Abstract: The invention relates to new substituted heteroaryls of formula 1 wherein A is selected from the group consisting of N and CH D is selected from the group consisting of CH, N, NH, S and O, E is selected from the group consisting of C and N, T is selected from the group consisting of C and N, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.

Abstract: The present disclosure generally provides for advanced single camera video conferencing systems, and methods related thereto. The advanced single camera video conferencing system features a hybrid optical/digital camera, herein a camera device, having a controller that is configured to execute one or more of the methods set forth herein. In one embodiment, a method includes optically framing, a first portion of a video conferencing environment to provide an actual field-of-view, digitally framing a second portion of the video conferencing environment to provide an apparent field-of-view that is encompassed within the actual field-of-view, generating a video stream of the apparent field-of-view, surveying the actual field-of-view to generate survey data, and detecting changes in the survey data over time. The method may be performed using a single camera device using a single image sensor.

Abstract: Disclosed herein are various rotary cutting tools in which each have a plurality of blades disposed on an outer surface of the cutting tool. Disclosed also are a variety of systems or apparatuses for maintaining or cutting rubber surfaces into which one or more of the cutting tools can be incorporated.

Abstract: A blow mold clamping apparatus and a blow molding system are disclosed.

Abstract: Pharmaceutical ophthalmic compositions are described, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial agent (such as moxifloxacin), a therapeutically effective quantity of an anti-inflammatory agent (such as prednisolone), a combination of at least two solubilizing and suspending agents (of which one is a non-ionic polyoxyethlene-polyoxypropylene block copolymer), and a carrier. Methods for fabricating the compositions and using them are also described.

Abstract: Pharmaceutical compositions for intraocular injection are described, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial agent (such as moxifloxacin), a therapeutically effective quantity of an anti-inflammatory agent (such as triamcinolone), at least one pharmaceutically acceptable excipient and a pharmaceutically acceptable carrier. Methods for fabricating the compositions and using them for intraocular injections are also described.

Abstract: A waste heat recovery (WHR) and coolant system with active coolant pressure control includes an engine cooling system, a WHR system, and a coolant pressure control system. A coolant heat exchanger positioned along each of the engine cooling and working fluid circuits, and is structured to transfer heat from the coolant fluid to the working fluid. The coolant pressure control system includes a pressure line operatively coupled to an air brake system and to the coolant tank. A valve is coupled to the pressure line upstream of the coolant tank. A coolant pressure controller is in operative communication with each of the valve, an air pressure sensor, and a coolant temperature sensor. The coolant pressure controller is structured to determine a target coolant pressure based on a coolant temperature and control a valve position of the valve so as to cause the air pressure to approach the target coolant pressure.

Abstract: Harvested stem cells are activated by treating them with an amplitude modulated laser beam having a wavelength lying in the range of 405 to 980 nanometers. The frequency of the laser beam is modulated within a range of 8 to 12 MHz. Using the activated stem cells, tissue can be repaired and regenerated by preparing the unactivated stem cells, treating the unactivated stem cells with an amplitude modulated laser beam having a pre-determined frequency for obtaining activated stem cells, administering the activated stem cells into a body containing the tissue, and using a homing beam to guide the activated stem cells within the body to the location of the tissue.

Abstract: The present disclosure generally provides for advanced single camera video conferencing systems, and methods related thereto. The advanced single camera video conferencing system features a hybrid optical/digital camera, herein a camera device, having a controller that is configured to execute one or more of the methods set forth herein. In one embodiment, a method includes optically framing, a first portion of a video conferencing environment to provide an actual field-of-view, digitally framing a second portion of the video conferencing environment to provide an apparent field-of-view that is encompassed within the actual field-of-view, generating a video stream of the apparent field-of-view, surveying the actual field-of-view to generate survey data, and detecting changes in the survey data over time. The method may be performed using a single camera device using a single image sensor.

Abstract: A robotic surgical system includes a robotic manipulator that includes a mounting fixture defining a longitudinal channel, and a surgical tool removably coupleable to the mounting fixture. The surgical tool including a tool housing matable with the mounting fixture, an elongate shaft extending from the tool housing and receivable within the channel, and a latching mechanism provided on the elongate shaft and comprising one or more retention tabs biased radially outward with one or more biasing members. The one or more retention tabs are movable between a deployed state, where the one or more retention tabs protrude radially outward through a corresponding one or more slots to engage the mounting fixture, and a retracted state, where the one or more retention tabs are urged radially inward through the one or more slots to disengage the mounting fixture.

Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.

Abstract: Disclosed herein are various rotary cutting tools in which each have a plurality of blades disposed on an outer surface of the cutting tool. Disclosed also are a variety of systems or apparatuses for maintaining or cutting rubber surfaces into which one or more of the cutting tools can be incorporated.

Abstract: A genomic data translation system can be configured to process next-generation sequencing information. The system can receive an output file including raw genome data. The system can parse the output file to determine segments corresponding to individual chromosomes. The system can identify ranges of nucleotides and determine the first set of genes included in a human reference genome listing that fall within the ranges. The system can also maintain a gene list of genes, and determine a matched set of genes that are included in the gene list and the first set of genes. The system can generate a configurable text string including non-configurable regions and configurable regions. The configurable regions can be populated with text based on the raw genomic data, a set of translation rules, and a set of translation text strings.

Abstract: One embodiment provides a method, comprising: detecting, using a processor, a notification at an information handling device; detecting, using a processor, availability of an input associated with an user at the information handling device; and selecting, using a processor, an operating mode of the information handling device, wherein the selected operating mode of the information handling device comprises a mode that modulates a noise. Other aspects are described and claimed.

Abstract: Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

Abstract: Sliding fenestration systems that compensate for changes in opening height after installation and methods of installing such sliding fenestration systems are described herein. The head track of a sliding fenestration system moves vertically relative to the bottom of the building opening to compensate for changes in building opening height while still maintaining lateral support for the panels in the sliding fenestration system by virtue of a direct connection between the head track and the top of the building opening.

Abstract: A head-mounted display system is provided, including a head-mounted display, an imaging sensor, and a processor. The processor may convey instructions to the head-mounted display to display a virtual object at a world-locked location in a physical environment. The processor may receive imaging data of the physical environment from the imaging sensor. The processor may determine, based on the imaging data, that a world-space distance between a hand of a user and the world-locked location is below a predetermined distance threshold. The processor may convey instructions to the head-mounted display to display a bounding virtual object that covers at least a portion of the virtual object. The processor may detect, based on the imaging data, a change in the world-space distance. The processor may convey instructions to the head-mounted display to modify a visual appearance of the bounding virtual object based on the change in the world-space distance.

Abstract: A secure element device for use in a connected device includes a first interface configured to enable communication with a communication module and a second interface configured to enable communication with an action module of the connected device. A processor coupled to the first interface and the second interface, executes a first set of computer-readable instructions, stored in a memory of the secure element device, to authenticate, via the first interface, the connected device on the communication network. The processor also executes a second set of computer-readable instructions, stored in the memory, to perform one or both of (i) obtaining, via the second interface, data from the action module, the data to be transmitted over the communication network and (ii) controlling, via the second interface, the action module to cause the action module to perform one or more operations based on an instruction received over the communication network.

Abstract: The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as “APC target”) or a target on a T-cell (also referred to herein as “T-cell target”). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.

Abstract: The invention relates to catalytic aromatization, e.g., for the conversion of non-aromatic hydrocarbon to higher-value aromatic hydrocarbon, to catalysts useful for such aromatization, to methods for making such catalysts, and to systems and apparatus for carrying out aromatization in the presence of the catalyst.