Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; R3 is C1-6alkyl or NH2; R4 is H or C1-6alkyl; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R5; R5 is halogen, C1-6alkyl, C1-6alkyl substituted by one ore more F, C1-6alkoxy, C1-6alkoxy substituted by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4.

Abstract: The invention provides methods for identifying agonists and antagonists of FabK polypeptides.

Abstract: Prokayrotic FABI polypeptides and DNA (RNA) encoding such FABI and a procedure for such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FABI for the treatment of infection, such as bacterial infections. Antagonists against such FABI and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FABI nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FABI and for detecting the polypeptide in a host.

Abstract: A cargo storage system (14), e.g. of a road freight semi-trailer (18) comprises a rectangular base (10) with telescopic support masts (12). The support masts (12), by means of height adjustment tables (82) and a rectangularly orientated support cable (70), are adapted to support a box-shaped flexible cover (50) in a raised position over the base (10). The support masts (12) may be retracted and/or the height adjustment cables (82) released to lower the cover (50) may engage against cargo loaded on the base (10). The cover includes a grid pattern of webbing straps integral therewith, which may be tensioned down so that the cover engages against and bears down upon the cargo to restrain the cargo in position. The cover (50) is removeable and foldable and the masts (12) removable for stowage thereof. The invention is also applicable to rigid vehicle, full trailer, intermodal and other freight applications.

Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.

Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.

Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.

Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl, R3 is C1-6alkyl or NH2: R4 is H or C1-6alkyl: A is and 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R5; R5 is halogen, C1-6alkyl, C1-6alkyl substituted by one ore more F, C1-6alkoxy, C1-6alkoxy substituted by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.

Abstract: A nitrogen containing transition metal complex having Formula (I), 1

Abstract: According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I), 1

Abstract: According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I), wherein R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R3 represents hydrogen, methyl (which may be in either the &agr; or &bgr; configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and {overscore (-----)} represents a single or a double bond; and salts and solvates thereof together with a long-acting &bgr;2-adrenoreceptor agonist which formulation has a therapeutically useful effect in the treatment of inflammatory disorders of the respiratory tract over a period of 24 hours or more.

Abstract: According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I), 1

Abstract: The present invention relates to a method of determining the relative proportions of gases in a mixture, such that the relative proportions of N gases are determined using N-1 sensors, not all of which are specific to a particular gas. In the preferred embodiment, oxygen and carbon dioxide are measured in the presence of nitrogen by measuring magnetic susceptibility and speed of sound. The described method of gas analysis leads to very fast response times and exceptional stability, making the technology suitable for breath-by-breath analysis of respired air. Notably, the method does not require high-temperature components, electrochemical cells, or consumable components.

Abstract: Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.

Abstract: The present invention relates to a method of determining the relative proportions of gases in a mixture, such that the relative proportions of N gases are determined using N−1 sensors, not all of which are specific to a particular gas. In the preferred embodiment, oxygen and carbon dioxide are measured in the presence of nitrogen by measuring magnetic susceptibility and speed of sound. The described method of gas analysis leads to very fast response times and exceptional stability, making the technology suitable for breath-by-breath analysis of respired air. Notably, the method does not require high-temperature components, electrochemical cells, or consumable components.

Abstract: A process for the preparation of a supported catalyst is disclosed, comprising the steps of

Abstract: FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the treatment of infection, particularly bacterial infections. Antagonists against such FabD and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FabD nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Fab (Fatty acid biosynthesis) and for detecting the polypeptide in a host.

Abstract: The present invention relates to a method of determining the relative proportions of gases in a mixture, such that the relative proportions of N gases are determined using N-1 sensors, not all of which are specific to a particular gas. In the preferred embodiment, oxygen and carbon dioxide are measured in the presence of nitrogen by measuring magnetic susceptibility and speed of sound. The described method of gas analysis leads to very fast response times and exceptional stability, making the technology suitable for breath-by-breath analysis of respired air. Notably, the method does not require high-temperature components, electrochemical cells, or consumable components.

Abstract: The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.