Patents by Inventor John McLean

John McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10607721
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 31, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, John Wikswo, John McLean, Eric Skaar, Jeremy L. Norris, Dana Borden Lacy, Stacy Sherrod, James Pino, Danielle Gutierrez, Nicole D. Muszynski, Melissa Farrow
  • Publication number: 20190357649
    Abstract: People carry electronic devices on their person which have cases to protect electronic devices from falls. People also carry a variety of tools on their persons. Existing cases rarely have integrated tools and when they do the utility of the case and the tool are both reduced. The present invention is a protective case for electronic devices which securely stores tools inside the case. The tools are fully removable from the case. The tools are retained in the case by geometric interference between the tool and the case.
    Type: Application
    Filed: May 26, 2019
    Publication date: November 28, 2019
    Applicant: Knyphe, LLC
    Inventors: Charles Joseph Becnel, Jeffrey John McLean
  • Publication number: 20190183288
    Abstract: The present invention relates to a cooker such as a barbeque. The cooker includes a support for supporting a cooking member such as a hotplate or grill. A burner is provided for being sheltered by the support and for burning gas to form flames. The burner is preferably sheltered by the support to impede dripping grease or fat, from the cooking member, from accumulating on the burners during cooking to thereby reduce cleaning when compared with known barbeques.
    Type: Application
    Filed: August 18, 2017
    Publication date: June 20, 2019
    Inventors: Phillip Brown, Robert John McLean
  • Publication number: 20180339058
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 29, 2018
    Applicant: Wyeth Holdings LLC
    Inventors: Arthur KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Publication number: 20170082606
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Application
    Filed: September 22, 2016
    Publication date: March 23, 2017
    Applicant: Vanderbilt University
    Inventors: Richard CAPRIOLI, John WIKSWO, John MCLEAN, Eric SKAAR, Jeremy L. Norris
  • Publication number: 20170030606
    Abstract: A system and method for determining at least one climate energy index, comprising: at least one server and/or at least one client coupled to at least one application, the at least one application capable of: identifying at least one geographic location; identifying at least one human comfort zone; performing at least one energy calculation for weather ordinates associated with the at least one geographic location and the at least one human comfort zone; summing the at least one energy calculation for at least one time period; combining all the energy calculations to produce at least one energy total for the at least one geographic location; and determining at least one first index value associated with delivered energy based on the at least one energy total for the at least one geographic location.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Applicant: INTEGRATED ENVIRONMENTAL SOLUTIONS, LTD.
    Inventor: Donald John MCLEAN
  • Patent number: 9501805
    Abstract: Methods and systems for optimizing a building design. A geographic location and a human comfort zone are identified. It is determined whether to adjust the building design based on information comprising building simulated delivered energy data and whether the building design meets pre-determined comfort conditions.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: November 22, 2016
    Assignee: INTEGRATED ENVIORNMENTALSOLUTIONS, LTD.
    Inventor: Donald John McLean
  • Publication number: 20160303252
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: May 3, 2016
    Publication date: October 20, 2016
    Applicant: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 9351986
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 31, 2016
    Assignee: WYETH HOLDINGS LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 8835611
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: September 16, 2014
    Assignee: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Paul David Robbins, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Andrew George Popplewell
  • Publication number: 20140235835
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: March 7, 2014
    Publication date: August 21, 2014
    Applicant: WYETH HOLDINGS LLC
    Inventors: ARTHUR KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 8747857
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: June 10, 2014
    Assignee: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Publication number: 20140039832
    Abstract: A system and method for determining at least one climate energy index, comprising: at least one server and/or at least one client coupled to at least one application, the at least one application capable of: identifying at least one geographic location; identifying at least one human comfort zone; performing at least one energy calculation for weather ordinates associated with the at least one geographic location and the at least one human comfort zone; summing the at least one energy calculation for at least one time period; combining all the energy calculations to produce at least one energy total for the at least one geographic location; and determining at least one first index value associated with delivered energy based on the at least one energy total for the at least one geographic location.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 6, 2014
    Applicant: INTEGRATED ENVIRONMENTAL SOLUTIONS, LTD.
    Inventor: DONALD JOHN MCLEAN
  • Patent number: 8532835
    Abstract: A system and method for determining a climate energy index, comprising: identifying a geographic location; identifying comfort zone criteria; determining a characteristic energy potential associated with the geographic location and the comfort zone criteria, and determining a climate energy index associated with delivered energy based on the characteristic energy potential for the geographic location.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: September 10, 2013
    Assignee: Integrated Environmental Solutions, Ltd.
    Inventor: Donald John McLean
  • Patent number: 8402434
    Abstract: There is disclosed a method and system for generating documentation for a GUI usage scenario. There is also disclosed a method and system for assembling a GUI script from a plurality of pre-scripted parts. In an embodiment, shadow objects are created to listen to and report activities of each GUI object of interest during a GUI usage session. The shadow objects may listen to shadowed GUI object activities during playback of the GUI script, or during a live GUI usage session. GUI object activities reported by the shadow objects are identified and converted into narrative language statements, using a pre-determined conversion list, to create human-readable documentation.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: March 19, 2013
    Assignee: International Business Machines Corporation
    Inventor: Alan John McLean
  • Publication number: 20120271784
    Abstract: A system and method of analysis, including, but not limited to: receiving raw data related to at least one project; receiving user preferences in at least one workflow, and determining metrics related to the, at least one project.
    Type: Application
    Filed: April 5, 2012
    Publication date: October 25, 2012
    Applicant: INTEGRATED ENVIRONMENTAL SOLUTIONS, LTD.
    Inventors: Donald John McLEAN, Richard John QUINCEY
  • Publication number: 20120213804
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: February 13, 2012
    Publication date: August 23, 2012
    Applicant: WYETH HOLDINGS CORPORATION
    Inventors: ARTHUR KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Paul David Robbins, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Andrew George Popplewell
  • Publication number: 20120137747
    Abstract: A die apparatus for forging a steering rack from a bar. The die apparatus comprises a first and a second bolster movable towards each other, and at least one gripper adapted to grip the bar as the rack is forged. The gripper comprises first and second gripper halves carried by, and movable relative to, the first and second bolsters respectively. A gripper bias means biases the gripper halves towards each other. As the bolsters move towards each other to forge the rack, the first gripper half abuts against the first bolster, and the second gripper half abuts the second bolster.
    Type: Application
    Filed: July 28, 2010
    Publication date: June 7, 2012
    Inventors: Wayne Bruce Cornish, Lyle John McLean
  • Patent number: 8180727
    Abstract: A system and method of navigating modeling of a building, including: receiving nonparametric user input building design data, organizing the nonparametric user input building design data, and globally editing the non-parametric data element in multiple objects within a building design.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: May 15, 2012
    Assignee: Integrated Environmental Solutions, Ltd.
    Inventors: Donald John McLean, Richard John Quincey
  • Patent number: D908131
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: January 19, 2021
    Assignee: XPO Technologies Inc.
    Inventors: Andrew John Mclean, Matthew Hunsberger