Patents by Inventor John Ralph

John Ralph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160187345
    Abstract: Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
    Type: Application
    Filed: December 31, 2015
    Publication date: June 30, 2016
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: John Ralph, Steven D Karlen, Fachuang Lu, Dharshana Padmakshan
  • Publication number: 20160046955
    Abstract: The invention relates to nucleic acids encoding a p-coumaroyl-CoA:monolignol transferase and to inhibitory nucleic acids adapted to inhibit the expression and/or translation of a p-coumaroyl-CoA:monolignol transferase RNA. Inhibition of p-coumaroyl-CoA:monolignol transferase in plants improves the incorporation of monolignol ferulates into the lignin of plants, giving rise to plant biomass that is more easily processed into useful products such as paper and biofuels.
    Type: Application
    Filed: December 14, 2012
    Publication date: February 18, 2016
    Applicants: Board of Trustees of Michigan State University, Wisconsin Alumni Research Foundation, The Board of Trustees of Illinois State University
    Inventors: Curtis Wilkerson, John Ralph, Saunia Withers, John Sedbrook
  • Publication number: 20150313221
    Abstract: Antimicrobial diferulates, compositions containing same, and uses of same for inhibiting growth of microorganisms. The antimicrobial diferulates can be used alone or in combination with other antimicrobial agents to inhibit growth of microorganisms such as fungi, oomycetes, and other microorganisms having a glucan-containing cell wall. The antimicrobial diferulates can be included in pharmaceutical compositions for treatment of animals or included in agricultural compositions for treatment of plants, crops, and soils.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jeff S. Piotrowski, Fachuang Lu, Mehdi Kabbage, John Ralph, Robert C. Landick
  • Publication number: 20150265701
    Abstract: The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Inventor: Stephen John Ralph
  • Publication number: 20150252864
    Abstract: Motion-damping systems and methods that include motion-damping systems are disclosed herein. The motion-damping systems are configured to damp relative motion between a base structure and an attached component that define a gap therebetween. The systems include an at least substantially rigid tubular structure that defines an internal volume and extends within the gap. The systems also include a magnetic assembly and a magnetically active body. One of the magnetic assembly and the magnetically active body is located within the tubular structure and the other of the magnetic assembly and the magnetically active body is operatively attached to a selected one of the base structure and the attached component. The magnetic assembly is in magnetic communication with the magnetically active body such that a magnetic interaction therebetween resists motion of the attached component relative to the base structure. The methods include dissipating energy with the motion-damping system.
    Type: Application
    Filed: December 12, 2013
    Publication date: September 10, 2015
    Applicant: The Boeing Company
    Inventors: John Ralph HULL, Michael STRASIK, Thomas H. MARTIG
  • Publication number: 20150167777
    Abstract: Motion-damping systems and methods that include motion-damping systems are disclosed herein. The motion-damping systems include a flexible body that is configured to extend within a gap that is defined between a base structure and an attached component. The motion-damping systems further include a magnetic assembly and a ferromagnetic body. One of the magnetic assembly and the ferromagnetic body is located within the flexible body and the other of the magnetic assembly and the ferromagnetic body is operatively affixed to a selected one of the base structure and the attached component. The magnetic assembly and the ferromagnetic body are oriented such that a magnetic force therebetween retains the flexible body in physical contact with the selected one of the base structure and the attached component. The methods include methods of installing and/or operating the motion-dampening systems.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 18, 2015
    Applicant: The Boeing Company
    Inventors: John Ralph HULL, Michael Strasik, Thomas H. Martig
  • Patent number: 9050352
    Abstract: The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: June 9, 2015
    Inventor: Stephen John Ralph
  • Publication number: 20150136327
    Abstract: A composite tube is made by applying a mixture of individual reinforcing fibers and a resin onto the interior cylindrical wall of the spinning mandrel.
    Type: Application
    Filed: January 24, 2015
    Publication date: May 21, 2015
    Inventors: John Ralph Hull, Mark Alan Negley, Michael Strasik, John A. Mittleider
  • Publication number: 20150125816
    Abstract: A dental instrument device includes a middle body with two ends, a pair of removable instrument tips, a pair of securing collets, and a pair of removable end caps. Each end of the middle body terminates in a middle body/instrument tip connection interface that receives a right-handed instrument tip only in a first orientation and a left-handed instrument tip only in a second orientation differing from the first orientation. The removable instrument tips have a similar middle body/instrument tip connection interface, and a working instrument end with a right-handed or a left-handed orientation. A right-handed instrument tip is releasably connected to the first middle body/instrument tip connection interface, and a left-handed instrument tip is releasably connected to the second middle body/instrument tip connection interface, with the right-handed and left-handed orientations being visually distinguishable one from the other by casual observation of an ordinary observer.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 7, 2015
    Inventors: John Ralph Ladd, Joseph G. Kinney
  • Patent number: 8992711
    Abstract: A composite tube is made by applying a mixture of individual reinforcing fibers and a resin onto the interior cylindrical wall of the spinning mandrel.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: March 31, 2015
    Assignee: The Boeing Company
    Inventors: John Ralph Hull, Mark Alan Negley, Michael Strasik, John A. Mittleider
  • Publication number: 20150021241
    Abstract: A screen support frame comprising, a perimeter disposed in a horizontal plane, defining a vertical direction normal to said plane, said perimeter reinforced by an arrangement of reinforcing wires, said arrangement comprising a first array of substantially parallel structural wires extending between opposing regions of the perimeter in a first horizontal plane, a second array of substantially parallel structural wires extending between opposing regions of the perimeter in a second horizontal plane, said first and second arrays of structural wires being aligned at an angle to each other and in contact with each other thus forming a plurality of contact points between structural wires of the first and second array respectively, the arrangement further comprising at least one additional structural wire, said additional structural wire extending between opposing regions of the perimeter and being positioned parallel to, and substantially vertically spaced from, a wire in the first array of structural wires, and in
    Type: Application
    Filed: February 18, 2013
    Publication date: January 22, 2015
    Inventor: Andrew John Ralph
  • Publication number: 20150020234
    Abstract: The invention relates to isolated nucleic acids encoding a feruloyl-CoA:monolignol transferase and feruloyl-CoA:monolignol transferase enzymes. The isolated nucleic acids and/or the enzymes enable incorporation of monolignol ferulates into the lignin of plants, where such monolignol ferulates include, for example, p-coumaryl ferulate, coniferyl ferulate, and/or sinapyl ferulate. The invention also includes methods and plants that include nucleic acids encoding a feruloyl-CoA:monolignol transferase enzyme and/or feruloyl-CoA:monolignol transferase enzymes.
    Type: Application
    Filed: October 4, 2012
    Publication date: January 15, 2015
    Inventors: Curtis Wilkerson, John Ralph, Saunia Withers
  • Patent number: 8806950
    Abstract: A method and apparatus for an electromagnetic acoustic transducer. An apparatus comprises a conductive material and a current inducer. The conductive material is configured to generate a magnetic field, wherein the magnetic field has magnetic flux lines that are substantially fixed and the conductive material has a temperature that is equal to or less than a critical temperature at which the conductive material has substantially zero electrical resistance. The current inducer is configured to cause an electric current to flow in a test object that interacts with the magnetic field, wherein the electric current has a frequency that generates an acoustic wave in the test object.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: August 19, 2014
    Assignee: The Boeing Company
    Inventors: John Ralph Hull, Michael Strasik, Richard H. Bossi
  • Patent number: 8752795
    Abstract: An aircraft component includes an exterior surface exposed to external airflow during flight, an interior surface, and a locally thickened fastening portion between the exterior and interior surfaces. An area of the interior surface on the locally thickened fastening portion is substantially parallel to an area of the exterior surface on the locally thickened fastening portion. The thickness of the aircraft component between the exterior surface and the interior surface is greater at the fastening portion than at an area surrounding the fastening portion. When the additional component is fastened to the substantially parallel area of the interior surface on the fastening portion with mechanical fasteners, the mechanical fasteners do not penetrate the exterior surface.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: June 17, 2014
    Inventor: John Ralph Stewart, III
  • Publication number: 20140157706
    Abstract: The invention relates generally to building construction, and more particularly to studs for use in wall panels used in the construction of foundation walls and upper floor exterior walls. The invention provides a structural wall system to support building loads and lateral earth pressure from adjacent ground, said system comprising a wall assembly using plurality of studs preferably formed from metal located side by side and each having a cross section comprising an orthogonal lip section with interior flange section, a web section, and an exterior diaphragm section orthogonal to the web section and having a first recessed shoulder on the open distal end and a second recessed shoulder on the bend line integral with the web section. The wall system may be assembled using a standard steel channel as a starting point. The stud diaphragm of the present invention extends laterally from the web portion with the distal edge to be aligned with and fastened to the standard steel channel.
    Type: Application
    Filed: December 2, 2013
    Publication date: June 12, 2014
    Inventors: John Ralph Naccarato, Joseph Anthony Severini
  • Publication number: 20140096626
    Abstract: A system to determine the mass of a precious metal existing with an alloy specimen where the purity concentration of the precious metal within the alloy is known by a user is provided. The system includes an assembly for weighing the alloy specimen, the assembly including an adjustable setting to permit the user to input the known purity concentration, a processor programmed to calculate the mass of the precious metal based upon the weight of the alloy and the purity concentration, and a display for visually displaying the precious metal mass to the user.
    Type: Application
    Filed: September 4, 2013
    Publication date: April 10, 2014
    Inventor: JOHN RALPH BICH
  • Patent number: 8685672
    Abstract: A method of manufacturing modified lignin and the resulting non-natural modified lignin product in which a lignin-producing polymerization reaction is performed using a polymerizable monomer having the structure: wherein at least one of the polymerizable monomers is incorporated into the resulting lignin.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 1, 2014
    Assignees: Wisconsin Alumni Research Foundation, The United States of America as Represented by the Secretary of Agriculture
    Inventors: John H. Grabber, John Ralph
  • Publication number: 20140011984
    Abstract: Described is an isolated lignified plant cell wall including lignin, wherein the lignin includes a ferulate residue incorporated therein, such as from coniferyl ferulate and/or sinapyl ferulate. Also described is a method to make the isolated lignified plant cell wall, and the lignin produced by the method.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: John Ralph, John H. Grabber, Ronald D. Hatfield, Fachuang Lu
  • Patent number: 8598145
    Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In one aspect the invention concerns mitochondrially delivered pro-oxidant anti-cancer compounds that generate reactive oxygen species and induce apoptosis of cancerous cells. The delivery moiety can be a lipophilic cation and the pro-oxidant vitamin E analogue, such as ?-tocopheryl succinate, ?-tocopheryl maleate, ?-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (?-tocopheryloxyacetic acid).
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 3, 2013
    Inventors: Stephen John Ralph, Jiri Neuzil
  • Patent number: 8569465
    Abstract: Described is an isolated lignified plant cell wall including lignin, wherein the lignin includes a ferulate residue incorporated therein, such as from coniferyl ferulate and/or sinapyl ferulate. Also described is a method to make the isolated lignified plant cell wall, and the lignin produced by the method.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: October 29, 2013
    Assignees: Wisconsin Alumni Research Foundation, The United States of America, as represented by the Secretary of Agriculture
    Inventors: John Ralph, John H. Grabber, Ronald D. Hatfield, Fachuang Lu