Patents by Inventor John McLean
John McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10607721Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.Type: GrantFiled: September 22, 2016Date of Patent: March 31, 2020Assignee: VANDERBILT UNIVERSITYInventors: Richard Caprioli, John Wikswo, John McLean, Eric Skaar, Jeremy L. Norris, Dana Borden Lacy, Stacy Sherrod, James Pino, Danielle Gutierrez, Nicole D. Muszynski, Melissa Farrow
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Publication number: 20190357649Abstract: People carry electronic devices on their person which have cases to protect electronic devices from falls. People also carry a variety of tools on their persons. Existing cases rarely have integrated tools and when they do the utility of the case and the tool are both reduced. The present invention is a protective case for electronic devices which securely stores tools inside the case. The tools are fully removable from the case. The tools are retained in the case by geometric interference between the tool and the case.Type: ApplicationFiled: May 26, 2019Publication date: November 28, 2019Applicant: Knyphe, LLCInventors: Charles Joseph Becnel, Jeffrey John McLean
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Publication number: 20190183288Abstract: The present invention relates to a cooker such as a barbeque. The cooker includes a support for supporting a cooking member such as a hotplate or grill. A burner is provided for being sheltered by the support and for burning gas to form flames. The burner is preferably sheltered by the support to impede dripping grease or fat, from the cooking member, from accumulating on the burners during cooking to thereby reduce cleaning when compared with known barbeques.Type: ApplicationFiled: August 18, 2017Publication date: June 20, 2019Inventors: Phillip Brown, Robert John McLean
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Publication number: 20180339058Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: ApplicationFiled: July 30, 2018Publication date: November 29, 2018Applicant: Wyeth Holdings LLCInventors: Arthur KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
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Publication number: 20170082606Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.Type: ApplicationFiled: September 22, 2016Publication date: March 23, 2017Applicant: Vanderbilt UniversityInventors: Richard CAPRIOLI, John WIKSWO, John MCLEAN, Eric SKAAR, Jeremy L. Norris
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Publication number: 20170030606Abstract: A system and method for determining at least one climate energy index, comprising: at least one server and/or at least one client coupled to at least one application, the at least one application capable of: identifying at least one geographic location; identifying at least one human comfort zone; performing at least one energy calculation for weather ordinates associated with the at least one geographic location and the at least one human comfort zone; summing the at least one energy calculation for at least one time period; combining all the energy calculations to produce at least one energy total for the at least one geographic location; and determining at least one first index value associated with delivered energy based on the at least one energy total for the at least one geographic location.Type: ApplicationFiled: October 13, 2016Publication date: February 2, 2017Applicant: INTEGRATED ENVIRONMENTAL SOLUTIONS, LTD.Inventor: Donald John MCLEAN
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Patent number: 9501805Abstract: Methods and systems for optimizing a building design. A geographic location and a human comfort zone are identified. It is determined whether to adjust the building design based on information comprising building simulated delivered energy data and whether the building design meets pre-determined comfort conditions.Type: GrantFiled: August 2, 2013Date of Patent: November 22, 2016Assignee: INTEGRATED ENVIORNMENTALSOLUTIONS, LTD.Inventor: Donald John McLean
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Publication number: 20160303252Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: ApplicationFiled: May 3, 2016Publication date: October 20, 2016Applicant: Wyeth Holdings LLCInventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
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Patent number: 9351986Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: GrantFiled: March 7, 2014Date of Patent: May 31, 2016Assignee: WYETH HOLDINGS LLCInventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
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Patent number: 8835611Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: GrantFiled: February 13, 2012Date of Patent: September 16, 2014Assignee: Wyeth Holdings LLCInventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Paul David Robbins, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Andrew George Popplewell
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Publication number: 20140235835Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: ApplicationFiled: March 7, 2014Publication date: August 21, 2014Applicant: WYETH HOLDINGS LLCInventors: ARTHUR KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
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Patent number: 8747857Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: GrantFiled: November 3, 2003Date of Patent: June 10, 2014Assignee: Wyeth Holdings LLCInventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
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Publication number: 20140039832Abstract: A system and method for determining at least one climate energy index, comprising: at least one server and/or at least one client coupled to at least one application, the at least one application capable of: identifying at least one geographic location; identifying at least one human comfort zone; performing at least one energy calculation for weather ordinates associated with the at least one geographic location and the at least one human comfort zone; summing the at least one energy calculation for at least one time period; combining all the energy calculations to produce at least one energy total for the at least one geographic location; and determining at least one first index value associated with delivered energy based on the at least one energy total for the at least one geographic location.Type: ApplicationFiled: August 2, 2013Publication date: February 6, 2014Applicant: INTEGRATED ENVIRONMENTAL SOLUTIONS, LTD.Inventor: DONALD JOHN MCLEAN
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Patent number: 8532835Abstract: A system and method for determining a climate energy index, comprising: identifying a geographic location; identifying comfort zone criteria; determining a characteristic energy potential associated with the geographic location and the comfort zone criteria, and determining a climate energy index associated with delivered energy based on the characteristic energy potential for the geographic location.Type: GrantFiled: April 29, 2010Date of Patent: September 10, 2013Assignee: Integrated Environmental Solutions, Ltd.Inventor: Donald John McLean
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Patent number: 8402434Abstract: There is disclosed a method and system for generating documentation for a GUI usage scenario. There is also disclosed a method and system for assembling a GUI script from a plurality of pre-scripted parts. In an embodiment, shadow objects are created to listen to and report activities of each GUI object of interest during a GUI usage session. The shadow objects may listen to shadowed GUI object activities during playback of the GUI script, or during a live GUI usage session. GUI object activities reported by the shadow objects are identified and converted into narrative language statements, using a pre-determined conversion list, to create human-readable documentation.Type: GrantFiled: October 21, 2008Date of Patent: March 19, 2013Assignee: International Business Machines CorporationInventor: Alan John McLean
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Publication number: 20120271784Abstract: A system and method of analysis, including, but not limited to: receiving raw data related to at least one project; receiving user preferences in at least one workflow, and determining metrics related to the, at least one project.Type: ApplicationFiled: April 5, 2012Publication date: October 25, 2012Applicant: INTEGRATED ENVIRONMENTAL SOLUTIONS, LTD.Inventors: Donald John McLEAN, Richard John QUINCEY
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Publication number: 20120213804Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.Type: ApplicationFiled: February 13, 2012Publication date: August 23, 2012Applicant: WYETH HOLDINGS CORPORATIONInventors: ARTHUR KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Paul David Robbins, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Andrew George Popplewell
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Publication number: 20120137747Abstract: A die apparatus for forging a steering rack from a bar. The die apparatus comprises a first and a second bolster movable towards each other, and at least one gripper adapted to grip the bar as the rack is forged. The gripper comprises first and second gripper halves carried by, and movable relative to, the first and second bolsters respectively. A gripper bias means biases the gripper halves towards each other. As the bolsters move towards each other to forge the rack, the first gripper half abuts against the first bolster, and the second gripper half abuts the second bolster.Type: ApplicationFiled: July 28, 2010Publication date: June 7, 2012Inventors: Wayne Bruce Cornish, Lyle John McLean
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Patent number: 8180727Abstract: A system and method of navigating modeling of a building, including: receiving nonparametric user input building design data, organizing the nonparametric user input building design data, and globally editing the non-parametric data element in multiple objects within a building design.Type: GrantFiled: February 17, 2011Date of Patent: May 15, 2012Assignee: Integrated Environmental Solutions, Ltd.Inventors: Donald John McLean, Richard John Quincey
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Patent number: D908131Type: GrantFiled: September 24, 2019Date of Patent: January 19, 2021Assignee: XPO Technologies Inc.Inventors: Andrew John Mclean, Matthew Hunsberger