Abstract: A system may include one or more computing devices configured to receive image data representing illuminated powder of a powder stream between a powder delivery device of an additive manufacturing system and a build surface of a component; determine at least one metric associated with the powder stream based on the received image data; determine whether the at least one metric indicates an abnormal state of the at least one metric; and cause the additive manufacturing system to perform at least one action in response to determining that the at least one metric indicates the abnormal state.

Abstract: A powder flow monitoring system may include a computing device configured to receive image data representing illuminated powder of a powder stream between a powder delivery device and a build surface of a component, generate a representation of the powder stream based on the image data, and output the representation of the powder stream for display at a display device.

Abstract: An additive manufacturing system may include a powder delivery device configured to direct a powder stream toward a build surface of a component, and a powder flow monitoring system. The powder delivery device defines a longitudinal axis oriented toward the build surface. The powder flow monitoring system includes an illumination device configured to illuminate at least some powder the powder stream between the powder delivery device and the build surface; and an imaging device configured to image the illuminated powder at an image plane that intersects the longitudinal axis. The illumination device and the imaging device may be registered to the powder delivery device in a plane substantially orthogonal to the longitudinal axis.

Abstract: A device and a method for creating and/or maintaining an obstruction free upper airway. The device fits under the chin of a subject adjacent to the subject's neck at an external location corresponding approximately with the subject's internal soft tissue associated with the neck's anterior triangle. The device is capable of exerting negative pressure on the surface of a subject's neck, displacing the soft tissue forward and enlarging the airway.

Abstract: A method for processing network data, comprising receiving a data packet at a first processor having a non-transient data memory, storing the data packet in the non-transient data memory, accessing one or more first data fields of the data packet in the data memory, determining whether a device is bandwidth limited as a function of the first data fields being associated with an application, transmitting the data packet to a second processor over a network if it is determined that the device is not bandwidth limited, determining whether the device has reached a limit if it is determined that the device is bandwidth limited, transmitting the data packet to the second processor over the network if it is determined that the limit has not been reached and deleting the data packet without transmitting the data packet if it is determined that the limit has been reached.

Abstract: The present invention provides a method of providing a disposable product with zero waste ear formation and attaching the ears to a running chassis web.

Abstract: A robot end effector (100) for dispensing an extrudable substance (102) comprises cartridge bays (122). Each one of the cartridge bays (122) is shaped to receive one of two-part cartridges (104). Each of the two-part cartridges (104) comprises a cartridge outlet (109). The robot end effector (100) also comprises a head assembly (150), comprising pairs of fittings (152). Each pair of the pairs of fittings (152) is configured to selectively supply compressed air from a pressure source (199) to contents of one of the two-part cartridges (104) when the two-part cartridges (104) are received by the cartridge bays (122) and the cartridge bays (122) are translated along a first axis (190) and along a second axis (192) so that the cartridge outlet (109) of the corresponding one of the two-part cartridges (104) is in fluidic communication with the mixer inlet (103).

Abstract: A robot end effector (100) for dispensing an extrudable substance (102) comprises a chassis (110), a static mixer (101), and cartridge bays (122), extending from the chassis (110). Each of the cartridge bays (122) is shaped to receive a corresponding one of the two-part cartridges (104). Fluidic communication between the selected one of the two-part cartridges (104) and the static mixer (101) is established when the cartridge bays (122) are rotated about an axis (190) to a predetermined orientation with respect to the chassis (110). The robot end effector (100) also comprises a dispensing valve (130), attached to the chassis (110), and a head assembly (150), comprising an inlet manifold (152). The inlet manifold (152) is configured to selectively supply compressed air from a pressure source (199) to contents of a corresponding one of the two-part cartridges (104).

Abstract: Systems and methods are disclosed for estimating slipperiness of a road surface. This estimate may be obtained using an image sensor mounted on a vehicle. The estimated road slipperiness may be utilized when calculating a risk index for the road, or for an area including the road. If a predetermined threshold for slipperiness is exceeded, corrective actions may be taken. For instance, warnings may be generated to human drivers that are in control of driving vehicle, and autonomous vehicles may automatically adjust vehicle speed based upon road slipperiness detected.

Abstract: Transdermal drug delivery devices are described herein such as a microneedle array patch, to be placed on the skin for transdermal delivery of a medicament. The transdermal drug delivery device for delivery of a bioactive agent through mammalian skin comprises an array of microneedles and a means to actuate the microneedles, wherein the actuation means actuates the microneedles separately.

Abstract: An implantable device for penile construction can comprise an anchor plate and at least one attachment member. The anchor plate can be configured to engage with a first portion of a pelvic bone of a patient. The anchor plate can comprise a prosthesis attachment interface configured to be coupled to a penile prosthesis, and at least one attachment member configured to attach to the anchor plate. The at least one attachment member can be configured to engage with a second portion of the pelvic bone of the patient. The engagement of the anchor plate with the first portion of the pelvic bone and the engagement of the attachment member with the second portion of the pelvic bone can couple the pelvic bone between the anchor plate and the at least one attachment member.

Abstract: A system that is mountable to an unmanned vehicle and a method of operation is provided. The system includes an attachment plate configured to couple to the unmanned vehicle, the attachment plate having a first feature. A control module is configured to removably couple to the attachment plate, the control module having one or more processors and a power source, the control module having a pin arranged to move from a first position to a second position when the control module is coupled to the attachment plate, the one or more processors being energized when the pin is moved from the first position to the second position. A payload having an energetic element is provided, the payload being coupled to the control module.

Abstract: The novel tissue products of the present invention are generally produced by calendering a tissue basesheet using at least one patterned roll. In one embodiment the patterned roll replaces the flat steel roll commonly used in calendering. The elements on the patterned roll provide a means of providing a nip having variable loading that yields a web having a smooth surface without subjecting the web to excessive compression forces and preventing excessive caliper loss. Thus, webs converted according to the present invention have comparable or better surface smoothness compared to webs converted using conventional calendering means and also retain a greater percentage of their caliper and bulk.

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

Abstract: In a ray tracer, to prevent any long-running query from hanging the graphics processing unit, a traversal coprocessor provides a preemption mechanism that will allow rays to stop processing or time out early. The example non-limiting implementations described herein provide such a preemption mechanism, including a forward progress guarantee, and additional programmable timeout options that can be time or cycle based. Those programmable options provide a means for quality of service timing guarantees for applications such as virtual reality (VR) that have strict timing requirements.

Abstract: Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

Abstract: A grabber assembly including a carriage, a pin, a first adapter, a second adapter, and a sleeve. The pin extends through a bushing of a grabber arm. The bushing is pivotally coupled with the pin. The first adapter is coupled with the carriage and configured to receive a first end of the pin. The second adapter is coupled with the carriage and configured to receive a second end of the pin. The sleeve extends co-cylindrically with the pin, the sleeve positioned within a central bore of the bushing between the bushing and the pin.

Abstract: Systems and methods are disclosed for estimating slipperiness of a road surface. This estimate may be obtained using an image sensor mounted on a vehicle. The estimated road slipperiness may be utilized when calculating a risk index for the road, or for an area including the road. If a predetermined threshold for slipperiness is exceeded, corrective actions may be taken. For instance, warnings may be generated to human drivers that are in control of driving vehicle, and autonomous vehicles may automatically adjust vehicle speed based upon road slipperiness detected.

Abstract: A microfluidic device for use in a serial crystallography apparatus includes a modular 3D-printed nozzle having an inlet, an outlet, and a first snap engagement feature. The microfluidic device further includes a modular 3D-printed fiber holder having an outlet and a second snap engagement feature. The first snap engagement feature is configured to engage the second snap engagement feature to removably couple the nozzle to the fiber holder. The outlet of the fiber holder is aligned with the inlet of the nozzle when the first snap engagement feature is coupled to the second snap engagement feature.

Abstract: A device and a method for creating and/or maintaining an obstruction free upper respiratory passages. The device is configured to fit under the chin of a subject adjacent to the subject's neck at an external location corresponding approximately with the subject's soft tissue associated with the neck's anterior triangle. The device is capable of exerting negative pressure on the surface of a subject's neck, displacing the soft tissue forward and enlarging the airway.