Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.

Abstract: A retrievable filter screen assembly is provided, comprising a nonmagnetic carrier sub suspended from a first pulling tool connected to a wireline; a nonmagnetic filter screen disposed within the carrier sub, and having a first end supported by a bell housing operatively positioned within the carrier sub, and wherein the first end of the filter screen can be disconnected from the bell housing via shear pins; wherein the filter screen further includes a second end adapted to receive a second pulling tool positionable within the carrier sub, and wherein the pulling tool is connectable to an MWD source.

Abstract: A method and network for transmitting a message from a sender to a recipient wherein the sender has no previous knowledge of the recipient's identity. A method is provided for registering a user with a web-enabled database service by providing correlating data on the user's identity and vehicle license plate number and/or other vehicle identifying information. A sender observing a vehicle can send a message to the recipient by logging onto the service and sending a message including the license plate number of the vehicle or other vehicle identifying information. The service will forward the message to the recipient by looking up the vehicle information, discerning the most appropriate communications method(s), and causing the message to be transmitted to the recipient or stored for later delivery.

Abstract: A curable material delivery cannula device and method are disclosed. The device includes a cannula and a hub. The cannula includes an open proximal end, a deflectable segment forming a plurality of pre-set curves, each of which corresponds to a pre-determined temperature of the cannula, a lumen, and side orifice(s) adjacent, and proximally spaced from, the distal end and fluidly connected to the lumen. When distally extended from the guide cannula, and upon being heated to a predetermined temperature (before, during, or after extension), the deflectable segment assumes a curved shape, which may be used to create a void in the bone for receiving curable material. The distal cannula end includes a blunt tip for non-traumatic interface with bodily material. During use, curable material, such as bone cement, is delivered from the side orifice(s) in a radial direction relative to the lumen.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: A portable, light-activated, mist sprayer system comprising direct current power supply, an ambient light sensor, electronic circuitry that evaluates an electrical signal received from the light sensor to determine whether a “dusk” or “dawn” light condition exists; a container of treating fluid at a desired concentration; a motor and pump that are activated at the appropriate time as determined by the sensed light condition; at least one sprayer nozzle that will dispense a mist containing the treating fluid whenever the pump is operating; and a timer that turns off the pump after a preset interval to terminate the spraying cycle. A preferred utility for the system of the invention is spraying dilute solutions of insecticide or insect repellent during the periods of significant insect activity that typically occur around dusk and dawn. An RF receiving unit is also disclosed for optional activation using a remote transmitter.

Abstract: An apparatus and associated method for constructing prefabricated foam panels is provided. While making a longitudinal pass over a foam block, the apparatus flattens the foam block, cuts longitudinal kerfs in the foam block, and draws metal studs into the kerfs. The apparatus comprises a unique, heated blade having a shape similar to the cross section of a metal stud. The blade kerfs foam blocks, including blocks made of recycled or low-grade foam. The associated method includes kerfing the foam blocks by passing the blade through the foam blocks and drawing metal studs into the kerfs.

Abstract: A method for binding data in an application. An expression is created via a framework based on input from a developer. The expression is received at an expression engine wherein the expression describes a relation between a first property of a first data of the application to a first property of a second data of the application. A binding is created between the first data and the second data based on the relation via the expression engine. The first property of the second data is changed based on a change to the first property of the first data wherein the changing occurs because of the binding. The receiving the expression, the creating the binding, and the changing the first property are orchestrated via the framework to manage when the expression is executed in the application.

Abstract: A computer-usable storage medium having instructions embodied therein that when executed cause a computer system to perform a method for using an application platform for designing an application. An interface for developing an application is provided at a computer system. A plurality of components are provided at the interface for use in visually designing the application. A selection of a component from the plurality of components is received at the interface. A placement of the component in the application is received within the interface. The application is compiled with the component and the placement of the component such that the application executes natively on a target processor, and wherein the application is bound directly to a native graphics library associated with the target processor.

Abstract: An apparatus and method for introducing material into an injection site of a patient is disclosed. The device includes a cannula and a carrier. The cannula is inserted into an injection site of a patient. The carrier is connected to an injector containing a volume of material. Material may be pre-loaded into the carrier so that the material is delivered to a distal end of the carrier from the injector and the carrier is thus pre-loaded with material. A portion of the distal end of the pre-loaded carrier is inserted into the cannula and material is delivered to an injection site. The supply section can be rotatable with respect to the longitudinal axis of the inner section.

Abstract: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more ligation probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties. When such probes have bound to the target in the proper orientation, they are able to undergo a spontaneous chemical ligation reaction that yields a ligation product that is directly detected or that is amplified to produce amplicons that are then detected. The present invention also provides methods to stabilize sample RNA so that degradation does not significantly affect the results of the analysis.

Abstract: A method and network for transmitting a message from a sender to a recipient wherein the sender has no previous knowledge of the recipient's identity. A method is provided for registering a user with a web-enabled database service by providing correlating data on the user's identity and vehicle license plate number and/or other vehicle identifying information. A sender observing a vehicle can send a message to the recipient by logging onto the service and sending a message including the license plate number of the vehicle or other vehicle identifying information. The service will forward the message to the recipient by looking up the vehicle information, discerning the most appropriate communications method(s), and causing the message to be transmitted to the recipient or stored for later delivery.

Abstract: An exhaust system for a use with an engine is provided. The exhaust system may have an exhaust manifold configured to direct exhaust from the engine, and a main turbocharger connected to receive exhaust from the exhaust manifold. The exhaust system may also have a recirculation turbocharger having a compressor connected to receive exhaust from the exhaust manifold in parallel with the main turbocharger, and a turbine connected to receive exhaust from the main turbocharger to drive the compressor. The exhaust system may further have a control valve located downstream of the recirculation turbocharger to regulate exhaust flow through the compressor.

Abstract: A curable material delivery cannula device and method are disclosed. The device includes a cannula and a hub. The cannula includes an open proximal end, a deflectable segment forming a plurality of pre-set curves, each of which corresponds to a pre-determined temperature of the cannula, a lumen, and side orifice(s) adjacent, and proximally spaced from, the distal end and fluidly connected to the lumen. When distally extended from the guide cannula, and upon being heated to a predetermined temperature (before, during, or after extension), the deflectable segment assumes a curved shape, which may be used to create a void in the bone for receiving curable material. The distal cannula end includes a blunt tip for non-traumatic interface with bodily material. During use, curable material, such as bone cement, is delivered from the side orifice(s) in a radial direction relative to the lumen.

Abstract: A system for stabilizing a superior vertebra relative to an inferior vertebra includes a plate having a first surface for mating with the superior and inferior vertebra and a second surface opposite the first surface. The plate has a first hole configured for overlying the superior vertebra and a second hole configured for overlying the inferior vertebra. An alignment instrument has a leading portion and a trailing portion. The leading portion has a securing mechanism configured for removable attachment to a fastening mechanism of the plate. The alignment instrument also includes an alignment prong extending past the first surface of the plate when the plate is attached to the fastening mechanism. The alignment prong provides tactile information to the trailing portion of the alignment instrument for use in positioning the plate with respect to the superior and inferior vertebra.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: There is disclosed herein a method of increasing bone density, maintaining bone density and/or inhibiting loss of bone density and/or reducing osteochondral defects in an animal comprising administering to an animal an effective amount of a composition containing: vitamin K1, vitamin K2 or a mixture of vitamin K1 and vitamin K2, together with a physiologically acceptable carrier, incipient and/or diluent. Various compositions including vitamin K are also disclosed.

Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

Abstract: An apparatus and method for introducing material into an injection site of a patient is disclosed. The device includes a cannula and a carrier. The cannula is inserted into an injection site of a patient. The carrier is connected to an injector containing a volume of material. Material may be pre-loaded into the carrier so that the material is delivered to a distal end of the carrier from the injector and the carrier is thus pre-loaded with material. A portion of the distal end of the pre-loaded carrier is inserted into the cannula and material is delivered to an injection site. The supply section can be rotatable with respect to the longitudinal axis of the inner section.