different characteristics.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 24, 2015
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Publication number: 20150266639
    Abstract: A packaging device can include a flexible member which can be resilient, substantially non-resilient, or non-resilient, which can be formed of one or more layers which can be different materials and a frame member. The flexible member can be heat sealed to the frame member or to a coating on the surface of the frame member. The layers can be made from different materials or the same materials having different thicknesses, modules of elasticity, melting index, or other different characteristics.
    Type: Application
    Filed: March 18, 2015
    Publication date: September 24, 2015
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Publication number: 20150239635
    Abstract: A packaging device can include a retention member formed of two layers that are different from one another. In some embodiments, the two layers are made of different material, connected together such as by heat sealing. The layers can be made from different materials or the same materials having different thicknesses, modules of elasticity, melting index, or other different characteristics. In some embodiments, the two layers have different physical dimensions.
    Type: Application
    Filed: September 13, 2013
    Publication date: August 27, 2015
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Patent number: 9108858
    Abstract: A Haber-Bosch process including the steps of providing a reactor having a substrate with catalyst filaments formed thereon. The catalyst filaments are formed of a metal including iron. A nitrogen compound and hydrogen are injected into the reactor such that at least a portion of the nitrogen compound and hydrogen contact the catalyst filaments. The nitrogen compound and hydrogen are reacted with the catalyst filaments at a temperature of less than about 600° F. and a pressure of less than about 2000 psig.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: August 18, 2015
    Assignee: Louisiana Tech University Research Foundation; a Division of Louisiana Tech University Foundation
    Inventors: John McDonald, Chester Wilson, Joshua Brown
  • Patent number: 9067722
    Abstract: A packaging device can include a resilient member formed of two layers of different material, connected together such as by heat sealing. The layers can be made from different materials or the same materials having different thicknesses, modules of elasticity, melting index, or other different characteristics.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 30, 2015
    Assignee: CLEARPAK, LLC
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Publication number: 20150125517
    Abstract: The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).
    Type: Application
    Filed: November 12, 2014
    Publication date: May 7, 2015
    Inventors: John McDonald, Nathan John Bowen, LiJuan Wang
  • Publication number: 20150114875
    Abstract: A packaging container can be configured to include cushioning material and to be foldable between an expanded state in which the container can be used to ship an article and a compressed state in which the container occupies a smaller volumetric space without the article being contained therein. This can reduce shipping costs associated with transporting the empty container.
    Type: Application
    Filed: October 28, 2013
    Publication date: April 30, 2015
    Applicant: ClearPak, LLC
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Publication number: 20150114876
    Abstract: A packaging container can be configured to include cushioning material and to be foldable between an expanded state in which the container can be used to ship an article and a compressed state in which the container occupies a smaller volumetric space without the article being contained therein. This can reduce shipping costs associated with transporting the empty container.
    Type: Application
    Filed: November 21, 2013
    Publication date: April 30, 2015
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Publication number: 20150071843
    Abstract: A Haber-Bosch process including the steps of providing a reactor having a substrate with catalyst filaments formed thereon. The catalyst filaments are formed of a metal including iron. A nitrogen compound and hydrogen are injected into the reactor such that at least a portion of the nitrogen compound and hydrogen contact the catalyst filaments. The nitrogen compound and hydrogen are reacted with the catalyst filaments at a temperature of less than about 600° F. and a pressure of less than about 2000 psig.
    Type: Application
    Filed: November 18, 2014
    Publication date: March 12, 2015
    Inventors: Chester Wilson, John McDonald, Joshua Brown
  • Publication number: 20150054843
    Abstract: A color-correct alpha blending texture filter and a method of texture filtering. One embodiment of the color-correct alpha blending texture filter includes: (1) an alpha blender configured to receive a post-multiplied pixel color and convert to a pre-multiplied pixel color, and (2) a filter configured to apply texture filtering to the plurality of pixels based on pre-multiplied pixel colors.
    Type: Application
    Filed: August 20, 2013
    Publication date: February 26, 2015
    Applicant: Nvidia Corporation
    Inventors: John McDonald, Cass Everitt
  • Publication number: 20140360913
    Abstract: A packaging assembly can include a container comprising a top, a bottom and a plurality of sidewalls, a first frame and a second frame. The first frame can include a first support panel including a first surface configured to face an article and a second surface opposite to the first surface, and a first leg portion pivotably connected to the first support panel and located between the first support panel and the bottom. The first leg portion can cause a resilient force to bias the first support panel away from the bottom when the first leg portion is located at a third rotational position between the first rotational position and the second rotational position. The second frame can include a second support panel. The second frame can nest with the first frame within the container so as to retain an article between the first and second support panels.
    Type: Application
    Filed: January 13, 2014
    Publication date: December 11, 2014
    Applicant: Clearpak, LLC
    Inventors: John McDonald, Frank Comerford, Myles Comerford
  • Patent number: 8895631
    Abstract: A Fischer-Tropsch process including the steps of providing a reactor having a substrate element with a surface and a plurality of elongated micro-structures of catalyst material attached to the substrate surface The catalyst material includes at least one of cobalt, iron, or ruthenium and the micro-structures have a width of less than about 1 um and a length at least five times the width. A carbon compound and hydrogen are injected into the reactor such that at least a portion of the carbon compound and hydrogen contact the catalyst material. The carbon compound and hydrogen are reacted with the catalyst at a temperature between about 150° F. and about 400° F.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: November 25, 2014
    Assignee: Louisiana Tech University Research Foundation; a division of Louisiana Tech University Foundation, Inc.
    Inventors: Chester Wilson, John McDonald, Joshua Brown
  • Patent number: 8895509
    Abstract: The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: November 25, 2014
    Assignee: Georgia Tech Research Corporation
    Inventors: John McDonald, Nathan John Bowen, LiJuan Wang
  • Publication number: 20140309186
    Abstract: A method, computer-readable medium, and system for identifying one or more metabolites associated with a disease, comprising: comparing gene expression data from diseased cells to gene expression data from control cells in order to deduce genes that are differentially-regulated in the diseased cells relative to the control cells; based on enzyme function and pathway data for all human metabolites that utilize the genes that are differentially-regulated in the disease cells, identifying one or more metabolites whose intracellular levels are higher or lower in diseased cells than in control cells, and thereby associating the one or more metabolites with the disease.
    Type: Application
    Filed: June 24, 2014
    Publication date: October 16, 2014
    Inventors: Jeffrey Skolnick, Adrian K. Arakaki, John McDonald, Roman Mezencev, Nathan Bowen
  • Publication number: 20140296233
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicants: Sanofi, Celgene Avilomics Research, Inc.
    Inventors: Laura Akullian D'Agostino, Robert Tjin Tham Sjin, Deqiang Niu, Joseph John McDonald, Zhendong Zhu, Haibo Liu, Hormoz Mazdiyasni, Russell C. Petter, Juswinder Singh, Matthieu Barrague, Alexandre Gross, Mark Munson