Patents by Inventor John S. Condeelis

John S. Condeelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEOADJUVANT CHEMOTHERAPY INDUCES BREAST CANCER METASTASIS THROUGH A TMEM-MEDIATED MECHANISM
    Publication number: 20240019439
    Abstract: Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors. Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using inhibitors of Mena expression and/or function are also provided.
    Type: Application
    Filed: September 13, 2023
    Publication date: January 18, 2024
    Inventors: John S. Condeelis, Maja Oktay
  • HIGH RESOLUTION INTRAVITAL IMAGING AND USES THEREOF
    Publication number: 20240000391
    Abstract: Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.
    Type: Application
    Filed: June 21, 2023
    Publication date: January 4, 2024
    Inventors: David Entenberg, John S. Condeelis, Sonia E. Voiculescu
  • Method for treating neoadjuvant chemotherapy-induced metastasis
    Patent number: 11802875
    Abstract: Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors. Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using inhibitors of Mena expression and/or function are also provided.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: October 31, 2023
    Inventors: John S. Condeelis, Maja Oktay
  • High resolution intravital imaging and uses thereof
    Patent number: 11712205
    Abstract: Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: August 1, 2023
    Assignee: Albert Einstein College of Medicine
    Inventors: David Entenberg, John S. Condeelis, Sonia E. Voiculescu
  • METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20220251662
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Application
    Filed: September 16, 2021
    Publication date: August 11, 2022
    Applicants: Albert Einstein College of Medicine, Massachusetts Institute of Technology, IFO-Regina Elena Cancer Institute
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nistico
  • TMEM ACTIVE TEST AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20210223250
    Abstract: Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis.
    Type: Application
    Filed: March 23, 2021
    Publication date: July 22, 2021
    Inventors: John S. Condeelis, Allison S. Harney
  • METHOD FOR TREATING NEOADJUVANT CHEMOTHERAPY-INDUCED METASTASIS
    Publication number: 20210156861
    Abstract: Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors. Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using inhibitors of Mena expression and/or function are also provided.
    Type: Application
    Filed: May 30, 2018
    Publication date: May 27, 2021
    Inventors: John S. Condeelis, Maja Oktay
  • Methods involving Menain screening for inhibitors of cancer invasion and metastasis
    Patent number: 10928397
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: February 23, 2021
    Assignees: Massachusetts Institute of Technology, Albert Einstein College of Medicine
    Inventors: Frank B. Gertler, Shannon K. Hughes, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • COMBINED MARKERS FOR METASTATIC CANCER AND USES THEREOF
    Publication number: 20200393467
    Abstract: A combination of markers (TMEM, MenaCalc, and MenalNV) for hematogenous metastatic cancer and their use for diagnosis, prognosis and predictive performance are disclosed.
    Type: Application
    Filed: December 18, 2018
    Publication date: December 17, 2020
    Inventors: John S. Condeelis, Maja H. Oktay, Joan Jones, David Entenberg
  • HIGH RESOLUTION INTRAVITAL IMAGING AND USES THEREOF
    Publication number: 20200352516
    Abstract: Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 12, 2020
    Inventors: David Entenberg, John S. Condeelis, Sonia E. Voiculescu
  • MENAINV AND CANCER INVASION AND METASTASIS
    Publication number: 20190137501
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Application
    Filed: September 13, 2018
    Publication date: May 9, 2019
    Inventors: Frank B. Gertler, Shannon K. Hughes, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • Method of enhancing the efficacy of anti-hepatocyte growth factor receptor breast cancer therapy by administering an inhibitor of mena
    Patent number: 10114023
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: October 30, 2018
    Assignees: Massachusetts Institute of Technology, Albert Einstein College of Medicine, Inc.
    Inventors: Frank B. Gertler, Shannon K. Hughes-Alford, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • TMEM ACTIVE TEST AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20180106811
    Abstract: Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis.
    Type: Application
    Filed: May 24, 2016
    Publication date: April 19, 2018
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: John S. Condeelis, Allison S. Harney
  • Alternatively spliced mRNA isoforms as prognostic indicators for metastatic cancer
    Patent number: 9926601
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 27, 2018
    Assignees: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine, Inc.
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay
  • METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20170335406
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 23, 2017
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, IFO-REGINA ELENA CANCER INSTITUTE
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nistico
  • Metastasis specific splice variants of Mena and uses thereof in diagnosis, prognosis and treatment of tumors
    Patent number: 9719142
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: August 1, 2017
    Assignees: Albert Einstein College of Medicine, Inc., Massachusetts Institute of Technology, IFO-Regina Elena Cancer Institute
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nistico
  • MENAINV AND CANCER INVASION AND METASTASIS
    Publication number: 20150044234
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Application
    Filed: April 12, 2013
    Publication date: February 12, 2015
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Frank B. Gertler, Shannon K. Hughes-Alford, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER
    Publication number: 20140066319
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Application
    Filed: February 24, 2012
    Publication date: March 6, 2014
    Applicants: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay
  • METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20140057966
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Application
    Filed: November 7, 2013
    Publication date: February 27, 2014
    Applicants: Albert Einstein College of Medicine of Yeshiva University, IFO-Regina Elena Cancer Institute, Massachusetts Institute of Technology
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nistico
  • Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors
    Patent number: 8642277
    Abstract: Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: February 4, 2014
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Massachusetts Institute of Technology, Cornell University
    Inventors: John S. Condeelis, Thomas E. Rohan, Frank B. Gertler, Joan G. Jones