Patents by Inventor John Thomas Sime

John Thomas Sime has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Flavor/aroma materials and their preparation
    Patent number: 6844019
    Abstract: Flavor components, particularly for a vanilla composition, are produced by essentially natural methods employing biotransformation of plant-derived materials. Ferulic acid, a component of many plant cell walls, may be converted into vanillin, directly or indirectly. A plurality of such compounds may undergo bioconversions to produce components of a flavor composition.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: January 18, 2005
    Assignee: Zylepsis Limited
    Inventors: Peter Samuel James Cheetham, Michelle Lorraine Gradley, John Thomas Sime
  • Use of sesquiterpenes for inhibiting oxidative enzymes
    Patent number: 6054490
    Abstract: The invention relates to the use of a sesquiterpene for inhibiting an oxidative enzyme, preferably a cytochrome P450 enzyme. The invention also relates to compositions comprising a sesquiterpene and a drug which exhibits instability in the presence of an oxidative enzyme.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: April 25, 2000
    Assignee: Zylepsis Limited
    Inventors: John Thomas Sime, Peter Samuel James Cheetham, Michelle Lorraine Gradley, Nigel Eric Banister
  • Heterocyclic compounds as pharmaceutical
    Patent number: 6048883
    Abstract: This invention provides compounds of formula (I):A.sup.1 --X--(CH.sub.2).sub.n --O--A.sup.2 --A.sup.3 --Y.R.sup.2(I)or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein A.sup.1, A.sup.2, A.sup.3, R.sup.2, X, Y and n are as defined herein; pharmaceutical composition comprising such compounds and the use of such a compounds for treating hyperglycemia.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: April 11, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Haigh, John Thomas Sime
  • Heterocyclic compounds as pharmaceutical
    Patent number: 5869495
    Abstract: A compound of Formula (I) ##STR1## or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, whereinA.sup.1, A.sup.2, A.sup.3, R.sup.2, X, Y and n are as defined herein; a pharmaceutical composition comprising such a compound and the use of such a compound or composition in medicine.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Haigh, John Thomas Sime
  • Heterocyclic compounds as pharmaceutical
    Patent number: 5827865
    Abstract: Compounds of Formula (I)A.sup.1 --X--(CH.sub.2).sub.n --O--A.sup.2 --A.sup.3 --Y.R.sup.2(I)or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein A.sup.1, A.sup.2, A.sup.3, R.sup.2, X, Y and n are as defined herein; a pharmaceutical composition comprising such a compound and the use of such a compound or composition in medicine as described.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 27, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Haigh, John Thomas Sime
  • Enzymatic preparation of monic acids
    Patent number: 5726049
    Abstract: A process for the production of monic acids which comprises contacting a corresponding pseudomonic acid or an ester thereof with a hydrolase enzyme from a suitable microorganism, in particular Streptomyces sp.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: March 10, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Esme Faith Hayes, John Thomas Sime, Stefan Roland Woroniecki, David Alan Yeandle