Abstract: The invention includes a steering column assembly positionable in a vehicle. The invention also includes a connecting device releaseably attachable to the vehicle. The connecting device is moveable between a locked configuration and an unlocked configuration to selectively lock the steering column assembly with respect to the vehicle. The invention also includes a first energy absorber disposed between the connecting device and the steering column assembly. The first energy absorber is selectively engageable to dissipate energy. For example, the first energy absorber is engaged to dissipate energy in response to relative movement between the connecting device and the steering column assembly when the connecting device is in the locked configuration. The first energy absorber is disengaged with respect to dissipating energy in response to relative movement between the connecting device and the steering column assembly when the connecting device is in the unlocked configuration.

Abstract: The present invention provides an apparatus for supporting a steering wheel in a vehicle during normal vehicle handling and is breakable in response to an impact situation. The apparatus includes a member attachable to a vehicle and a steering column connected to the member for sliding movement. The apparatus also includes a capsule for connecting the member and the steering column to one another to prevent the sliding movement during normal vehicle handling. The capsule maintains the member and the steering column relative to one another, overcoming forces urging movement between the member and the steering column relative to one another, up to a first predetermined level of force. When the forces reach the first predetermined level, such as in an impact situation, the capsule breaks and releases the member and the steering column relative to one another.

Abstract: Compounds of formulae (IA) and (IB): wherein R1, R2, R3, Ar1 and X are as defined above, are endothelin antagonists. The compounds are therefore useful in the treatment of a variety of conditions mediated by endothelin, such as restenosis, renal failure and systemic and pulmonary hypertension.

Abstract: Compounds of formula (I), pharmaceutical formulations thereof and the use of such compounds for treating endothelin mediated diseases or conditions are described herein. The compounds of the present invention have affinity for endothelin receptors, are selective for ETA over ETB, and thus are useful in the treatment of conditions mediated by endothelin.

Abstract: Compounds of formulae (IA) and (IB): 1

Abstract: Compounds of formulae (IA) and (IB): wherein R1, R2, R3, Ar1 and X are as defined above, are endothelin antagonists. The compounds are therefore useful in the treatment of a variety of conditions mediated by endothelin, such as restenosis, renal failure and systemic and pulmonary hypertension.

Abstract: Compounds of formula (I), pharmaceutical formulations thereof and the use of such compounds for treating endothelin mediated diseases or conditions are described herein.

Abstract: Isoxazole-sulfonamide endothelin antagonists of formula (I) below having good affinity for endothelin receptors and selectivity for ETA over ETB are described herein. Such compounds are useful in the treatment of conditions mediated by endothelin, in particular, conditions mediated by endothelin ETA.

Abstract: Isoxazole-sulfonamide endothelin antagonists of formula (I) below having good affinity for endothelin receptors and selectivity for ETA over ETB are described herein.

Abstract: The invention provides an insect- or acarid-repellent formulation comprising a compound of formula (I), wherein R represents straight or branched chain C.sub.2-10 alkyl, straight or branched chain C.sub.2-10 alkenyl, or straight or branched chain C.sub.2-10 alkynyl, which groups are optionally substituted by one or more groups selected from halogen, C.sub.4-8 cycloalkyl and C.sub.4-8 cycloalkenyl; and a suitable adjuvant, diluent or carrier.

Abstract: A disc drive has a recording disc rotatable about an axis and a slider supporting a transducing head for transducing data with the disc. A dual-stage actuation assembly supports the slider to position the transducing head adjacent a selected radial track of the disc, and includes a movable actuator arm and a load beam connected to the actuator arm. A flexure is connected to the load beam for supporting the slider, and includes first conductive traces terminating at first bond pads and at least one second conductive trace electrically connected to the transducing head. A microactuator includes a rotor operatively connected to the slider for radially moving the transducing head and a stator connected to the flexure at the first bond pads.

Abstract: This invention relates to hexahydroindolizinones, which are useful as inhibitors of cardiac arrhythmias and of platelet aggregation and are therefore useful in the treatment of irregular heartbeat and in the prevention of thrombus formation.

Abstract: Preparation of 21-(acetyloxy)-3-oxo-24-norchola-4,20(22)-diene-23-nitrile; its diuretic, antiulcerogenic, and antiviral utility; and intermediates whereby the preparation can be variously effected are disclosed.