Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: An automated dental drill includes a dental drill housing that includes a mouth piece housing section and a one or more degrees of freedom drive housing section; an end effector drive support having a shaft section that is at least partially positioned in the mouth piece housing section, and an end effector for the cutting of a native tooth or dental appliance to a desired tolerance. The end effector is positioned on the end effector drive support. The automated dental drill also includes a power source that drives the end effector and is coupled to the end effector and a one or more degrees of freedom drive assembly to direct the end effector along one or more degrees of freedom relative to the mouth piece housing section.

Abstract: Provided herein are tooth clamping systems, methods, and kits for performing a dental procedure with a dental cutting machine guided by three-dimensional data associated with an impression of one or more teeth of a patient.

Abstract: Ingestible devices capable of delivering a dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are disclosed. A removably attachable storage reservoir configured to be used with an ingestible device and capable of storing dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are also disclosed.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A method for recycling powdered paint waste is provided in which, the powdered paint waste is being treated with the aid of a reactant in such a way that its adhesion to surfaces and especially to metal surfaces is reduced or eliminated. The treatment of the powdered paint waste allows the powdered paint waste to be additionally processed under the influence of heat and to use it as a starting material in various recycling processes or in other processes.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: Provided herein are platforms and methods for mapping a three-dimensional (3D) dental anatomy of a subject.

Abstract: A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: Disclosed herein are apparatuses and methods for 3D data generation for tooth prosthetic crown preparation.

Abstract: A method for rendering material surfaces inert is provided. Exemplary surfaces include ceramic, metal or plastic surfaces. The method is accomplished with functionalized perfluorinated compounds for the formation of hyperhydrophobic structures on the surfaces to create inert surfaces. The inert surfaces produced or can be produced in this way have an extremely low surface energy, are resistant to deposits of substances or cells and have a very low coefficient of friction. Practical uses of the inert surfaces are also provided.

Abstract: Methods and systems for a catheter access port cleaning, disinfection or sterilization device are disclosed. The catheter access port cleaning, disinfection or sterilization device may comprise, a first housing having a power source and control circuit; a second housing shaped to mate with a catheter and having a first ultra-violet light source mounted therein, the first housing wired to the second housing to power the light source. When activated, the ultra-violet light source emits ultra-violet radiation that is transmitted from the second housing to the catheter attached to a patient. In this way, the device provides an efficient system for cleaning, disinfecting or sterilizing an access port in the second housing while reducing patient infections.

Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

Abstract: An automated dental drill includes a dental drill housing that includes a mouthpiece housing section and a one or more degrees of freedom drive housing section; an end effector drive support having a shaft section that is at least partially positioned in the mouth piece housing section, and an end effector for the cutting of a native tooth or dental appliance to a desired tolerance. The end effector is positioned on the end effector drive support. The automated dental drill also includes a power source that drives the end effector and is coupled to the end effector and a one or more degrees of freedom drive assembly to direct the end effector along one or more degrees of freedom relative to the mouth piece housing section.

Abstract: An apparatus and method for automated dental treatment having a tooth clamp (48, 700) which connects an automated dental drill (10). The tooth clamp (700) has a rigid frame (704A, 704B) with a coupling point (703) for reversibly coupling the tooth clamp (700) to an automated dental drill (10) and a pair of jaws (701A, 701B) for coupling the clamp to a tooth of a user. A first jaw surface has a shape adapted to mate the tooth surface and is fabricated based on surface data or a three-dimensional model of the scanned tooth. The tooth clamp (700) has suction ports (702) and the system (900) has irrigation nozzles (903).

Abstract: Systems and methods have been developed for implementation of a breath testing system for convenient sampling of intestinal gases exhaled from a patient's breath. This may include a system with a manifold that includes thermal regulation components, for instance thermistors and resistive heating elements, which maintain the temperature of the gases above the body temperature of the patient. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.