Patents by Inventor John S. Condeelis

John S. Condeelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MENAINV AND CANCER INVASION AND METASTASIS
    Publication number: 20150044234
    Abstract: Methods and compositions are provided for diagnosing or inhibiting invasion or metastasis of a cancer in a subject based on MenaINV.
    Type: Application
    Filed: April 12, 2013
    Publication date: February 12, 2015
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Frank B. Gertler, Shannon K. Hughes-Alford, Douglas A. Lauffenburger, Jason Neil, Forest White, John S. Condeelis, Madeleine J. Oudin
  • ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER
    Publication number: 20140066319
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Application
    Filed: February 24, 2012
    Publication date: March 6, 2014
    Applicants: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay
  • METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20140057966
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Application
    Filed: November 7, 2013
    Publication date: February 27, 2014
    Applicants: Albert Einstein College of Medicine of Yeshiva University, IFO-Regina Elena Cancer Institute, Massachusetts Institute of Technology
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nistico
  • Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors
    Patent number: 8642277
    Abstract: Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: February 4, 2014
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Massachusetts Institute of Technology, Cornell University
    Inventors: John S. Condeelis, Thomas E. Rohan, Frank B. Gertler, Joan G. Jones
  • Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors
    Patent number: 8603738
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: December 10, 2013
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Massachusetts Institute of Technology, IFO-Regina Elena Cancer Institute
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nisticò
  • DEVICE FOR COLLECTING AND ANALYZING MIGRATORY TUMOR CELLS
    Publication number: 20120322685
    Abstract: The present invention provides a method of isolating motile cells from an animal tissue, the method comprising implanting in the animal tissue a cell trap comprising a chamber with an inlet for ingress of motile cells and a porous matrix located in the chamber comprising a chemotactic factor, for a time sufficient for the motile cells to migrate into the cell trap; removing the implanted cell trap; and retrieving the motile cells from the cell trap.
    Type: Application
    Filed: January 14, 2011
    Publication date: December 20, 2012
    Inventors: John S. Condeelis, James Castracane
  • Isolation, gene expression, and chemotherapeutic resistance of motile cancer cells
    Patent number: 8298756
    Abstract: Methods of isolating motile cells of interest from an animal tissue is provided. Also provided are methods of determining mRNA or protein expression of a gene in motile cells of interest from an animal tissue. Additionally, methods of determining whether a cancer in a tissue of a mammal is likely to metastasize are provided. Methods are also provided for inhibiting metastasis of a cancer in a tissue of a mammal. Further provided are methods of determining resistance of a motile cancer cell population in an animal tissue to a chemotherapeutic agent.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: October 30, 2012
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventor: John S. Condeelis
  • Tumor Microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors
    Publication number: 20110059470
    Abstract: Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.
    Type: Application
    Filed: July 29, 2010
    Publication date: March 10, 2011
    Inventors: John S. Condeelis, Thomas E. Rohan, Frank B. Gertler, Joan G. Jones
  • Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors
    Publication number: 20100047240
    Abstract: Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
    Type: Application
    Filed: July 31, 2009
    Publication date: February 25, 2010
    Inventors: John S. Condeelis, Sumanta Goswami, Frank Gertler, Paola Nisticò
  • Isolation, Gene Expression, and Chemotherapeutic Resistance of Motile Cancer Cells
    Publication number: 20080138805
    Abstract: Methods of isolating motile cells of interest from an animal tissue is provided. Also provided are methods of determining mRNA or protein expression of a gene in motile cells of interest from an animal tissue. Additionally, methods of determining whether a cancer in a tissue of a mammal is likely to metastasize are provided. Methods are also provided for inhibiting metastasis of a cancer in a tissue of a mammal. Further provided are methods of determining resistance of a motile cancer cell population in an animal tissue to a chemotherapeutic agent.
    Type: Application
    Filed: August 4, 2005
    Publication date: June 12, 2008
    Inventor: John S. Condeelis