Patents by Inventor John S. O'Brien

John S. O'Brien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110306558
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Application
    Filed: February 7, 2011
    Publication date: December 15, 2011
    Applicant: MYELOS CORPORATION
    Inventors: John S. O'BRIEN, Yasuo KISHIMOTO
  • Publication number: 20110195908
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Application
    Filed: April 13, 2011
    Publication date: August 11, 2011
    Applicant: Myelos Corporation
    Inventors: John S. O'Brien, Yasuo Kishimoto
  • Publication number: 20100260734
    Abstract: A method for stimulating prosaposin receptor activity in a cell by transfecting the cell with a DNA or RNA molecule encoding prosaposin or a prosaposin receptor agonist. The DNA or RNA molecule is administered either in vivo or used to transfect neural cells or neural stem cells ex vivo followed by reintroduction of the cells into an individual.
    Type: Application
    Filed: April 15, 2010
    Publication date: October 14, 2010
    Applicant: MYELOS CORPORATION
    Inventors: John S. O'BRIEN, D. Elliot PARKS
  • Patent number: 7524818
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: April 28, 2009
    Assignee: Myelos Corporation
    Inventors: John S. O'Brien, Yasuo Kishimoto
  • Publication number: 20090087476
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Application
    Filed: June 18, 2003
    Publication date: April 2, 2009
    Inventors: John S. O'Brien, Yasuo Kishimoto
  • Publication number: 20080287354
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Application
    Filed: April 16, 2007
    Publication date: November 20, 2008
    Inventors: John S. O'Brien, Yasuo Kishimoto
  • Patent number: 7259481
    Abstract: An automatic transfer switch (ATS) system and method of operating an ATS system are disclosed. The ATS system includes at least one input port capable of being coupled to at least one power source to receive an input power, a first internal component that requires internal power satisfying a first criterion in order to properly operate, and a power converter such as a switch mode power supply that is coupled to the first internal component and to the at least one input port. The power converter is capable of receiving the input power by way of the at least one input port and converting the input power into the internal power to be provided to the first internal component. The internal power provided by the power converter satisfies the first criterion, even though at least one characteristic of the input power varies within a range.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: August 21, 2007
    Assignee: Kohler Co.
    Inventors: Zane C. Eaton, John S. O'Grady
  • Patent number: 7194032
    Abstract: A video processing circuit includes a processor that receives an encoded image having first and second regions, decodes the first region of the image, modifies the decoded first region, and re-encodes the modified first region. Such a circuit allows one to modify a region of an image by decoding and re-encoding only that region instead of the entire image. For example, if one wishes to overlay an EPG on a bottom portion of a video frame, then the circuit can decode only the EPG and the bottom portion of the frame, overlay the decoded EPG on the bottom frame portion, and re-encode the overlaid bottom frame portion. Therefore, this technique often reduces the processing time, and thus the cost and complexity of the processing circuit, as compared to a circuit that decodes and re-encode the entire frame during an image overlay process.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: March 20, 2007
    Assignee: Equator Technologies, Inc.
    Inventors: Venkat V. Easwar, John S. O'Donnell, Ramachandran Natarajan, Robert J. Grove
  • Patent number: 6964367
    Abstract: A method and apparatus for automatically acquiring and verifying, relative to pre-established rules, information affixed to relatively flat articles transported along a transport path comprises a weighing device for measuring weight of articles being processed, an image acquisition device for acquiring a representation of indicia appearing on an article, a thickness detecting device for measuring the thickness of articles being processed, a processing device for recognition of the indicia appearing on an article, and a processing device for verifying acquired data against the pre-established rules. A number of reports are generated after processing to provide the results of the processing.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: November 15, 2005
    Assignee: Bowe Bell + Howell Company
    Inventors: John S. O'Callaghan, Daniel Gibbons, Tony S. Chan, Ann Dawkins, Niren Shah, Jack Bonn
  • Patent number: 6849602
    Abstract: The invention provides a method of alleviating neuropathic pain in a subject by administering a neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The invention also provides a method of inhibiting the onset of neuropathic pain in a subject by administering neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The present invention also provides prosaposin receptor agonists and the use of these agonists for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting neural demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective inhibiting amount of prosaposin receptor agonist.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: February 1, 2005
    Assignee: The Regents of the University of California
    Inventor: John S. O'Brien
  • Publication number: 20040233602
    Abstract: An automatic transfer switch (ATS) system and method of operating an ATS system are disclosed. The ATS system includes at least one input port capable of being coupled to at least one power source to receive an input power, a first internal component that requires internal power satisfying a first criterion in order to properly operate, and a power converter such as a switch mode power supply that is coupled to the first internal component and to the at least one input port. The power converter is capable of receiving the input power by way of the at least one input port and converting the input power into the internal power to be provided to the first internal component. The internal power provided by the power converter satisfies the first criterion, even though at least one characteristic of the input power varies within a range.
    Type: Application
    Filed: February 27, 2004
    Publication date: November 25, 2004
    Inventors: Zane C. Eaton, John S. O'Grady
  • Publication number: 20040211838
    Abstract: A method and apparatus for automatically acquiring and verifying, relative to pre-established rules, information affixed to relatively flat articles transported along a transport path comprises weighing means for measuring weight of articles being processed, image acquisition means for acquiring a representation of indicia appearing on an article, thickness detecting means for measuring the thickness of articles being processed, processing means for recognition of the indicia appearing on an article, and processing means for verifying acquired data against the pre-established rules. A number of reports are generated after processing to provide the results of the processing.
    Type: Application
    Filed: September 7, 2001
    Publication date: October 28, 2004
    Inventors: John S. O'Callaghan, Daniel Gibbons, Tony S. Chan, Ann Dawkins, Niren Shah, Jack Bonn
  • Publication number: 20040121958
    Abstract: The invention provides a method of alleviating neuropathic pain in a subject by administering a neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The invention also provides a method of inhibiting the onset of neuropathic pain in a subject by administering neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The present invention also provides prosaposin receptor agonists and the use of these agonists for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting neural demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective inhibiting amount of prosaposin receptor agonist.
    Type: Application
    Filed: December 24, 2003
    Publication date: June 24, 2004
    Applicant: The Regents of the University of California, a California corporation
    Inventor: John S. O'Brien
  • Patent number: 6590074
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: July 8, 2003
    Assignee: Myelos Corporation
    Inventors: John S. O'Brien, Yasuo Kishimoto
  • Patent number: 6575358
    Abstract: Apparatus for automatically acquiring and verifying, relative to pre-established rules, information affixed to relatively flat articles transported along a transport path comprises weighing component device for measuring weight of articles being processed, image acquisition device for acquiring a representation of indicia appearing on an article, processing device for recognition of the indicia appearing on an article, and processing device for verifying acquired data against the pre-established rules.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: June 10, 2003
    Assignee: Bell & Howell Postal Systems Inc.
    Inventors: John S. O'Callaghan, Daniel Gibbons, Tony S. Chan, Ann Dawkins, Niren Shah, Jack Bonn
  • Publication number: 20030096786
    Abstract: A method for stimulating prosaposin receptor activity in a cell by transfecting the cell with a DNA or RNA molecule encoding prosaposin or a prosaposin receptor agonist. The DNA or RNA molecule is administered either in vivo or used to transfect neural cells or neural stem cells ex vivo followed by reintroduction of the cells into an individual.
    Type: Application
    Filed: November 13, 2002
    Publication date: May 22, 2003
    Inventors: John S. O'Brien, D. Elliot Parks, Susan L. O'Brien
  • Patent number: 6559124
    Abstract: Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination ex vivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: May 6, 2003
    Assignee: Myelos Corporation
    Inventors: John S. O'Brien, Yasuo Kishimoto
  • Patent number: 6498816
    Abstract: A video processing circuit includes a processor that receives encoded images each having respective first and second regions and that receives a motion vector of the first region of a first one of the images. If the motion vector points to the second region of an image, the processor re-encodes at least a portion of the first region of the first image such that the first region of the first image has no motion vector that points to the second region of an image.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: December 24, 2002
    Assignee: Equator Technologies, Inc.
    Inventors: Venkat V. Easwar, John S. O'Donnell, Ramachandran Natarajan, Robert J. Gove
  • Patent number: 6458357
    Abstract: Retro-inverso peptide analogs derived from the active neurotrophic region of saposin C. The saposin C-derived peptides (prosaptides) induce neurite outgrowth in vitro, prevent programmed cell death, induce myelination and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and pain management. The retro-inverso peptides are significantly more resistant to metabolic degradation than the corresponding non-inverted peptides.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: October 1, 2002
    Assignee: Myelos Corporation
    Inventors: Michael T. White, John S. O'Brien, David E. Wright
  • Publication number: 20020128193
    Abstract: Retro-inverso peptide analogs derived from the active neurotrophic region of saposin C which include the amino acid sequence LLEENNDL (all D-amino acids) (SEQ ID NO: 4). These peptides induce neurite outgrowth in vitro, prevent programmed cell death, induce myelination and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and neuropathic pain.
    Type: Application
    Filed: September 19, 2001
    Publication date: September 12, 2002
    Inventors: John S. O'Brien, David E. Wright, Susan L. O'Brien