Abstract: This disclosure describes a modular hydraulic manifold for controlling an operation of a hydraulic actuator for an earthmoving machine. The manifold has a spool chamber and a load sensing passageway. The body also has a spool positioned axially within the spool chamber. The spool is spring-biased by an end cap. The module also has a pair of spool actuators that are located at a second end of the body and operable to axially displace the spool within the spool chamber. The pair of spool actuators are positioned in parallel and disposed adjacent to one another. The manifold also has an inlet chamber disposed parallel to the spool chamber and in selective fluid communication with the spool chamber via a spool supply passageway. The body includes openings on opposite sides that open directly to inlet and spool chambers of adjacent bodies to reduce passageway constriction within the hydraulic system.

Abstract: This disclosure describes a modular hydraulic manifold for controlling an operation of a hydraulic actuator for an earthmoving machine. The manifold has a spool chamber and a load sensing passageway. The body also has a spool positioned axially within the spool chamber. The spool is spring-biased by an end cap. The module also has a pair of spool actuators that are located at a second end of the body and operable to axially displace the spool within the spool chamber. The pair of spool actuators are positioned in parallel and disposed adjacent to one another. The manifold also has an inlet chamber disposed parallel to the spool chamber and in selective fluid communication with the spool chamber via a spool supply passageway. The body includes openings on opposite sides that open directly to inlet and spool chambers of adjacent bodies to reduce passageway constriction within the hydraulic system.

Abstract: An emergency medical treatment system is provided that can be used in connection with providing prehospital medical treatment to a patient. The system includes a patient data display device programmed to receive and display data associated with the patient; an environmental assessment device configured to capture visual, aural, or other ambient environmental data associated with an emergency treatment site associated with the patient; a patient monitoring device configured to be positioned on the patient and having multiple sensors programmed to collect physiological data or vitals data associated with the patient; and a patient data processing device configured with a speech-to-text module. Rules-based or machine learning based algorithm modules can be provided for generating alerts or making treatment option recommendations in connection with the patient data collected and displayed on the patient display device.

Abstract: Methods, apparatus, and processor-readable storage media related to a robotic system for automated soil testing and analyses are provided herein. A computer-implemented method includes processing data pertaining to a given geographical region, generating one or more navigational courses within the given geographical region based at least in part on the processed data, and automatically collecting one or more soil samples at one or more predetermined locations within the given geographical region, in accordance with at least one of the generated navigational courses. Such a method also includes automatically analyzing the one or more collected soil samples based on one or more predetermined soil-related parameters, and generating and outputting results of the analyzing of the one or more collected soil samples.

Abstract: An emergency medical treatment system is provided that can be used in connection with providing prehospital medical treatment to a patient. The system includes a patient data display device programmed to receive and display data associated with the patient; an environmental assessment device configured to capture visual, aural, or other ambient environmental data associated with an emergency treatment site associated with the patient; a patient monitoring device configured to be positioned on the patient and having multiple sensors programmed to collect physiological data or vitals data associated with the patient; and a patient data processing device configured with a speech-to-text module. Rules-based or machine learning based algorithm modules can be provided for generating alerts or making treatment option recommendations in connection with the patient data collected and displayed on the patient display device.

Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

Abstract: A cell culture platform for modeling metastatic cancer is disclosed. The platform comprises one or more cell culture vessels comprising a plurality of compartments. Each compartment houses a substrate include a decellularized tissue-specific extracellular matrix derived from tissue of a different anatomical region. Each tissue-specific extracellular matrix comprises a homogenous mixture of macromolecule fragments including collagen, elastin, and glycosaminoglycan. A kit for culturing cells in biomimetic environments is also disclosed. The kit comprises a plurality of substrate precursors and at least one reagent. Each substrate precursor comprises a decellularized tissue-specific extracellular matrix derived from tissue of a different anatomical region. The tissue-specific extracellular matrix comprises a homogenous mixture of macromolecule fragments including collagen, elastin, and glycosaminoglycan.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An emergency medical treatment system is provided that can be used in connection with providing prehospital medical treatment to a patient. The system includes a patient data display device programmed to receive and display data associated with the patient; an environmental assessment device configured to capture visual, aural, or other ambient environmental data associated with an emergency treatment site associated with the patient; a patient monitoring device configured to be positioned on the patient and having multiple sensors programmed to collect physiological data or vitals data associated with the patient; and a patient data processing device configured with a speech-to-text module. Rules-based or machine learning based algorithm modules can be provided for generating alerts or making treatment option recommendations in connection with the patient data collected and displayed on the patient display device.

Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same as mTORC1 inhibitors.

Abstract: An emergency medical treatment system is provided that can be used in connection with providing prehospital medical treatment to a patient. The system includes a patient data display device programmed to receive and display data associated with the patient; an environmental assessment device configured to capture visual, aural, or other ambient environmental data associated with an emergency treatment site associated with the patient; a patient monitoring device configured to be positioned on the patient and having multiple sensors programmed to collect physiological data or vitals data associated with the patient; and a patient data processing device configured with a speech-to-text module. Rules-based or machine learning based algorithm modules can be provided for generating alerts or making treatment option recommendations in connection with the patient data collected and displayed on the patient display device.

Abstract: Systems and methods are provided for use in monitoring decentralized data structures including identity attributes, through tokenization of the attributes. One example computer-implemented method includes receiving a request associated with a digital identity including multiple attributes and, for each of the attributes in the request, generating a token specific to the attribute, searching for the generated token in a network graph having multiple stored tokens, and identifying one of the multiple stored tokens as a match to the generated token. The computer-implemented method then further includes, for each of the attributes in the request, retrieving additional ones of the multiple stored tokens linked to the identified one of the stored tokens, comparing the retrieved tokens to the generated token, and promoting the request for further action, in response to at least one of the retrieved tokens being inconsistent with the generated token.

Abstract: The present invention relates to a computer-vision based autonomous steerable catheter device and methods of using the same for targeted delivery of a liquid microvolume into the interior of a lung.

Abstract: Bacillus strains, compositions and methods are disclosed for reducing growth of microorganisms in a feed. Bacillus strains, compositions and methods are disclosed for providing beneficial effects to animals, including but not limited to increasing performance of the animal.

Abstract: Systems and methods are provided for generating audit log entries for data packet transactions. One example computer-implemented method includes, in response to a request to share data about a user with a first party, retrieving data identified in the request and generating a transaction ID for the request where the transaction ID is unique to the request to share the data. The method also includes compiling a data packet including at least the transaction ID and the identified data, and generating a signature value for the data packet. The method then further includes transmitting, by the computing device, the data packet to the first party as a transaction and appending an entry to an audit log, which includes the transaction ID and the signature value, but not the identified data.

Abstract: The present invention relates to a compound of formula (I) for use in the treatment or prevention of an autoinflammatory disorder such as cryopyrin-associated periodic syndrome (CAPS), tumor necrosis factor receptor associated periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), familial mediterranean fever (FMF), Behcet Disease, Pyoderma Gangraenosum, systemic onset of juvenile idiopathic arthritis (sJIA), Schnitzler syndrome, or Hidradenitis Suppurativa.