Abstract: A computer-implemented method for training an artificial intelligence based neural network is provided. At least one digital image of at least one security document is provided as a reference. A set of digital training images is provided, wherein these are altered compared to the digital image of the security document. The set of digital training images includes a first subset of positive digital training images having a visual impact of an alteration such that an unbiased human observer would consider a reproduction of the respective digital training image to represent the security document or multiple security documents. The set of digital training images includes a second subset of negative digital training images. Ground truth is provided to the neural network as to whether a reproduction of the respective digital training image is to be considered representing the security document or multiple security documents or not.

Abstract: An apparatus for the production of nanoparticles is provided. The apparatus includes a main tube that is closed at a bottom, an inlet channel arranged within the main tube and includes a first opening to the outside of the apparatus and a second opening to the main tube, and a main opening in the main tube. The main tube includes a sample position at the bottom, the cross section of the main tube at the sample position is smaller than at other positions of the main tube, and the second opening of the inlet channel is arranged closer to the sample position than the main opening. Furthermore, an arrangement for the production of nanoparticles and a method for producing nanoparticles are provided.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: A system for repairing a glenoid defect of a specific patient can include a patient-specific punch and a patient-specific shaping block. The patient-specific punch can form a patient-specific glenoid implant from a bone puck. The patient-specific shaping block can shape the patient-specific glenoid implant to match and fill a glenoid defect of a specific patient.

Abstract: A system for repairing a glenoid defect of a specific patient can include a patient-specific punch and a patient-specific shaping block. The patient-specific punch can form a patient-specific glenoid implant from a bone puck. The patient-specific shaping block can shape the patient-specific glenoid implant to match and fill a glenoid defect of a specific patient.

Abstract: A system for repairing a glenoid defect of a specific patient can include a patient-specific punch and a patient-specific shaping block. The patient-specific punch can form a patient-specific glenoid implant from a bone puck. The patient-specific shaping block can shape the patient-specific glenoid implant to match and fill a glenoid defect of a specific patient.

Abstract: A system for repairing a glenoid defect of a specific patient can include a patient-specific punch and a patient-specific shaping block. The patient-specific punch can form a patient-specific glenoid implant from a bone puck. The patient-specific shaping block can shape the patient-specific glenoid implant to match and fill a glenoid defect of a specific patient.

Abstract: A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support.

Abstract: A position lock for a steering column comprises a rake lock bracket, a tooth lock and a driver. The rake lock bracket is fixed to the vehicle has a rake lock tooth wall that bounds a control slot and that defines a plurality of rake lock teeth. The tooth lock is coupled to the steering column for movement in a raking direction and supported for rotation about a tooth lock rotation axis. The driver, supported for translation with the tooth lock and for rotation about a driver rotation axis, is configured for contacting an actuation feature of the tooth lock so as to cause the tooth lock to rotate with the driver as the driver rotates within the active range of rotation of the driver.

Abstract: A position lock for a steering column comprises a rake lock bracket, a tooth lock and a driver. The rake lock bracket is fixed to the vehicle has a rake lock tooth wall that bounds a control slot and that defines a plurality of rake lock teeth. The tooth lock is coupled to the steering column for movement in a raking direction and supported for rotation about a tooth lock rotation axis. The driver, supported for translation with the tooth lock and for rotation about a driver rotation axis, is configured for contacting an actuation feature of the tooth lock so as to cause the tooth lock to rotate with the driver as the driver rotates within the active range of rotation of the driver.

Abstract: A locking device for a steering column and method of installing the locking device are provided. The locking device includes a spring body configured for installation on a rotatable bolt and comprising a biasing portion. The spring body is rotatable in one direction through a first range and second range. A lock body includes a body portion configured for mounting on the rotatable bolt and a locking portion configured to move between a first position and a second position. The biasing portion of the spring body contacts the lock body and causes the lock body to rotate with the spring body through the first range. The spring body is rotatable relative to the lock body through the second range such that at least a portion of the biasing portion is elastically deflected when the spring body is rotated through the second range.

Abstract: A position lock for a steering column comprises a rake lock bracket, a tooth lock, a driver, and a spring. The rake lock bracket is fixed to the vehicle has a rake lock tooth wall that bounds a control slot and that defines a plurality of rake lock teeth. The tooth lock is coupled to the steering column for movement in a raking direction and supported for rotation about a tooth lock rotation axis. The driver, supported for translation with the tooth lock and for rotation about a driver rotation axis, is configured for contacting an actuation feature of the tooth lock so as to cause the tooth lock to rotate with the driver as the driver rotates within the active range of rotation of the driver. The spring is configured and arranged to apply a biasing moment to cause the tooth lock to rotate in a locking direction.

Abstract: An adjustment assembly for allowing or preventing adjustment of a component and an adjustable steering column are provided. A compression bracket is configured to support the steering column, a rake bracket is configured to support the compression bracket and an actuating lever is slidingly coupled to the compression bracket and slidable along a linear travel path. A linkage assembly is connected to the compression bracket and is coupled to one end of the actuating lever and a clamping assembly is coupled to the linkage assembly and configured to release a clamping force from the component upon movement of the actuating lever from a first position to a second position, and apply a clamping force to the component upon movement of the actuating lever from the second position to the first position.

Abstract: A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support.

Abstract: A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support.

Abstract: An adjustment assembly and adjustable steering column including a linearly slidable actuating lever are provided. The actuating lever is slidable between a first position and a second position along a linear travel path. The actuating lever includes an engaging portion which engages a gear assembly. The gear assembly is connected to a clamping mechanism. The clamping mechanism is configured to apply or release a clamping force on a steering column or other component. Movement of the actuating lever between the first and second positions causes rotation of the gear assembly. Rotation of the gear assembly causes the clamping mechanism to apply or release the clamping force, depending on the direction of rotation. The adjustment assembly also includes a rake bracket to support a compression bracket. The compression bracket supports the component or steering column.

Abstract: A position lock for a steering column comprises a rake lock bracket, a tooth lock, a driver, and a spring. The rake lock bracket is fixed to the vehicle has a rake lock tooth wall that bounds a control slot and that defines a plurality of rake lock teeth. The tooth lock is coupled to the steering column for movement in a raking direction and supported for rotation about a tooth lock rotation axis. The driver, supported for translation with the tooth lock and for rotation about a driver rotation axis, is configured for contacting an actuation feature of the tooth lock so as to cause the tooth lock to rotate with the driver as the driver rotates within the active range of rotation of the driver. The spring is configured and arranged to apply a biasing moment to cause the tooth lock to rotate in a locking direction.

Abstract: A locking device for a steering column and method of installing the locking device are provided. The locking device includes a spring body configured for installation on a rotatable bolt and comprising a biasing portion. The spring body is rotatable in one direction through a first range and second range. A lock body includes a body portion configured for mounting on the rotatable bolt and a locking portion configured to move between a first position and a second position. The biasing portion of the spring body contacts the lock body and causes the lock body to rotate with the spring body through the first range. The spring body is rotatable relative to the lock body through the second range such that at least a portion of the biasing portion is elastically deflected when the spring body is rotated through the second range.

Abstract: An adjustment assembly for allowing or preventing adjustment of a component and an adjustable steering column are provided. A compression bracket is configured to support the steering column, a rake bracket is configured to support the compression bracket and an actuating lever is slidingly coupled to the compression bracket and slidable along a linear travel path. A linkage assembly is connected to the compression bracket and is coupled to one end of the actuating lever and a clamping assembly is coupled to the linkage assembly and configured to release a clamping force from the component upon movement of the actuating lever from a first position to a second position, and apply a clamping force to the component upon movement of the actuating lever from the second position to the first position.

Abstract: An adjustment assembly and adjustable steering column including a linearly slidable actuating lever are provided. The actuating lever is slidable between a first position and a second position along a linear travel path. The actuating lever includes an engaging portion which engages a gear assembly. The gear assembly is connected to a clamping mechanism. The clamping mechanism is configured to apply or release a clamping force on a steering column or other component. Movement of the actuating lever between the first and second positions causes rotation of the gear assembly. Rotation of the gear assembly causes the clamping mechanism to apply or release the clamping force, depending on the direction of rotation. The adjustment assembly also includes a rake bracket to support a compression bracket.