Abstract: Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to a patient's brain for the treatment of mild traumatic brain injury (mTBI) and post-concussion symptoms. By stimulating the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in symptoms and pain may be achieved relative to earlier treatment techniques. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.

Abstract: Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Abstract: The technology relates generally to an interactive avatar training system. The interactive avatar training system utilizes an interactive platform that allows at least two users, such as a trainer and a trainee, to be in interactive communication in a training program. The interactive avatar training system may assist generating a processed answer or response from the trainer to the trainee so that the answer presented to the trainee has high level of accuracy. Thus, the training efficiency and accuracy may be enhanced and improved.

Abstract: Methods and systems disclosed herein enable tracking user actions by generating different visually scannable codes (e.g., QR codes) for combinations of user, operator, and action(s). Each visually scannable code may be stored with user action data and an operator identifier and linked to another visually scannable code corresponding to the user. When a visually scannable code is scanned, all data associated with the visually scannable code and data associated with other linked visually scannable codes is generated for display. By generating the visually scannable codes and storing the codes in a linked state, the system is able to provide quick and efficient data retrieval.

Abstract: Systems, devices, and methods for fileless information management are provided. A system includes a content-management server in communication with at least one client device via a computer network. The client device has a client user interface to concurrently display a content-editing area and a content card-management area. The content-management server stores content data and content card template metadata shareable between client devices. The content-management server stores programming instructions for a content card-management program for receiving, storing, and transmitting content data via content card templates. A content card template may include metadata associating content data stored in the memory with a content binding in the content-editing area of a client device.

Abstract: A computer-implemented method of verifying the integrity of part of a pre-image corresponding to a hash digest generated by hashing the preimage with a SHA-based hash function, wherein the pre-image comprises a first message and a second message, and wherein the method comprises: a) receiving an iteration input vector; b) obtaining a second sequence of blocks; c) generating a final iteration output vector by performing an iteration of the SHA-based hash computation for each of the second sequence of blocks in order of a respective position in the second sequence of blocks, wherein the iteration of the SHA-based hash computation performed on a first one of the second sequence of blocks is based on the obtained iteration input vector; and d) generating a candidate hash digest based on the final iteration output vector, the candidate hash digest being for comparison with the hash digest.

Abstract: A detergent product containing a detergent composition is provided.

Abstract: An atomic object confined in a particular region of a confinement apparatus is cooled via a simultaneous sideband and Doppler laser cooling operation. A controller controls first and second manipulation sources to provide first and second two-photon transition manipulation signals to the particular region. The controller controls a third manipulation source to provide a repump manipulation signal to the particular region. The first and second two-photon transition manipulation signals are collectively configured to cause the atomic object to undergo a red sideband transition from a first ground state to a second ground state. The repump manipulation signal is configured to repump the atomic object from the second ground state to the first ground state via an excited state. The repump manipulation signal is red detuned from a transition from the second ground state to the excited state by a repump detuning configured to cause Doppler cooling of the atomic object.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: A machine-learning classification system for a hosted data storage service classifies documents in storage domains of the hosted data storage service. A hosted data storage service can include isolated storage domains that are individually configured to provide domain access by an authorized entity for a domain and prohibit access to the domain by unauthorized entities. A machine-learned domain-specific classifier is associated with a storage domain and is configured to generate a classification label for documents of the entity associated with the respective storage domain. A training system is configured to generate a machine-learned domain-specific classifier using a subset of annotated documents from the selected storage domain.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: The invention features a headset, and systems including the headset, equipped with electrical sensors. The headset is suitable for use by a child and suitable for use in a gaming system, e.g., to train attention.

Abstract: The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The systems include a reactor vessel to degum, rinse, and dissolve the silk fibroin protein from silk inputs to obtain a purified silk fibroin-based solution. The reactor vessel may include a combination of inputs and outputs for introducing and removing different components used or generated during the disclosed processes. The systems may include any combination of heat exchangers, holding tanks, filtration modules, and post-treatment equipment as necessary to obtain the silk powder. The solutions and powders can be used to improve the post-harvest preservation of perishables and to improve the performance of packaging, including biodegradable packaging.

Abstract: The current invention relates to nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted protein degradation reagents and pharmaceutical compositions thereof and their utility as anti-cancer agents.

Abstract: A compliant end effector includes a robot mounting bracket and a component support member. The component support member includes a side surface and a top surface. A component clamping system includes a first clamp member operable to move toward the side surface of the component support member and a second clamp member operable to move toward the top surface of the component support member. A controller is operatively connected to the clamping system. The controller is configured to engage the first and second clamp members as the component gripping and manipulating system is in a set position and release the first clamp member and the second clamp member allowing a portion of a component held by the component clamping system to move with one or more degrees of freedom when the component gripping and manipulating system is moving to the set position.

Abstract: An electrical connector system includes a circuit card assembly that includes a host circuit board, an interposer, and a socket connector arranged in a circuit stack. The electrical connector system includes a cable assembly that has cables electrically connected to terminating ends of the interposer contacts. The electrical connector system includes a pluggable module having a mating end with a module circuit board mated with the socket contacts of the socket connector. The electrical connector system includes a loading mechanism operably coupled to the circuit card assembly operated to compress the socket contacts between the module circuit board and interposer contacts to create circuit paths between the module contacts and the interposer contacts through the socket contacts. The cables are electrically connected to the pluggable module through the interposer and the socket connector.

Abstract: Sheet product dispensers provided herein include a spindle mounted to a spindle mounting arm. A pressure plate positioned at least partially within the spindle mounting arm aligns with a roll of sheet product installed on the spindle. When the spindle mounting arm is in a dispensing state and the pressure plate is unextended, the pressure plate is configured to prevent rotation of the spindle mounting arm to a loading state, and, when the spindle mounting arm is in the dispensing state and the pressure plate is extended, the pressure plate is configured to allow transition of the spindle mounting arm to the loading state. Force from the roll of sheet product causes the pressure plate to remain unextended, and a sufficient amount of sheet product from the roll of sheet product having been depleted removes the force such that the pressure plate becomes extended.