Abstract: An urethral antimicrobial delivery device (1) comprising; a deformable reservoir (101) in fluid connection with an elongate member (102), the elongate member comprising a lumen, the elongate member having a proximal end and a distal end, the elongate member having a plurality of pores (103) defined therein, said pores being distributed along a length of said elongate member, the elongate member being dimensioned for insertion through an external urethral orifice of a female subject, whereby the elongate member is insertable into a distal urethral cavity for delivery of at: antimicrobial in said distal urethral cavity, and wherein the device comprises a collar (105) to prevent said elongate member entering a proximal urethral cavity.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An emergency medical treatment system is provided that can be used in connection with providing prehospital medical treatment to a patient. The system includes a patient data display device programmed to receive and display data associated with the patient; an environmental assessment device configured to capture visual, aural, or other ambient environmental data associated with an emergency treatment site associated with the patient; a patient monitoring device configured to be positioned on the patient and having multiple sensors programmed to collect physiological data or vitals data associated with the patient; and a patient data processing device configured with a speech-to-text module. Rules-based or machine learning based algorithm modules can be provided for generating alerts or making treatment option recommendations in connection with the patient data collected and displayed on the patient display device.

Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same as mTORC1 inhibitors.

Abstract: An emergency medical treatment system is provided that can be used in connection with providing prehospital medical treatment to a patient. The system includes a patient data display device programmed to receive and display data associated with the patient; an environmental assessment device configured to capture visual, aural, or other ambient environmental data associated with an emergency treatment site associated with the patient; a patient monitoring device configured to be positioned on the patient and having multiple sensors programmed to collect physiological data or vitals data associated with the patient; and a patient data processing device configured with a speech-to-text module. Rules-based or machine learning based algorithm modules can be provided for generating alerts or making treatment option recommendations in connection with the patient data collected and displayed on the patient display device.

Abstract: Systems and methods are provided for use in monitoring decentralized data structures including identity attributes, through tokenization of the attributes. One example computer-implemented method includes receiving a request associated with a digital identity including multiple attributes and, for each of the attributes in the request, generating a token specific to the attribute, searching for the generated token in a network graph having multiple stored tokens, and identifying one of the multiple stored tokens as a match to the generated token. The computer-implemented method then further includes, for each of the attributes in the request, retrieving additional ones of the multiple stored tokens linked to the identified one of the stored tokens, comparing the retrieved tokens to the generated token, and promoting the request for further action, in response to at least one of the retrieved tokens being inconsistent with the generated token.

Abstract: The present invention relates to a computer-vision based autonomous steerable catheter device and methods of using the same for targeted delivery of a liquid microvolume into the interior of a lung.

Abstract: Bacillus strains, compositions and methods are disclosed for reducing growth of microorganisms in a feed. Bacillus strains, compositions and methods are disclosed for providing beneficial effects to animals, including but not limited to increasing performance of the animal.

Abstract: Systems and methods are provided for generating audit log entries for data packet transactions. One example computer-implemented method includes, in response to a request to share data about a user with a first party, retrieving data identified in the request and generating a transaction ID for the request where the transaction ID is unique to the request to share the data. The method also includes compiling a data packet including at least the transaction ID and the identified data, and generating a signature value for the data packet. The method then further includes transmitting, by the computing device, the data packet to the first party as a transaction and appending an entry to an audit log, which includes the transaction ID and the signature value, but not the identified data.

Abstract: The present invention relates to a compound of formula (I): for use in the treatment or prevention of neuroinflammation or an inflammatory brain disorder.

Abstract: The present invention relates to a compound of formula (I) for use in the treatment or prevention of an autoinflammatory disorder such as cryopyrin-associated periodic syndrome (CAPS), tumor necrosis factor receptor associated periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), familial mediterranean fever (FMF), Behcet Disease, Pyoderma Gangraenosum, systemic onset of juvenile idiopathic arthritis (sJIA), Schnitzler syndrome, or Hidradenitis Suppurativa.

Abstract: Techniques for improving data rates at mobile terminals that are subject to periodic channel interruptions in a beyond-line-of-sight communication system are disclosed, including improved encoding and decoding systems that identify blockages and modify receiver operation during blockages to reduce data errors. In certain embodiments, encoding, symbol mapping, interleaving, and use of unique periodic identifiers function to enable a series of packets that may be received in a blockage impaired channel with reduced errors.

Abstract: The present invention relates to a compound of formula (I): for use in the treatment or prevention of a neurodegenerative disorder.

Abstract: The present invention relates to a compound of formula (I) for use in the treatment or prevention of arthritis.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An in vitro cell culture substrate is disclosed. The substrate comprises a decellularized tissue-specific extracellular matrix, wherein the tissue-specific extracellular matrix is derived from fibrotic tissue. A method of method of assessing an in vitro fibrotic cell culture is also disclosed. The method comprises providing one or more substrates comprising decellularized tissue-specific extracellular matrix derived from fibrotic tissue, where each substrate is provided in segregated manner. The method further comprises culturing native cells in each substrate to form a fibrotic cell culture. The method further comprises assessing at least one characteristic of each fibrotic cell culture.