Abstract: A spray nozzle (10) includes a nozzle body (12) and a chemicalcontaining cartridge (28) releasably attached to the nozzle body (12). The cartridge (28) can be adapted to be releasably secured to the nozzle body (12) at the outlet end (16), the inlet end (14), or on the nozzle body (12) itself, in order to dispense a chemical contained within the cartridge into a water stream flowing through the nozzle. The nozzle (10) also includes a dispensing mechanism utilized to control the amount of the chemical dispensed into the water stream. The dispensing mechanism can be disposed on the nozzle body (12), or directly on the cartridge (28) itself.

Abstract: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type I diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues. The administration of the proteins of the invention in accordance with the immunomodulatory methods of the invention results in beneficial effects on disease development and severity in patients suffering from or predicted to be at risk of developing Type 1 diabetes, as well as on the outcome of transplants of pancreatic cells or tissues in Type I diabetes patients.

Abstract: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type I diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues.

Abstract: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type I diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues. The administration of the proteins of the invention in accordance with the immunomodulatory methods of the invention results in beneficial effects on disease development and severity in patients suffering from or predicted to be at risk of developing Type 1 diabetes, as well as on the outcome of transplants of pancreatic cells or tissues in Type I diabetes patients.

Abstract: A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.

Abstract: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type 1 diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues. The administration of the proteins of the invention in accordance with the immunomodulatory methods of the invention results in beneficial effects on disease development and severity in patients suffering from or predicted to be at risk of developing Type 1 diabetes, as well as on the outcome of transplants of pancreatic cells or tissues in Type 1 diabetes patients.

Abstract: An X-ray localizer light system comprises: a long life X-ray localizer light source; an optical concentrator, the light source being situated at a first focal spot, the optical concentrator being configured for concentrating X-ray localizer light from the light source to a second focal spot; and an opaque shield having an aperture therein situated proximate to the second focal spot and being of such a geometrical shape so as to maximize light throughput while meeting light field edge contrast requirements. In another light system, the optical concentrator comprises a reflector comprising a quasi-ellipsoidal portion within which the light source is situated, a cylindrical portion situated between the quasi-ellipsoidal portion and the shield for reflecting stray light, a back reflector portion situated proximate to the shield, and a centrally-mounted portion situated between the aperture and the light source for directing back-reflected light in the direction of the aperture.

Abstract: An infusion system includes an infusion device and a sensing device. The infusion system may further include a characteristic determining device. The infusion device also includes a communication system for transmitting to and receiving communications from the sensing device or a computer. The sensing device may sense an analyte of a bodily fluid of the user. The analyte may be calibrated using data from the infusion device and from a characteristic determining device. The system may be set up to automatically call for assistance when analytes reach a certain level.

Abstract: Apparatuses and methods for medical monitoring physiological characteristic values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide for preventing any negative consequence in the operation of a monitor and/or infusion device as a result of disorientation that may occur from waking from slumber with a low blood glucose level. In addition, a graphical display is disclosed incorporating a variety of enhancements which readily conveys to the user historical as well as real time information regarding the measured characteristic value.

Abstract: An X-ray localizer light system comprises: a long life X-ray localizer light source; an optical concentrator, the light source being situated at a first focal spot, the optical concentrator being configured for concentrating X-ray localizer light from the light source to a second focal spot; and an opaque shield having an aperture therein situated proximate to the second focal spot and being of such a geometrical shape so as to maximize light throughput while meeting light field edge contrast requirements. In another light system, the optical concentrator comprises a reflector comprising a quasi-ellipsoidal portion within which the light source is situated, a cylindrical portion situated between the quasi-ellipsoidal portion and the shield for reflecting stray light, a back reflector portion situated proximate to the shield, and a centrally-mounted portion situated between the aperture and the light source for directing back-reflected light in the direction of the aperture.

Abstract: An X-ray localizer light system comprises: a long life X-ray localizer light source; an optical concentrator, the light source being situated at a first focal spot, the optical concentrator being configured for concentrating X-ray localizer light from the light source to a second focal spot; and an opaque shield having an aperture therein situated proximate to the second focal spot and being of such a geometrical shape so as to maximize light throughput while meeting light field edge contrast requirements. In another light system, the optical concentrator comprises a reflector comprising a quasi-ellipsoidal portion within which the light source is situated, a cylindrical portion situated between the quasi-ellipsoidal portion and the shield for reflecting stray light, a back reflector portion situated proximate to the shield, and a centrally-mounted portion situated between the aperture and the light source for directing back-reflected light in the direction of the aperture.

Abstract: An LED light device comprising an LED for generating a light beam, and a reflector that concentrates the light beam to have bright illumination, uniform light field, and sharp edge contrast. The LED light device may be used in an x-ray collimator to facilitate positioning a patient and an x-ray machine relative to each other so that an x-ray beam is directed along a defined axis and onto a specified target zone on the patient. The collimator comprises at least one high energy LED array for generating a light beam and directing the light beam along the defined axis, wherein the light beam expands outward from the LED array at a beam cone angle, and an optical concentrator having a reflective surface, wherein the light beam is emitted from the LED array at a beam cone angle defined by the reflective surface of the optical concentrator.

Abstract: The present invention provides apparatus and methods for loading delivery systems, such as seed magazines and suture material, with seeds which greatly increases productivity, reduces process variation and reduces the risk of handling damage to the seeds. Importantly, the apparatus and methods of the present invention reduce potential risks to workers. In a first aspect of the invention there is provided an automated method of loading a delivery system for brachytherapy seeds which comprises the steps of a) securing the delivery system to be loaded; b) conmnunicating seeds from a supply of seeds into the delivery system; and c) repeating step b) to load a plurality of seeds. In a second aspect of the invention there is provided an apparatus for loading a delivery system for brachytherapy seeds comprising: a) means for retaining a delivery system to be loaded with seeds; and b) means for communicating individual seeds from a supply of seeds to said delivery system.

Abstract: An X-ray localizer light system comprises: a long life X-ray localizer light source; an optical concentrator, the light source being situated at a first focal spot, the optical concentrator being configured for concentrating X-ray localizer light from the light source to a second focal spot; and an opaque shield having an aperture therein situated proximate to the second focal spot and being of such a geometrical shape so as to maximize light throughput while meeting light field edge contrast requirements. In another light system, the optical concentrator comprises a reflector comprising a quasi-ellipsoidal portion within which the light source is situated, a cylindrical portion situated between the quasi-ellipsoidal portion and the shield for reflecting stray light, a back reflector portion situated proximate to the shield, and a centrally-mounted portion situated between the aperture and the light source for directing back-reflected light in the direction of the aperture.

Abstract: The present invention provides peptide compounds which bind to the androgen receptor. In preferred embodiments, the peptide compounds of the invention inhibit binding of the androgen receptor DNA binding domain to DNA, in particular, the androgen responsive elements. These compounds are useful for the treatment of androgen-associated disorders including, for example, prostate cancer.

Abstract: A circuit for loading the rectified AC voltage bus in a housekeeping power supply for an electronically controlled load is provided for avoiding large increases in the rectified AC bus voltage upon disconnecting the load. The load circuit includes a current sink, a relatively small energy storage capacitance, and a negative feedback circuit. The current sink includes a resistance coupled to the rectified AC voltage bus for sinking current whenever the semiconductor switch is on. When the semiconductor switch is off, the small capacitance discharges through the resistive voltage divider. When the voltage across the small capacitance decreases to a threshold mean AC rectified voltage bus value, then the negative feedback circuit provides sufficient current to turn the semiconductor switch back on and thus provide approximately the threshold mean AC rectified voltage bus value.

Abstract: A machine automatically closes flip-top caps and tests their covers for proper opening and closing force. The machine has a pair of superimposed turntables separated by a wheel, the turntables and wheel turning as a unit about a common axis. The wheel has a plurality or pockets distributed around the periphery thereof to receive the open flip-flop caps after they are molded. The pockets are adjustable in size to accommodate caps of different diameters and heights. Cap gripping assemblies associated with each pocket firmly grip the cap to resist integral and vertical displacement of the cap. At least one and, in a preferred embodiment, both of the turntables have actuators positioned near each pocket on the wheel. Cams surround the turntables to raise and lower the actuators at selected locations. As the actuators raise and lower, the covers are flipped over to close the caps. Selected forces are applied through the actuators and corresponding cap opening fingers to reopen and reclose the covers.