Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Abstract: A system and method for determining at least one climate energy index, comprising: at least one server and/or at least one client coupled to at least one application, the at least one application capable of: identifying at least one geographic location; identifying at least one human comfort zone; performing at least one energy calculation for weather ordinates associated with the at least one geographic location and the at least one human comfort zone; summing the at least one energy calculation for at least one time period; combining all the energy calculations to produce at least one energy total for the at least one geographic location; and determining at least one first index value associated with delivered energy based on the at least one energy total for the at least one geographic location.

Abstract: A system and method for determining a climate energy index, comprising: identifying a geographic location; identifying comfort zone criteria; determining a characteristic energy potential associated with the geographic location and the comfort zone criteria, and determining a climate energy index associated with delivered energy based on the characteristic energy potential for the geographic location.

Abstract: There is disclosed a method and system for generating documentation for a GUI usage scenario. There is also disclosed a method and system for assembling a GUI script from a plurality of pre-scripted parts. In an embodiment, shadow objects are created to listen to and report activities of each GUI object of interest during a GUI usage session. The shadow objects may listen to shadowed GUI object activities during playback of the GUI script, or during a live GUI usage session. GUI object activities reported by the shadow objects are identified and converted into narrative language statements, using a pre-determined conversion list, to create human-readable documentation.

Abstract: A system and method of analysis, including, but not limited to: receiving raw data related to at least one project; receiving user preferences in at least one workflow, and determining metrics related to the, at least one project.

Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Abstract: A die apparatus for forging a steering rack from a bar. The die apparatus comprises a first and a second bolster movable towards each other, and at least one gripper adapted to grip the bar as the rack is forged. The gripper comprises first and second gripper halves carried by, and movable relative to, the first and second bolsters respectively. A gripper bias means biases the gripper halves towards each other. As the bolsters move towards each other to forge the rack, the first gripper half abuts against the first bolster, and the second gripper half abuts the second bolster.

Abstract: A system and method of navigating modeling of a building, including: receiving nonparametric user input building design data, organizing the nonparametric user input building design data, and globally editing the non-parametric data element in multiple objects within a building design.

Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Abstract: A system and method of analysis, including, but not limited to: receiving raw data related to at least one project; receiving user preferences in at least one workflow, wherein each step in the a workflow constitutes a single instance of a component of a workflow such that the state of a unique component is always the same if the same component is comprised in other workflows; determining metrics related to the at least one project; analyzing the data & metrics to identify patterns; drawing conclusions from the data, metrics and patterns; and generating at least one report that presents the metrics, patterns and conclusions.

Abstract: The present invention relates to a method for the generation of a Sitemap XML file. The method comprises retrieving input parameter values and determining at least one target entity (an online retail store) within a target environment (a retailer) for which a search engine sitemap definition page will be generated and rendering the sitemap definition page for the determined target entity. The rendered content being further evaluated and ordered according to predetermined priority algorithms. The method further comprises outputting the rendered sitemap definition page, where if the output sitemap definition page exceeds a predetermined size, the output sitemap definition page is divided into smaller segments and an index file is generated and associated with the segmented output sitemap definition page files. Caching functionality (to enhance operational performance) and access control functionality (for controlling the rendering of sitemaps) is further provided within aspects of the present invention.

Abstract: A die apparatus and method for performing a flashless forging operation to manufacture the toothed portion of a steering rack. The die apparatus includes first and second die members and at least one punch member, each having a forming surface shaped substantially as an obverse of a portion of the toothed portion. At least a portion of the forming surface of the first die member is shaped substantially as the obverse of the teeth of the rack. The first and second die members are moveable towards each other to a closed position, thereby partially forging the toothed portion from a blank placed in the die apparatus, and forming a substantially closed cavity defined by the forming surfaces. The punch member is adapted to move into the cavity once the die members are in the closed position, thereby completing the forging operation.

Abstract: There is disclosed a method and system for generating documentation for a graphical user interface (GUI) usage scenario. There is also disclosed a method and system for assembling a GUI script from a plurality of pre-scripted parts. In an embodiment, shadow objects are created to listen to and report activities of each GUI object of interest during a GUI usage session. The shadow objects may listen to shadowed GUI object activities during playback of the GUI script, or during a live GUI usage session. GUI object activities reported by the shadow objects are identified and converted into narrative language statements, using a pre-determined conversion list, to create human-readable documentation.

Abstract: A die apparatus and method for performing a flashless forging operation to manufacture the toothed portion of a steering rack. The die apparatus includes first and second die members and at least one punch member, each having a forming surface shaped substantially as an obverse of a portion of the toothed portion. At least a portion of the forming surface of the first die member is shaped substantially as the obverse of the teeth of the rack. The first and second die members are moveable towards each other to a closed position, thereby partially forging the toothed portion from a blank placed in the die apparatus, and forming a substantially closed cavity defined by the forming surfaces. The punch member is adapted to move into the cavity once the die members are in the closed position, thereby completing the forging operation.

Abstract: A system and method of analysis, including, but not limited to: receiving raw data related to at least one project; receiving user preferences in at least one workflow, wherein each step in the a workflow constitutes a single instance of a component of a workflow such that the state of a unique component is always the same if the same component is comprised in other workflows; determining metrics related to the at least one project; analyzing the data & metrics to identify patterns; drawing conclusions from the data, metrics and patterns; and generating at least one report that presents the metrics, patterns and conclusions.

Abstract: A die apparatus and method for performing a flashless forging operation to manufacture the toothed portion of a steering rack. The die apparatus includes first and second die members and at least one punch member, each having a forming surface shaped substantially as the obverse of a portion of the toothed portion. At least a portion of the forming surface of the first die member is shaped substantially as the obverse of the teeth of the rack. The first and second die members are moveable towards each other to a closed position, thereby partially forging the toothed portion from a blank placed in the die apparatus, and forming a substantially closed cavity defined by the forming surfaces. The punch member is adapted to move into the cavity once the die members are in the closed position, thereby completing the forging operation.

Abstract: A system and method for determining at least one climate energy index, comprising: at least one server and/or at least one client coupled to at least one application, the at least one application capable of: identifying at least one geographic location; identifying at least one human comfort zone; performing at least one energy calculation for weather ordinates associated with the at least one geographic location and the at least one human comfort zone; summing the at least one energy calculation for at least one time period; combining all the energy calculations to produce at least one energy total for the at least one geographic location; and determining at least one first index value associated with delivered energy based on the at least one energy total for the at least one geographic location.

Abstract: A heat exchanger device having a plurality of substantially parallel tubes. Each tube has an outer diameter which is less than or equal to one millimeter and further includes a first end portion and a second end portion. A first manifold forms an inlet for the first fluid and further forms a plurality of first openings, whereby each of the first end portions of the parallel tubes is attached in a sealed manner to the first manifold so that each tube is in fluid communication with a respective one of the first openings. A second manifold spaced from and opposing the first manifold forms an outlet for the first fluid and further forms a plurality of second openings, whereby each of the second end portions of the parallel tubes is attached in a sealed manner to the second manifold so that each tube is in fluid communication with a respective one of the second openings.

Abstract: A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.

Abstract: A system and method of analysis, including, but not limited to: receiving raw data related to at least one project; receiving user preferences in at least one workflow, wherein each step in the a workflow constitutes a single instance of a component of a workflow such that the state of a unique component is always the same if the same component is comprised in other workflows; determining metrics related to the at least one project; analyzing the data & metrics to identify patterns; drawing conclusions from the data, metrics and patterns; and generating at least one report that presents the metrics, patterns and conclusions.