Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A substantially constant pressure injection molding method and machine that forms molded parts by injecting molten thermoplastic material into a mold cavity at a substantially constant pressure. As a result, the mold cavity is filled with molten thermoplastic material by advancing a continuous flow front of thermoplastic material from a gate to an end of the mold cavity.

Abstract: A substantially constant pressure injection molding method and machine that forms molded parts by injecting molten thermoplastic material into a mold cavity at a substantially constant pressure. As a result, the mold cavity is filled with molten thermoplastic material by advancing a continuous flow front of thermoplastic material from a gate to an end of the mold cavity.

Abstract: A substantially constant pressure injection molding method and machine that forms molded parts by injecting molten thermoplastic material into a mold cavity at a substantially constant pressures. As a result, the mold cavity is filled with molten thermoplastic material by advancing a continuous flow front of thermoplastic material from a gate to an end of the mold cavity.

Abstract: A substantially constant pressure injection molding method and machine that forms molded parts by injecting molten thermoplastic material into a mold cavity at a substantially constant pressure. As a result, the mold cavity is filled with molten thermoplastic material by advancing a continuous flow front of thermoplastic material from a gate to an end of the mold cavity.

Abstract: A substantially constant pressure injection molding method and machine that forms molded parts by injecting molten thermoplastic material into a mold cavity at a substantially constant pressure. As a result, the mold cavity is filled with molten thermoplastic material by advancing a continuous flow front of thermoplastic material from a gate to an end of the mold cavity.

Abstract: A substantially constant pressure injection molding method and machine that forms molded parts by injecting molten thermoplastic material into a mold cavity at a substantially constant pressures. As a result, the mold cavity is filled with molten thermoplastic material by advancing a continuous flow front of thermoplastic material from a gate to an end of the mold cavity.

Abstract: The present invention relates to a portable device for spraying a liquid at low pressure, said device comprising a spray arm (220), and characterized in that the spray arm comprises at least one flat fan spray nozzle (230). Preferably, the liquid is a cleaning composition for treatment of carpets and other large fabric coverings, more preferably, a composition comprising surfactants. Also preferably, the portable device is electrically driven, and/or the spray arm is extendible and/or detachable from the device's main unit.

Abstract: The present invention is directed to a device for the delivery of products, preferably cleaning products which comprise an active ingredient and more preferably cleaning products which comprise a surfactant. The device includes at least one liquid reservoir for containing at least one product and a dispensing appliance for delivering the product. The dispensing appliance comprises at least one piercing means or at least one pierceable means, and the reservoir respectively comprises at least one corresponding pierceable means or at least one piercing means, such that the pierceable means recloses when the reservoir is removed from the dispensing appliance. Preferably, the piercing means is achieved by at least one needle.

Abstract: The invention is an extendible liquid-applying spray arm for use with a liquid source, such as an electrical sprayer. It includes one handle and at least two tubular members which are telescopingly engaged with and slideable along one another. Sliding the tubular members extends/retracts the spray arm respectively for treating/storage or to meet particular work needs which require that said extendible spray arm has a short length. When the spray arm is collapsed, the telescopic members are at least partially arranged within the handle, so that the global length of the spray arm is less than the additional lengths of the handle and the telescopic portion. The spray arm further comprises a spray member for spraying the liquid. A flexible tube extends around the tubular members and connects to the nozzle member, which is preferably coiled around the tubular members.

Abstract: The present invention is directed to a device comprising an appliance, and a reservoir suitable for being removably connected to said appliance, said appliance comprising at least one piercing means and said reservoir comprising one pierceable means, said appliance comprising a releasable protecting means for preventing access to said piercing means when said reservoir is not connected to said appliance. The present invention is further directed to said appliance, and also to said reservoir. In a preferred embodiment of the invention, the appliance comprises an actuation trigger to release said protecting means and give access to said piercing means, and said reservoir comprises a releasing means to cooperate with said actuation trigger in releasing said protecting means. Also preferably, said appliance and said reservoir are provided with cooperating securing means, so as to ensure that said reservoir is secured into said appliance, ones connected thereinto.

Abstract: The present invention relates to a packaged product (1) comprising a package having a liquid reservoir (2) for containing a product, preferably a cleaning product, and a means for delivering the product (4) in a labour efficient way and in a uniform manner. This is achieved by a packaged product (1) in which the means (4) for delivering the product preferably comprises an electrically driven pump (5), and further comprises a spray arm (220), the spray arm (220) having at least one dispensing opening (225). The spray arm (220) being preferably either extended or extendible.