Abstract: An isolated polypeptide comprises an amino acid sequence of SEQ ID No. 1 or 2 or a variant or fragment thereof. The variant may comprise an amino acid sequence that is at least 70% or 95% identical to the amino acid sequence of SEQ ID No. 1 or 2. A fragment thereof may be a peptide comprising at least 12 contiguous amino acids of SEQ ID No. 1 or 2. The polypeptide exhibits toll-like receptor activity. The TLR has been named TLR1 4. TLR receptors recognise a range of ligands and activate a series of signalling pathways that lead to the induction of immune and inflammatory genes.

Abstract: Apparatus and methods for distributing print jobs. A print job is generated at an application node of a network, and has associated therewith print parameters. The print job is routed to a distribution node on the network. The parameters are then parsed from the generated print job and the print job parameterized with predetermined metrics that are a function of at least one of the parsed parameters. The parameterized print job is then routed to a destination device on a destination node on the network.

Abstract: The disclosure is directed to an interactive packaging system for monitoring the usage of personal hygiene products, personal hygiene product packages, and restroom facilities. The interactive packaging system may include a plurality of usage monitoring devices each configured to detect physical stimulus associated with the usage of the product, package or facility with which the usage monitoring device is associate, and to transmit usage messages containing information relating to the detected physical stimulus. The interactive packaging system may further include a base station configured to receive the usage messages transmitted by the plurality of usage monitoring devices and to generate sensory perceptible outputs corresponding to the information contained in the usage messages. Either the usage monitoring devices or the base station may be configured to determine whether the products, packages or facilities are used appropriately based on the detected physical stimulus.

Abstract: A flexible container including a flexible pouch having a dispensing aperture through which an interior space is accessible from outside the flexible pouch, a flexible sealing member releasably attached to the flexible pouch and covering the dispensing aperture, and a rigid closure element surrounding the dispensing aperture. The flexible sealing member has at least two lifting tabs for lifting the flexible sealing member and thereby exposing the dispensing aperture. The rigid closure element has a base permanently attached to the flexible pouch and lid connected to the base by a hinge. At least one of the lifting tabs is likely to not be obstructed by the rigid closure element when the lid is in an open condition, thereby remaining usable for lifting the flexible sealing member to expose the dispensing aperture, even if another lifting tab is obstructed by the rigid closure element.

Abstract: A cleaning wipe container includes a bottom panel, a front panel, a rear panel, a pair of side panels and a lid. The cleaning wipe container may be filled with a plurality of cleaning wipes that are contained in a cartridge. The container also includes a slidably engaged window that cooperatively interacts with the cartridge to display a message on or through a portion of a panel of the container. The message is based on the wipes in the cartridge and may include a type of wipe, a list of ingredients of the wipes, and/or instructions for using the wipes.

Abstract: A cleaning wipes container having one or more panels and a lid that covers an opening. The opening provides access to an interior storage space defined by the one or more panels. The interior storage space is configured to receive a wipes cartridge. The container also has a viewing area on at least a portion of one panel. The viewing area provides a target surface to join a transferable label. The transferable label includes indicia that relate to a characteristic of a type of cleaning wipes in the wipes cartridge. The indicia are viewable from outside the container.

Abstract: The present invention is directed to hydroxy-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

Abstract: The disclosure is directed to an interactive packaging system for monitoring the usage of personal hygiene products, personal hygiene product packages, and restroom facilities. The interactive packaging system may include a plurality of usage monitoring devices each configured to detect physical stimulus associated with the usage of the product, package or facility with which the usage monitoring device is associate, and to transmit usage messages containing information relating to the detected physical stimulus. The interactive packaging system may further include a base station configured to receive the usage messages transmitted by the plurality of usage monitoring devices and to generate sensory perceptible outputs corresponding to the information contained in the usage messages. Either the usage monitoring devices or the base station may be configured to determine whether the products, packages or facilities are used appropriately based on the detected physical stimulus.

Abstract: The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

Abstract: The present invention is directed to aminoalkyl-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

Abstract: A cleansing wipe container includes a bottom panel, a front panel, a rear panel, a pair of side panels and a lid. The cleansing wipe container may be filled with a plurality of cleansing wipes that are contained in a cartridge. The cartridge and container interact such that a message is displayed on or through a panel of the container. The message is based on the cartridge of wipes and may include a type of wipe, a list of ingredients of the wipes, and/or instructions for using the wipes.

Abstract: A hanger for mounting an object on a surface such as a wall. The hanger includes a slot that receives a projection such as a nail extending from the wall. The slot is nonlinear and provides an entry path through which the projection travels to reach its mounting position. The hanger also includes slot branches extending from the slot, which together with the slot create a maze through which the projection travels when the object is attempted to be removed from the wall. The slot branches provide dead end paths that the projection may encounter when the object is attempted to be removed from the wall.

Abstract: A fishing rod holder (10) is disclosed having a spool assembly (16), a web (18), and a handle assembly (20). The web may be substantially prevented from moving when holding fishing rods in place by a web locking means (46). The web locking means may prevent the spool from turning or a web pinch may be employed, among other embodiments.

Abstract: Apparatus and methods for distributing print jobs. A print job is generated at an application node of a network, and has associated therewith print parameters. The print job is routed to a distribution node on the network. The parameters are then parsed from the generated print job and the print job parameterized with predetermined metrics that are a function of at least one of the parsed parameters. The parameterized print job is then routed to a destination device on a destination node on the network.

Abstract: A brake assembly includes a mounting plate, pressure members disposed in a substantially coplanar manner relative to the mounting plate, and electric actuators mounted to the mounting plate. The electric actuators are configured to selectively move the pressure members relative to the mounting plate (i) from a non-braking position to a braking position in response to a first command, and (ii) from the braking position to the non-braking position in response to a second command. Such a brake assembly is well-suited for a variety of applications including vehicle brakes such as aircraft brakes.

Abstract: An information capture, processing and retrieval (“ICPR”) system shared by multiple buyers, suppliers and workers concurrently and a method of operating the same. In one embodiment, the ICPR system includes an order documentation subsystem configured to document orders for the suppliers and the buyers with respect to the workers. Each of the orders specifies a different method of time capture for the workers assigned thereto. The ICPR system also includes a time capture subsystem configured to receive the different methods of time capture from the workers positioned in one of anchored and untethered locations assigned to the orders. In a related embodiment, the ICPR system further includes a time approval and buyer tagging subsystem configured to allow the buyers to label time worked by the workers corresponding to the buyers with one or more tags, thereby translating approved time of the workers into custom, internal terminology of the buyers.

Abstract: A gaming apparatus for allowing players to explore decisions made in response to changing circumstances and to engage with the contradictions of competing needs. The gaming apparatus comprises a game board and game pieces. The board game is divided into an inner play area and an outer play area that surrounds the inner play area. An outer game piece traversing the outer play area determines functionality of one or more inner game pieces positioned on the inner play area. In each round of a game play, a player is either a Giver or a Taker, and moves inner game pieces according to their Point of View. Players' Points of View may exchange in every round. A player's goal is to be the Giver, since only the Giver can win. However, the Giver only wins when all four blue human being game pieces from a pyramid and meet Eye to Eye.

Abstract: In a satellite or other relayed communication system having a plurality of subscriber terminals that communicate through an elevated wireless relay (typically a satellite operating in bent pipe mode), a technique for subscriber terminal power control is provided whereby the power level is controlled via leader-follower operation relying on sharing control factors determined at a single calibrated subscriber terminal transmitter (the leader terminal) to create traffic to be compared to the received traffic of the other subscriber terminals. The power level of the subscriber terminals is then adjusted based on the relationship of their received energy to the received energy of the leader terminal.

Abstract: The present invention includes a method for the identification of novel compounds that interact and stabilize the ligand binding domain of ERR?, a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERR?.

Abstract: Method and apparatus for distributing print jobs. A print job is generated at an application node of a network, and has associated therewith print parameters. The print job is routed to a distribution node on the network. The parameters are then parsed from the generated print job and the print job parameterized with predetermined metrics that are a function of at least one of the parsed parameters. The parameterized print job is then routed to a destination device on a destination node the network.