Abstract: Compounds, methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNA-PK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNA-PK inhibitor disclosed herein.

Abstract: Mobile management method, system and client. The method includes receiving a DNS query for a host name from an application on a client; retrieving reputation data associated with the host name from a local cache on the client; determining a policy for the host name, which is associated with the host name and the reputation data associated with the host name; based on the determined policy for the host name, blocking attempted network flows to a host corresponding to the host name; sending at least attempted network flow metadata related to the blocked attempted network flows to a collector on the client; and transmitting the attempted network flow metadata in the collector to a VPN server pool via a VPN tunnel.

Abstract: The disclosure describes an earphone that include a biometric sensor, where the biometric sensor can detect levels of gas concentration. Where the gas levels are reported to a user if exceeding a threshold value and where the earphone includes a microphone, speaker, memory and a processor.

Abstract: An authentication server verifies the initiating device of a request for authentication is a trusted endpoint prior to proceeding with the authentication process to prevent an Adversary in the Middle (AiTM) attack on a deployed Multi-Factor Authentication (MFA) system. The server may verify that the initiating device is a trusted endpoint based on matching Internet Protocol (IP) addresses for the initiating device and a confirming device associated with an authorized user or by verifying the identity of the user based on video of the user captured by the initiating device. Verification that the initiating device is a trusted endpoint may be performed prior to sending a request for confirmation of the requestion for authentication to the confirming device or may be used to establish trust before issuing or updating a certificate to the initiating device for a certificate based authentication procedure.

Abstract: Provided herein are SARS-CoV-2 spike proteins and polypeptides (e.g., SARS-CoV-2 spike proteins and polypeptide immunogens (and immunogenic fragments and immunogenic variants thereof)) comprising at least one set of amino acid substitutions, and nucleic acid molecules encoding the same. Further provided herein are compositions (e.g., pharmaceutical compositions) and vaccines comprising the same for use in e.g., the prevention, treatment, and/or amelioration of a SARS-CoV-2 infection.

Abstract: A water heater including a cabinet having an inlet, an outlet, and a flow path disposed between the inlet and the outlet and having a plurality of upper and lower junctions to redirect the flow path. Each lower junction includes a drain port. A flow rate sensor measures the flow rate of the fluid through the flow path, an inlet temperature sensor measures an inlet temperature, an and outlet temperature sensor measures the outlet temperature. Heating elements are disposed along the flow path between the inlet and outlet temperature sensors, and intermediate temperature sensors are disposed adjacent respective heating elements to measure an intermediate temperature within the flow path. A controller operates the heating elements to heat a fluid within the flow path to a predetermined set point temperature based on the measurements of the flow rate sensor and temperature sensors.

Abstract: Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the cortex region of a patient's brain for treating opioid use disorder and substance use disorder. By stimulating this region of the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Abstract: As a farming machine travels through a field of plants, the farming machine operates in a normal operational state to perform one or more farming operations. The farming machine detects an operational failure of a component of the farming machine using measurements obtained from one or more sensors coupled to and monitoring the farming machine. The operational failure of the component impacts performance of a first farming operation of the farming operations. The farming machine configures the farming machine to operate in a remedial operational state. In the remedial operational state, the farming machine diagnoses the operational failure of the component using the obtained measurements. In the remedial operational state, the farming machine selects a solution operation to address the operational failure of the component based on the diagnosis. The farming machine performs the determined solution operation.

Abstract: Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to a patient's brain for the treatment of mild traumatic brain injury (mTBI) and post-concussion symptoms. By stimulating the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in symptoms and pain may be achieved relative to earlier treatment techniques. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Abstract: Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.

Abstract: Methods and systems disclosed herein enable tracking user actions by generating different visually scannable codes (e.g., QR codes) for combinations of user, operator, and action(s). Each visually scannable code may be stored with user action data and an operator identifier and linked to another visually scannable code corresponding to the user. When a visually scannable code is scanned, all data associated with the visually scannable code and data associated with other linked visually scannable codes is generated for display. By generating the visually scannable codes and storing the codes in a linked state, the system is able to provide quick and efficient data retrieval.

Abstract: The technology relates generally to an interactive avatar training system. The interactive avatar training system utilizes an interactive platform that allows at least two users, such as a trainer and a trainee, to be in interactive communication in a training program. The interactive avatar training system may assist generating a processed answer or response from the trainer to the trainee so that the answer presented to the trainee has high level of accuracy. Thus, the training efficiency and accuracy may be enhanced and improved.

Abstract: Systems, devices, and methods for fileless information management are provided. A system includes a content-management server in communication with at least one client device via a computer network. The client device has a client user interface to concurrently display a content-editing area and a content card-management area. The content-management server stores content data and content card template metadata shareable between client devices. The content-management server stores programming instructions for a content card-management program for receiving, storing, and transmitting content data via content card templates. A content card template may include metadata associating content data stored in the memory with a content binding in the content-editing area of a client device.

Abstract: A computer-implemented method of verifying the integrity of part of a pre-image corresponding to a hash digest generated by hashing the preimage with a SHA-based hash function, wherein the pre-image comprises a first message and a second message, and wherein the method comprises: a) receiving an iteration input vector; b) obtaining a second sequence of blocks; c) generating a final iteration output vector by performing an iteration of the SHA-based hash computation for each of the second sequence of blocks in order of a respective position in the second sequence of blocks, wherein the iteration of the SHA-based hash computation performed on a first one of the second sequence of blocks is based on the obtained iteration input vector; and d) generating a candidate hash digest based on the final iteration output vector, the candidate hash digest being for comparison with the hash digest.

Abstract: An atomic object confined in a particular region of a confinement apparatus is cooled via a simultaneous sideband and Doppler laser cooling operation. A controller controls first and second manipulation sources to provide first and second two-photon transition manipulation signals to the particular region. The controller controls a third manipulation source to provide a repump manipulation signal to the particular region. The first and second two-photon transition manipulation signals are collectively configured to cause the atomic object to undergo a red sideband transition from a first ground state to a second ground state. The repump manipulation signal is configured to repump the atomic object from the second ground state to the first ground state via an excited state. The repump manipulation signal is red detuned from a transition from the second ground state to the excited state by a repump detuning configured to cause Doppler cooling of the atomic object.

Abstract: A detergent product containing a detergent composition is provided.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: A machine-learning classification system for a hosted data storage service classifies documents in storage domains of the hosted data storage service. A hosted data storage service can include isolated storage domains that are individually configured to provide domain access by an authorized entity for a domain and prohibit access to the domain by unauthorized entities. A machine-learned domain-specific classifier is associated with a storage domain and is configured to generate a classification label for documents of the entity associated with the respective storage domain. A training system is configured to generate a machine-learned domain-specific classifier using a subset of annotated documents from the selected storage domain.