Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.

Abstract: Biaryl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such biaryl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

Abstract: A data storage cartridge having an data storage device, such as an encased magnetic disk drive assembly, is, in one embodiment, of generally an exterior dimensional form factor of a tape cartridge having a leader block with a hole therethrough for engagement by a threading pin. To distinguish the cartridge from a tape cartridge, the cartridge shell comprises a blocking portion at the location of the leader block hole. A transfer station both identifies the cartridge and indicates the presence of the cartridge at an end of travel in a cartridge receiver, employing an optical source and an opposed sensor directed toward the leader block hole when a cartridge is at the end of travel. In another embodiment, an encased magnetic disk drive assembly is supported and mounted in a cartridge shell by a shock mount.

Abstract: A handle for speed winding a strap back onto a belt winch having a ratchet mechanism, a winch drum and an annular cylinder is described. The speed handle generally includes an elongated arm having a grip on the upper surface adjacent the first end and a handle drum on the lower surface adjacent the second end. The handle drum includes a tapered end and is adapted to fit into the annular cylinder of a belt winch. The handler drum includes a protrusion with a tapered end, adapted to fit into an aperture on the annular cylinder. Once placed on the belt winch, the speed handle allows the user to rapidly rewind a strap back onto the winch drum.

Abstract: A shutter mechanism is provided at an access opening in a portable data storage cartridge. Clamshell shutters meet at a common junction in the access opening. Actuation paddles positioned at the clamshell shutters are arranged to, when engaged by actuation pins, pivot the respective clamshell shutters in opposite directions away from the common junction, to expose the access opening. The clamshell shutters are mounted such that, when pivoted away from the common junction, each clamshell shutter remains within the cartridge housing.

Abstract: A cartridge loading apparatus has at least one movable member with a pin to engage a notch of a cartridge and has a reversible motor. A compliant link has a longitudinal leaf spring resilient beam, and has a laterally extending arm at one end of the beam, forming an “L” shape. The movable member and the motor apparatus are coupled at axes respectively at the other end of the beam and at an end of the arm. Thus, a compression force provides a rotational torque at the arm which flexes the beam outwardly away from a straight line between the axes; and a tension force provides a rotational torque to flex the beam inwardly.

Abstract: An indicator comprises a rotary device in the form of a right cylinder arranged to be rotatable in a chamber of a portable data storage cartridge, which has an exterior wall opening to the chamber. A peripheral surface of the rotary device has an encoded pattern of at least one cylindrical surface and a plurality of facets interrupting the cylindrical surface(s). The facets are located at various axial positions, and at various angularly spaced rotational positions, such that, at differing rotational positions of the rotary device, at least one or none of the facets is positioned at the exterior opening.

Abstract: An alarm monitoring and electrical interface panel provides DC power to plural devices in a system as well as power and analog and/or discrete alarms to a system alarm controller in monitoring power provided to the devices within the system. The analog alarms include a first LED which turns off when input power to the electrical interface panel is lost and a second LED which turns off when output power to the device being controlled is lost such as due to a failure of the electrical interface panel. Also included is an overcurrent protection feature which limits the current provided to a powered device as well as the current provided to the system alarm controller. In the discrete alarm approach, a DC current is applied to the alarm signal for powering a device being controlled in the system. If power is lost, a third LED is turned off providing a visual indication of power failure.

Abstract: An absorbent garment having a pant-like configuration is constructed with strategically placed leg elastic, resulting in an aesthetically pleasing, finished look at the leg openings. Such strategic placements include securing the leg elastic to an outer cover and folding the outer cover over the elastic; or placing the elastic between a liquid-permneable body side liner and the outer cover and folding the outer cover over the elastic and securing the outer cover to the body side liner; or folding the outer cover more than once around the elastic. In any case, the distance between the leg elastic is nearly equal to the width dimension of the outer cover of the finished product. In addition to being aesthetically pleasing, the finished product eliminates the chance of exposing the leg elastic to the user. In an alternate embodiment, portions of the outer cover can extend laterally beyond an absorbent layer, thereby serving as seamless leak guards.

Abstract: A cartridge loading apparatus has at least one movable member with a pin to engage a notch of a cartridge and has a reversible motor. A compliant link has a longitudinal leaf spring resilient beam, and has a laterally extending arm at one end of the beam, forming an “L” shape. The movable member and the motor apparatus are coupled at axes respectively at the other end of the beam and at an end of the arm. Thus, a compression force provides a rotational torque at the arm which flexes the beam outwardly away from a straight line between the axes; and a tension force provides a rotational torque to flex the beam inwardly.

Abstract: A shutter mechanism is provided at an access opening in a portable data storage cartridge. Clamshell shutters meet at a common junction in the access opening. Actuation paddles positioned at the clamshell shutters are arranged to, when engaged by actuation pins, pivot the respective clamshell shutters in opposite directions away from the common junction, to expose the access opening. The clamshell shutters are mounted such that, when pivoted away from the common junction, each clamshell shutter remains within the cartridge housing.

Abstract: An indicator comprises a rotary device in the form of a right cylinder arranged to be rotatable in a chamber of a portable data storage cartridge, which has an exterior wall opening to the chamber. A peripheral surface of the rotary device has an encoded pattern of at least one cylindrical surface and a plurality of facets interrupting the cylindrical surface(s). The facets are located at various axial positions, and at various angularly spaced rotational positions, such that, at differing rotational positions of the rotary device, at least one or none of the facets is positioned at the exterior opening.

Abstract: A method of treating skin including the application of a treatment gas to a surface of the skin and simultaneous neuro-muscular stimulation of the skin. The increased blood flow resulting from the neuro-muscular stimulation improves the effectiveness of the treatment gas. A medicine may be applied to the skin along with the treatment gas and the temperature of the treatment gas may be controlled to achieve a desired therapy. In one embodiment, a wound is treated by stimulating neuro-muscular activity near the wound while simultaneously applying an antibiotic and oxygen gas to the wound at a first warm temperature and then at a second cool temperature. The treatment gas applicator used to deliver the oxygen to the wound may further be used to provide repeatable measurements of the size of the wound over time. Other beneficial skin effects, such as hair growth and age retardation, may be achieved by applying specific treatment gases and medicines simultaneously with neuro-muscular stimulation.

Abstract: A tape cartridge which includes an internally disposed rotatable reel, wherein the tape cartridge includes two, three, or a plurality of piloting members disposed adjacent an annular ring to limit the movement of the reel within the tape cartridge. An automated data storage and retrieval system which includes a plurality of Applicants' tape cartridges. A method to prevent damage to a tape medium disposed in a tape cartridge.

Abstract: An absorbent garment having a pant-like configuration is constructed using side leak guards which are seamless, and which exhibit improved performance. The seamless leak guards are provided by incorporating a substantially liquid-impermeable outer cover into the garment having lateral edges which extend substantially beyond the lateral edges of the absorbent layer. Elastic bands attached to the outer cover urge the edges upward during wear, and against the wearer's body, to prevent leakage of waste material. The portions of the outer cover which extend laterally beyond the absorbent layer serve as seamless leak guards.

Abstract: A data storage cartridge having an data storage device, such as an encased magnetic disk drive assembly, is, in one embodiment, of generally an exterior dimensional form factor of a tape cartridge having a leader block with a hole therethrough for engagement by a threading pin. To distinguish the cartridge from a tape cartridge, the cartridge shell comprises a blocking portion at the location of the leader block hole. A transfer station both identifies the cartridge and indicates the presence of the cartridge at an end of travel in a cartridge receiver, employing an optical source and an opposed sensor directed toward the leader block hole when a cartridge is at the end of travel. In another embodiment, an encased magnetic disk drive assembly is supported and mounted in a cartridge shell by a shock mount.

Abstract: A tape cartridge which includes an internally disposed rotatable reel, wherein the tape cartridge includes two, three, or a plurality of piloting members disposed adjacent an annular ring to limit the movement of the reel within the tape cartridge. An automated data storage and retrieval system which includes a plurality of Applicants' tape cartridges. A method to prevent damage to a tape medium disposed in a tape cartridge.

Abstract: A device for blending materials comprising a carrier support (1) arranged to support a closed bag (3) containing a material to be blended, a kneading mechanism in the form of paddles (5) which are arranged to apply a kneading action to the bag walls for homogenizing its contents, and a clamping device (4) for holding the bag closed and against the carrier support (1) during kneading. The kneading mechanism (5) is arranged to act in conjunction with the carrier support (1) and an island baffle (7) to cause the contents of the bag to circulate during kneading.

Abstract: A wide area vehicle driving video game is discussed that includes remote activation of sounds that are communicated to other players across the wide area network. Also discussed is a naming feature that presents the names of players next to the car that they are driving. The name is presented in a font that can be read no matter how far away the car appears in the video game display.

Abstract: A wide area vehicle driving video game is discussed that includes remote activation of sounds that are communicated to other players across the wide area network. Also discussed is a naming feature that presents the names of players next to the car that they are driving. The name is presented in a font that can be read no matter how far away the car appears in the video game display.