Patents by Inventor John McMichael

John McMichael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5877198
    Abstract: The present invention relates to a treatment for patients having urinary incontinence by administering a composition comprising histamine, serotonin or a combination thereof in an amount effective to alleviate symptoms of urinary incontinence.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: March 2, 1999
    Assignee: Milkhaus Laboratory, Inc.
    Inventor: John McMichael
  • Patent number: 5798102
    Abstract: The invention presents methods for the treatment of symptoms associated with cardiomyopathy comprising treatment with an effective amount of a composition comprising beta-amyloid, streptolysin O, and growth hormone.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: August 25, 1998
    Assignee: Milkhaus Laboratory, Inc.
    Inventors: John McMichael, Harry C. Gurney
  • Patent number: 5753624
    Abstract: Methods and compositions are provided for alleviation of disease states involving plaque formation, such as are manifested in Alzheimer's Disease and other amyloid disorders, and arteriosclerotic disease. Methods for the treatment of herpes virus infections by administration of thimerosal are further provided by the invention.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: May 19, 1998
    Assignee: Milkhaus Laboratory, Inc.
    Inventors: John McMichael, Ellis L. Kline
  • Patent number: 5736508
    Abstract: Methods are presented for treatment in eliminating or reducing the appearance of scar tissue by administration of streptolysin O.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: April 7, 1998
    Assignee: Milkhaus Laboratory, Inc.
    Inventor: John McMichael
  • Patent number: 5726160
    Abstract: Methods for treating respiratory disease, including cystic fibrosis, emphysema, bronchitis, and sinusitis are presented. Methods comprise administering to a patient an effective amount of DNA in a manner so as not to effect gene transfer and expression.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: March 10, 1998
    Assignee: Milkhaus Laboratories, Inc.
    Inventor: John McMichael
  • Patent number: 5610136
    Abstract: The present invention is directed to methods of treating benign prostatic hypertrophy comprising the step of administering to a subject suffering from benign prostatic hypertrophy a chorionic gonadotropin or a pharmaceutically active fragment or derivative thereof in an amount effective to alleviate one or more symptoms of benign prostatic hypertrophy.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: March 11, 1997
    Assignee: Milkhaus Laboratory, Inc.
    Inventor: John McMichael
  • Patent number: 5576289
    Abstract: Methods are presented for treatment of motor deficit symptoms in patients who have a disease, such as multiple sclerosis, characterized by the presence of motor deficit symptoms.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: November 19, 1996
    Assignee: Milkhaus Laboratory
    Inventor: John McMichael
  • Patent number: 4970071
    Abstract: A method and composition for treating malignant neoplasia and acquired immune deficiency syndrome by once daily administration of a substance (such as human chorionic gonadotropin) characteristic of the tumor or acquired immune deficiency syndrome-afflicted cell in an amount less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: November 13, 1990
    Inventor: John McMichael
  • Patent number: 4966753
    Abstract: A method and composition for treating malignant neoplasia and acquired immune deficiency syndrome by once daily administration of a substance (such as human chorionic gonadotropin) characteristic of the tumor or acquired immune deficiency syndrome-afflicted cell in an amount less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: October 30, 1990
    Assignee: Molecular Rx, Inc.
    Inventor: John McMichael
  • Patent number: 4880626
    Abstract: Methods and compositions useful for treating acquired immune deficiency syndrome by once daily administration of substances characteristic of acquired immune deficiency syndrome-afflicted cell (such as human chorionic gonadotropin), and effective fragments and derivatives thereof, in a pharmaceutically effective amount less that the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration. Illustrative of such methods and compositions is the administration of a composition including human chorionic gonadotropin (HCG), a lysate of Staphylococcus aureus, influenza virus vaccine, and fractionated HIV virus, including peptide T.
    Type: Grant
    Filed: August 17, 1987
    Date of Patent: November 14, 1989
    Inventor: John McMichael
  • Patent number: 4877610
    Abstract: A method and composition for treating malignant neoplasia and acquired immune deficiency syndrome by once daily administration of a substance (such as human chorionic gonadotropin) characteristic of the tumor or acquired immune deficiency syndrome-afflicted cell in an amount less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration.
    Type: Grant
    Filed: August 18, 1987
    Date of Patent: October 31, 1989
    Inventor: John McMichael
  • Patent number: 4705685
    Abstract: In animals including humans, the symptoms of non-anaphylactic disease states wherein the disease victim's humoral and/or cell-mediated immunological response is involved in disease pathology are alleviated upon administration of compositions comprising mixtures of histamine and one or more immunogenic substances participative in the humoral or cell-mediated pathogenic response. In preferred embodiments, the compositions are administered in essentially minute, "neutralizing" doses. Illustratively, significant relief of symptoms of multiple sclerosis is achieved through parenteral (e.g., subcutaneous or sublingual) administration of mixtures of histamine and measles virus immunogen. For a majority of patients, from about 8.8.times.10.sup.-6 to 5.5.times.10.sup.-3 mg of histamine phosphate will provide an effective quantity of histamine to a unit dose of the mixture. Likewise, a unit does of the mixture will contain from about 2.times.10.sup.-3 to about 4.times.10.sup.
    Type: Grant
    Filed: March 5, 1985
    Date of Patent: November 10, 1987
    Inventor: John McMichael
  • Patent number: 4704273
    Abstract: Disclosed are methods and compositions useful for alleviating the symptoms of rheumatoid arthritis. In preferred embodiments, the compositions are administered in essentially minute "neutralizing" doses. The compositions comprise mixtures of histamine, immunoglobulin G provocative of RF formation or an immunologically active fraction thereof, collagen and either attenuated measles virus or immunologically active fraction thereof. Illustratively significant relief of symptoms of arthritis disease symptoms is achieved through parenteral (e.g., subcutaneous or sublingual) administration of such compositions.
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: November 3, 1987
    Inventor: John McMichael
  • Patent number: 4692332
    Abstract: A method and composition for treating malignant neoplasia and acquired immune deficiency syndrome by once daily administration of a substance (such as human chorionic gonadotropin) characteristic of the tumor or acquired immune deficiency syndrome-afflicted cell in an amount less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration.
    Type: Grant
    Filed: January 18, 1985
    Date of Patent: September 8, 1987
    Inventor: John McMichael
  • Patent number: 4689222
    Abstract: A method and composition useful for the alleviation of pain symptoms associated with malignant neoplasia and acquired immune deficiency syndrome by once daily administration of a substance (such as human chorionic gonadotropin) characteristic of the tumor or acquired immune deficiency syndrome-afflicted cell in an amount less that the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration.
    Type: Grant
    Filed: December 9, 1985
    Date of Patent: August 25, 1987
    Inventor: John McMichael
  • Patent number: 4521405
    Abstract: In animals including humans, the symptoms of non-anaphylactic disease states wherein the disease victim's humoral and/or cell-mediated immunological response is involved in disease pathology are alleviated upon administration of compositions comprising mixtures of histamine and one or more immunogenic substances participative in the humoral or cell-mediated pathogenic response. In preferred embodiments, the compositions are administered in essentially minute, "neutralizing" doses. Illustratively, significant relief of symptoms of multiple sclerosis is achieved through parenteral (e.g., subcutaneous of sublingual) administration of mixtures of histamine and measles virus immunogen. For a majority of patients, from about 8.8.times.10.sup.-6 to 5.5.times.10.sup.-3 mg of histamine phosphate will provide an effective quantity of histamine to a unit dose of the mixture. Likewise, a unit dose of the mixture will contain from about 2.times.10.sup.-3 to about 4.times.10.sup.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: June 4, 1985
    Assignee: John McMichael
    Inventor: John McMichael
  • Patent number: 4294818
    Abstract: Methods and materials for diagnosis of a multiple sclerosis disease state. Antigenic blood fractions from patients clinically diagnosed for multiple sclerosis are employed to generate heterologous species antibodies. Novel antibody preparations are employed to detect the presence or absence, in a blood sample of a patient to be tested, of immunologically significant components specifically associated with a multiple sclerosis disease state.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: October 13, 1981
    Assignee: University Patents, Inc.
    Inventors: John McMichael, Ellis L. Kline, James G. Spaulding