Patents by Inventor John T. Groves

John T. Groves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220288021
    Abstract: A method and compositions of matter for treating or preventing an auto-immune disorder or immune response in a patient, that includes providing a therapeutic dose to the patient of a substituted indole compound having at least one substitution, wherein the substituted indole compound has only one thiol group, and wherein the ring the thiol group is attached to only contains one N or O atom.
    Type: Application
    Filed: July 10, 2020
    Publication date: September 15, 2022
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Micah T. Nelp
  • Publication number: 20220185748
    Abstract: In one aspect, the disclosure relates to a method for functionalizing hydrocarbons. In a further aspect, the method involves heating a hydrocarbon with a composition having an acid and an oxidant. In other aspects, the composition can further include an iodine-based compound and/or a compound having formula AaXn. In any of these aspects, the oxidant can be regenerated in situ or in a separate regeneration step. Also disclosed are functionalized hydrocarbons produced by the disclosed method. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: March 13, 2020
    Publication date: June 16, 2022
    Inventors: Thomas B. GUNNOE, John T. GROVES, William A. GODDARD, III
  • Publication number: 20220098037
    Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
    Type: Application
    Filed: December 14, 2021
    Publication date: March 31, 2022
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: John T. Groves, Roy Xiao
  • Patent number: 11242248
    Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: February 8, 2022
    Assignee: The Trustees of Princeton University
    Inventors: John T. Groves, Roy Xiao
  • Patent number: 10974235
    Abstract: Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: April 13, 2021
    Assignee: TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: John T. Groves, Xiongyi Huang
  • Publication number: 20200190012
    Abstract: Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.
    Type: Application
    Filed: February 26, 2020
    Publication date: June 18, 2020
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Wei Liu, Xiongyi Huang
  • Publication number: 20200108380
    Abstract: Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
    Type: Application
    Filed: December 3, 2019
    Publication date: April 9, 2020
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Xiongyi Huang
  • Patent number: 10590057
    Abstract: Methods of C—H bond fluorination using non-heme manganese catalyst are described herein. For example, a method comprises providing a reaction mixture including a non-heme manganese catalyst, a substrate comprising an sp3 C—H bond and a fluorinating agent and converting the sp3 C—H bond to a C—F bond in the presence of the non-heme manganese catalyst or a derivative thereof.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: March 17, 2020
    Assignee: The Trustees of Princeton University
    Inventors: John T. Groves, Xinyi Chen
  • Patent number: 10543481
    Abstract: Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: January 28, 2020
    Assignee: TRUSTEES OF PRINCETON UNIVESITY
    Inventors: John T. Groves, Xiongyi Huang
  • Patent number: 10450259
    Abstract: Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like. Systems and methods as described herein can utilize photocatalysis.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: October 22, 2019
    Assignees: University of Virginia Patent Foundation, The Trustees of Princeton University
    Inventors: Thomas Brent Gunnoe, George Fortman, Nicholas C. Boaz, John T. Groves
  • Patent number: 10414651
    Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: September 17, 2019
    Assignee: The Trustees of Princeton University
    Inventors: John T. Groves, Roy Xiao
  • Publication number: 20190256355
    Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
    Type: Application
    Filed: May 1, 2019
    Publication date: August 22, 2019
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Roy Xiao
  • Publication number: 20190127311
    Abstract: Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Applicant: The Trustees Of Princeton University
    Inventors: John T. Groves, Wei Liu
  • Publication number: 20190062255
    Abstract: Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like. Systems and methods as described herein can utilize photocatalysis.
    Type: Application
    Filed: August 31, 2018
    Publication date: February 28, 2019
    Inventors: Thomas Brent Gunnoe, George Fortman, Nicholas C. Boaz, John T. Groves
  • Patent number: 10196341
    Abstract: Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: February 5, 2019
    Assignee: The Trustees Of Princeton University
    Inventors: John T. Groves, Wei Liu
  • Publication number: 20180362432
    Abstract: Methods of C—H bond fluorination using non-heme manganese catalyst are described herein. For example, a method comprises providing a reaction mixture including a non-heme manganese catalyst, a substrate comprising an sp3 C—H bond and a fluorinating agent and converting the sp3 C—H bond to a C—F bond in the presence of the non-heme manganese catalyst or a derivative thereof.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 20, 2018
    Inventors: John T. GROVES, Xinyi CHEN
  • Publication number: 20180037526
    Abstract: Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
    Type: Application
    Filed: February 9, 2016
    Publication date: February 8, 2018
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Xiongyi Huang
  • Publication number: 20170305769
    Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of a manganese porphyrin catalyst or a manganese porphyrazine catalyst are described. Methods, kits, cartridges, and compounds related to decomposed cyanide ions and hydrogen cyanide for water decontamination.
    Type: Application
    Filed: July 7, 2017
    Publication date: October 26, 2017
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Thomas P. Umile
  • Patent number: 9708665
    Abstract: A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: July 18, 2017
    Assignee: The Regents of the University of California
    Inventors: Khalid S. Salaita, Pradeep M. Nair, Joe W. Gray, John T. Groves
  • Patent number: 9701557
    Abstract: Methods, kits, cartridges and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of a manganese porphyrin catalyst or a manganese porphyrazine catalyst are described. Methods, kits, cartridges and compounds related to decomposed cyanide ions and hydrogen cyanide for water decontamination.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: July 11, 2017
    Assignee: The Trustees of Princeton University
    Inventors: John T. Groves, Thomas P. Umile