Patents by Inventor John To

John To has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11319571
    Abstract: Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation. Computer-readable storage devices and systems, e.g., for use in the described methods.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: May 3, 2022
    Assignee: The General Hospital Corporation
    Inventor: John M. Higgins
  • Patent number: 11318168
    Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: May 3, 2022
    Assignee: OSIRIS THERAPEUTICS, INC.
    Inventors: Steven Michael Sinclair, Alla Danilkovitch, Malathi Sathyamoorthy, Jin-Qiang Kuang, Sandeep Dhall, Yishan Liu, Anthony John Melchiorri, Matthew Robert Moorman, Mena Schiano Lo Moriello, Anne Allgood Lerch
  • Patent number: 11318409
    Abstract: Methods and materials for the selective capture and storage of preselected materials from gas streams using metal organic framework (MOF) materials are described. In various embodiments preselected target material gases could include noble gasses such as Kr, Xe, Rn, Arultramicro to mesopore frameworks for selective separation and storage of noble gases, other gasses such as I2 or other particular isotopes either naturally occurring or man-made, or another preselected gas capture material such as a target material for legal, regulatory or treaty compliance, or a preselected material from a particular process such as a cleaning or etching agent from semiconducting or microelectronic manufacture, or a portion of an anesthetic gas such as nitrous oxide, isoflurane, sevoflurane or a fluorinated ethers.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: May 3, 2022
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Praveen K. Thallapally, John D. Vienna
  • Patent number: 11319329
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: May 3, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener
  • Patent number: 11324103
    Abstract: A modular laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target directly illuminated by laser pulses, a circulation pump within the liquid metal flow system for circulating the liquid metal, a laser pulse emitter configured to transmit laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target, the focusing optics directing the laser pulses to strike the metal target at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to enable the X-ray pulses to exit the chamber.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 3, 2022
    Assignees: Research Instruments Corporation, Brown University
    Inventors: Daniel John DeCiccio, Christoph Rose-Petruck
  • Patent number: 11323507
    Abstract: A server system including a first server to execute first role, other server to execute at other role, spare server and management layer server. The management layer server is configured to allocate first group of users to access first server and other group of users to access other server, receive status information sent by first server and status information sent by other server, analyse status information to determine an operational status of first server and operational status of other server, update role of spare server to first role when operational status of first server indicates failed state and reallocate first group of users to the spare server, and update a role of another spare server to the other role when the operational status of the other server indicates a failed state and reallocate the other group of users to the other spare server.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: May 3, 2022
    Assignee: Supercell Oy
    Inventors: John Nicholas Derome, Robert Kamphuis
  • Patent number: 11319336
    Abstract: The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: May 3, 2022
    Inventors: William G. Kerr, John D. Chisholm
  • Patent number: 11317691
    Abstract: Containers are described herein for the transportation and distribution of replaceable consumer products, e.g. interchangeable shaving assemblies. The containers described herein include a mechanism to securely hold the container in predetermined open and closed positions. The interior of the container may provided features which serve to hold and protect the shaving assemblies when not in use, e.g., during transport or storage.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: May 3, 2022
    Assignee: SL IP COMPANY LLC
    Inventors: Craig A. Provost, John W. Griffin, William E. Tucker, Aaron G. Cantrell
  • Patent number: 11318563
    Abstract: A system and method for laser cutting a plurality of parts, for example metal chassis components, using a plurality of laser cutting apparatuses is provided. The system includes a plurality of the laser cutting apparatuses disposed in a single enclosed cell for simultaneously trimming multiple parts. The system also includes at least one inner chamber and at least one set of double doors for transferring the parts in and out of the enclosed cell without any light escaping the cell. The parts are conveyed through the first door to the inner chamber while the second door is closed, and through the second door to the enclosed cell while the first door is closed. The system also includes robots continuously preloading and unloading the parts to maximize the laser trimming time.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: May 3, 2022
    Assignee: Magna International Inc.
    Inventors: John Richard Potocki, Alexander Zak
  • Patent number: 11320601
    Abstract: In general, the present disclosure is directed to locking arrangements for use with optical subassembly housings, such as small form-factor pluggable (SFFP) housings, that include a handle member configured to rotate about the housing to allow a user to select a target/desired orientation. Preferably, the locking arrangement couples to a pluggable housing that is configured to removably couple into a receptacle of an optical transceiver cage or other suitable enclosure. The locking arrangement further includes a handle member rotatably coupled to the pluggable housing, the handle member being configured to allow the pluggable housing to releasably lock within the receptacle. The handle member is also preferably configured to maintain a user-selected orientation such that the handle member remains at a given angle relative to the pluggable housing in the absence of a user-supplied force.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: May 3, 2022
    Assignee: Applied Optoelectronics, Inc.
    Inventors: Kai-Sheng Lin, John Cheng, Ziliang Cai
  • Patent number: 11323784
    Abstract: A method of operating a battery powered telemetric device configured with a processor, a sensor to measure data to indicate the contents or usage of a product within an asset generating sample data, data storage, at least one battery and a transmitter, includes keeping in the data storage at least one instance of previous data samples represented in a previously transmitted packet, awakening the telemetric device at variable time intervals programmed according to pre-determined user-defined characteristics so that the sensor provides sample data to the data storage to indicate the contents or usage of the product within the asset wherein the telemetric device is otherwise asleep to minimize battery drain, storing all the sample data since the transmission of the previously transmitted packet and the kept at least one instance of previous data samples represented in the previously transmitted packet in the data storage as all the stored sample data, transmitting a packet including representations of the conten
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: May 3, 2022
    Inventors: Julien Dominique Rivals, John Richard Haddy
  • Patent number: 11318897
    Abstract: A vehicle includes an electrified propulsion system powered by a traction battery. The vehicle also includes an electrical distribution system (EDS) to pass current to and from the traction battery. The EDS is provided with at least one flexible electrical distribution component (FEDC) including a plurality of individual conductor paths. At least one of the individual conductor paths defines a typical width and a reduced width narrowed portion sized to operate as a fuse and thereby break an electrical circuit of the at least one individual conductor path in response to heat generated from conducting an electrical current greater than a predetermined threshold.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: May 3, 2022
    Assignee: Ford Global Technologies, LLC
    Inventors: John Paul Gibeau, Benjamin A. Tabatowski-Bush, Baojin Wang
  • Patent number: 11324028
    Abstract: Methods, systems, and devices for wireless communications are described. A base station may configure a user equipment (UE) with a list of transmission configuration indicator (TCI) state patterns where each entry in the list may correspond to a different TCI state pattern. The base station may transmit an indication of a selected entry from the TCI state pattern list and transmit a grant to the UE indicating that resources have been allocated in for transmitting a transport block (TB). The UE may receive the grant and attempt to receive the TB in accordance with the indicated TCI state pattern. The UE may generate multi-bit feedback to indicate whether the UE was able to successfully decode the TB and transmit the feedback to the base station. The base station may use the multi-bit feedback for determining whether to select a different TCI state pattern.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 3, 2022
    Assignee: QUALCOMM Incorporated
    Inventors: Kiran Venugopal, Makesh Pravin John Wilson, Tianyang Bai, Juan Montojo, Xiaoxia Zhang, Tao Luo
  • Patent number: 11320160
    Abstract: A heating, ventilation, and/or air conditioning (HVAC) system includes a mobile air conditioning unit configured to separately dock with each docking station of a plurality of docking stations. The mobile air conditioning unit includes a refrigerant circuit configured to condition an airflow to produce a conditioned airflow and a transportation system configured to autonomously relocate the mobile air conditioning unit.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: May 3, 2022
    Assignee: Johnson Controls Tyco IP Holdings LLP
    Inventors: Jedidiah O. Bentz, Shaun B. Atchison, Aneek M. Noor, Drew H. Carlton, John W. Uerkvitz
  • Patent number: 11320143
    Abstract: In one aspect a pilot assembly is disclosed for use with a flare having a first flare stack and a second flare stack, each having discharge ends. The pilot assembly comprises a pilot nozzle assembly, a pilot inlet pipe having a pilot fuel inlet, and a pilot ignition system. The pilot nozzle assembly comprises a connecting member, a pilot nozzle inlet, a first pilot nozzle and a second pilot nozzle. The pilot nozzle assembly can direct a quantity of pilot gas received via the pilot inlet pipe out through the first and second pilot nozzles. The first and second pilot nozzles may both be positioned adjacent the discharge end of either one of the first or second flare stacks. Alternatively, the first pilot nozzle may be positioned adjacent the first flare stack's discharge, and the second pilot nozzle may be positioned adjacent the second flare stack's discharge end.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: May 3, 2022
    Assignee: FLARETECH INC.
    Inventor: Bo-John Cassidy
  • Patent number: 11320240
    Abstract: The present disclosure relates to a firearm which may include a frame with a first outer wall, and a second outer wall opposite the first outer wall. A laser module may be disposed between the first and second outer walls. An alignment pin may be in communication with the first outer wall and may be configured to move the laser module relative to the frame.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: May 3, 2022
    Assignee: Crosman Corporation
    Inventors: John A. Kowalczyk, Jr., Jeffrey W. Mock, Jeffrey D. Tuller
  • Patent number: 11318626
    Abstract: Mechanisms to realize lightweight rotational joints having independently adjustable compliance in one or more degrees of freedom are presented herein. In addition, robotic systems incorporating one or more compliant rotational joints as described herein are also presented. In some embodiments, a robotic structure includes a member having adjustable rotational compliance. One or more compliance elements are arranged around a rotational joint. The position of the one or more compliance elements relative to the rotational joint is adjusted to change the overall joint compliance. In some embodiments, the change of position of the one or more compliance elements relative to the rotational joint changes both the induced displacement of the compliance element for a given angular displacement of the rotational joint and the length of the moment arm from the rotational joint to the compliance element.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: May 3, 2022
    Assignee: Empower Robotics Corporation
    Inventor: John W. Meincke, II
  • Patent number: 11317942
    Abstract: A support apparatus for supporting a trocar while the trocar extends through a body wall of a patient includes an inflatable collar and a slidable abutment collar commonly connected for engagement onto the trocar following which the slide collar is released to slide along the trocar. The inflatable collar is inflated to a set size by a manually operable pump on the slidable collar operated by squeezing finger abutments together up to a latch so that threaded portion expels the inflation fluid. The abutment member is shaped to be received on an outer surface of the trocar and adjustable longitudinally of the trocar sleeve so as to be located at a selected position by a manually movable latch collar. The inflatable collar and slidably collar are held connected by a manually operable release.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: May 3, 2022
    Inventors: John Stephen Pacak, Heather Dawn Diamond, Damian Raymond Muldoon, Shane Gerard Ward, Brian Fergus Murphy, William James Cannon, Luke Patrick Keaveney
  • Patent number: 11318203
    Abstract: The invention provides a liquid-dispersible powder comprising nanoscale grains of matrix embedded with one or more isolated nanoparticles and a composition for the magnetic nanoparticle hyperthermia (MNH) treatment of tumours comprising nanoscale grains of matrix material containing one or more isolated nanoparticles. The invention also provides a method of production of a liquid-dispersible powder described herein, the method comprising the steps of providing nanoparticles prepared under ultra-high vacuum (UHV) gas phase conditions; co-depositing the nanoparticles within a matrix material under UHV gas phase conditions; and grinding the film to a fine powder comprising grains of groups of matrix material isolated nanoparticles.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: May 3, 2022
    Assignee: Ubicoat Ltd
    Inventors: Robert Davidson Binns, Patrick William John Kinmont
  • Patent number: 11318553
    Abstract: An embodiment of a method includes fabricating a first single crystal boule having a uniform composition and grain orientation. The first uniform single crystal boule is divided into a first plurality of layered shapes. The shapes of the first plurality are stacked with at least a second plurality of layered shapes along a first axis. The second plurality of layered shapes have at least one physical aspect differing from at least one corresponding physical aspect of the first plurality of layered shapes. The first plurality of layered shapes and at least the second plurality of layered shapes are joined via a field assisted sintering technique (FAST) to form a bulk component.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: May 3, 2022
    Assignee: Raytheon Technologies Corporation
    Inventors: Paul Sheedy, John A. Sharon, Wayde R. Schmidt