Abstract: System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same genetic markers as the patient. An alert containing such information is displayed at a healthcare provider system.

Abstract: System and methods for providing laboratory-based authorization of genetic testing are disclosed. An order for genetic testing is received from an electronic health record (“EHR”) system at a laboratory information system (“LIS”). A prior authorization request is automatically generated at the LIS from data parsed from the order and retrieved from the EHR and sent to a prior authorization provider. If a patient responsibility amount returned to the LIS is below a threshold, testing proceeds. If the patient responsibility amount is above the threshold, an electronic call center request is generated and the patient is contacted to obtain payment. If a billing consent is not obtained, the specimen for the order is destroyed.

Abstract: There are disclosed fault detection circuits and methods for an N-to-1 Dickson topology hybrid DC-DC power converter. A short circuit fault detection circuit comprises: first and second measuring circuits configured to measure first and second voltages, Vsw1, Vsw2, at the switching node in the first and second state; first and second calculation circuits configured to calculate first and second absolute error voltage as an absolute difference of the respective first and second voltages in one operating cycle (Vsw1[n?1], Vsw2[n?1]) and in a next subsequent operating cycle (Vsw1[n], Vsw2[n]); and first and second fault circuits configured to provide first and second fault outputs indicative of a fault in response to the respective first or second absolute error voltage exceeding a short-circuit-trip level. Open circuit fault detection circuits and methods are also disclosed.

Abstract: A switching power regulator and method for recovering the regulator from an unregulated state while preventing overshoot of an output voltage is provided. The regulator includes a dropout detector, a sample-and-hold circuit, a voltage offset circuit and a soft start circuit. When the regulator enters an unregulated state, the dropout detector detects when a pulse width modulation (PWM) signal stops toggling. The sample-and-hold circuit and soft start circuit are used to effectively clamp the voltage at the output of an error amplifier. This causes the output of the error amplifier to regulate around a desired voltage so that the regulator recovers from the unregulated state with little or no overshoot of the output voltage. In another embodiment, a method for recovering from the unregulated state is provided.

Abstract: System and methods for automating preauthorization of genetic efficacy testing with prescription dispensation are provided. Coverage requests for medicines are received from pharmacy systems. Databases are queried to retrieve policy rules for the coverage requests. A coverage decision analysis is performed and where an associated medication is otherwise approved for coverage and where genetic efficacy testing is available for the associated medication, a prior authorization for such genetic efficacy testing is automatically generated and included with which is transmitted together with an approval of coverage decision to a requesting one of said number of pharmacy systems.

Abstract: System and methods for providing laboratory-based authorization of genetic testing are disclosed. An order for genetic testing is received from an electronic health record (“EHR”) system at a laboratory information system (“LIS”). A prior authorization request is automatically generated at the LIS from data parsed from the order and retrieved from the EHR and sent to a prior authorization provider. If a patient responsibility amount returned to the LIS is below a threshold, testing proceeds. If the patient responsibility amount is above the threshold, an electronic call center request is generated and the patient is contacted to obtain payment. If a billing consent is not obtained, the specimen for the order is destroyed.

Abstract: Systems and methods for providing a real time visualization of scattered radiation in an operating room are provided. A number of visualization devices such as augmented reality (“AR”) tracking devices, electronic displays, or projection devices are in electronic communication with a controller and configured to display a visualization of scattered radiation. Position data is received from the position sensors associated with individuals in the operating room, the AR tracking devices, radiation producing medical equipment, or an operating table and the visualization is adjusted accordingly.

Abstract: A level shifter comprising: a translation circuit having two input lines and two output lines and configured to receive a differential signal in a low-voltage domain on the two input lines and provide a second differential signal, being a copy of the first differential signal, in a high-voltage domain on the two output lines; and a combiner circuit configured to convert the second differential signal into a single-ended signal at a high-voltage shifter output; wherein the combiner circuit comprises a two-input Muller C-element circuit wherein one input is inverted. Corresponding methods are also disclosed.

Abstract: Systems and methods monitoring progress of a medical procedure by radiation exposure are provided. Locations of radiation producing and scattering items of medical equipment are received at a controller. Locations of individuals assisting with the medical procedure are received at the controller by way of tracking devices worn by the individuals during the medical procedure. The controller receives indication of when the radiation producing item(s) are activated and develops a radiation scatter intensity field. An analytical subsystem determines an estimated exposure level for each individual based on their position within the radiation scatter intensity field at each instance the radiation producing device is activated, which are compared to a benchmark. Where the estimated exposure level exceeds the benchmark, an intervention subsystem provides an intervention.

Abstract: System and methods for providing enhanced patient updates to facilitate precision therapy are provided. Medical information is received from a transmitting one of a number of electronic health records (“EHR”) systems at a laboratory information system (“LIS”). Where the received medical information comprises prescribed medications designated as ineffective or undereffective for the particular patient based on a retrieved genetic testing results for the patient, the EHR systems are instructed to designate the prescribed medications as an allergy. Where the received medical information comprises new diagnosis information eligible for genetic testing based on retrieved eligibility rules for the particular patient, a suggested order is transmitted to the transmitting EHR system.

Abstract: Systems and methods for providing a real time visualization of scattered radiation in a medical facility are provided. A number of visualization devices such as augmented reality (“AR”) tracking devices, electronic displays, or projection devices are in electronic communication with a controller and configured to display a visualization of scattered radiation. Position data is received from the position sensors associated with individuals in the medical facility, the AR tracking devices, radiation producing medical equipment, or radiation scattering medical equipment, and the visualization is adjusted accordingly.

Abstract: Disclosed are switched-mode DC-DC power converter modules, SMPC controllers, and distributed-control multiphase SMPC systems. The controller comprises: a reference clock; a synchronisation input configured to receive a first synchronisation signal; a synchronisation output configured to transmit a second synchronisation signal; a control unit configured to control the operation of the SMPC module with a phase determined by the reference clock signal or the first synchronisation signal; a delay line configured to generate the second synchronisation signal by adding a delay to the selected one of the first synchronisation signal and the reference clock signal; a fault detection terminal; a memory configured to store a datum corresponding to a number N of SMPCs in the system; and a delay calculation module configured to calculate the delay in dependence on the datum and the signal at the fault-detection terminal. Associated methods are also disclosed.

Abstract: A method for current limiting an operational amplifier includes sensing a first current through a first branch of the operational amplifier. The first branch conducts the first current from a limited current supply connected to an operational amplifier output. The first current is compared to a reference current to generate a regulation signal. A variable current source is controlled with the regulation signal. An output current of a transconductance amplifier is limited with the variable current source to limit the first current in response thereto.

Abstract: A method for current limiting an operational amplifier includes sensing a first current through a first branch of the operational amplifier. The first branch conducts the first current from a limited current supply connected to an operational amplifier output. The first current is compared to a reference current to generate a regulation signal. A variable current source is controlled with the regulation signal. An output current of a transconductance amplifier is limited with the variable current source to limit the first current in response thereto.

Abstract: Systems and methods for providing a real time visualization of scattered radiation in an operating room are provided. A number of visualization devices such as augmented reality (“AR”) tracking devices, electronic displays, or projection devices are in electronic communication with a controller and configured to display a visualization of scattered radiation. Position data is received from the position sensors associated with individuals in the operating room, the AR tracking devices, radiation producing medical equipment, or an operating table and the visualization is adjusted accordingly.

Abstract: System and methods for preventing the coverage or fill of ineffective medications are provided. Genetic efficacy testing results are received at a pharmacy benefits manager (“PBM”) system from a laboratory information system. Medications reported as ineffective in the testing results are flagged as an allergy in an electronic patient record. Requests for coverage of medications are received at the PBM system from a dispensing pharmacy system and electronic notifications are issued to the dispensing pharmacy system where the medication is flagged as an allergy at the PBM system to prevent the flagged medication from being filled.

Abstract: A method for high-speed voltage level translation includes biasing a high-voltage (HV) gate of an HV transistor to an intermediate voltage with a bias device. A low-voltage (LV) transistor is activated with a positive voltage transition applied to an LV gate of the LV transistor, wherein the HV transistor is connected in series between an output and an LV drain of the LV transistor. The intermediate voltage is bootstrapped to a bootstrapped voltage in response to the positive voltage transition on the LV gate coupled to the HV gate through a capacitor therebetween. The output is discharged. A time constant, defined by a resistance of the bias device and a capacitance of the capacitor, is greater than a minimum time constant, thereby maintaining the bootstrapped voltage on the HV gate at or above a drive voltage for a minimum period to discharge the output to a minimum voltage.

Abstract: There are disclosed fault detection circuits and methods for an N-to-1 Dickson topology hybrid DC-DC power converter. A short circuit fault detection circuit comprises: first and second measuring circuits configured to measure first and second voltages, Vsw1, Vsw2, at the switching node in the first and second state; first and second calculation circuits configured to calculate first and second absolute error voltage as an absolute difference of the respective first and second voltages in one operating cycle (Vsw1[n?1], Vsw2[n?1]) and in a next subsequent operating cycle (Vsw1[n], Vsw2[n]); and first and second fault circuits configured to provide first and second fault outputs indicative of a fault in response to the respective first or second absolute error voltage exceeding a short-circuit-trip level. Open circuit fault detection circuits and methods are also disclosed.

Abstract: A voltage regulation system has a voltage regulator, a current-limiting circuit, and a feed-forward circuit. The voltage regulator regulates an output voltage to a desired voltage level. The current-limiting circuit controls an output current of the voltage regulator to a desired current level. The feed-forward circuit, which has a fast response time, controls an inrush current in the output current caused by a decrease in an output voltage.

Abstract: Disclosed are switched-mode DC-DC power converter modules, SMPC controllers, and distributed-control multiphase SMPC systems. The controller comprises: a reference clock; a synchronisation input configured to receive a first synchronisation signal; a synchronisation output configured to transmit a second synchronisation signal; a control unit configured to control the operation of the SMPC module with a phase determined by the reference clock signal or the first synchronisation signal; a delay line configured to generate the second synchronisation signal by adding a delay to the selected one of the first synchronisation signal and the reference clock signal; a fault detection terminal; a memory configured to store a datum corresponding to a number N of SMPCs in the system; and a delay calculation module configured to calculate the delay in dependence on the datum and the signal at the fault-detection terminal. Associated methods are also disclosed.