Patents by Inventor John W. Frost
John W. Frost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9499465Abstract: Methods for producing bio-terephthalic acid and bio-isophthalic acid are provided. The methods comprise a cycloaddition reaction to produce bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic from bio-isoprene and bio-acrylic acid. An aromatization reaction produces bio-para-toluic acid and bio-meta-toluic acid from the bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic. An oxidation reaction produces the bio-terephthalic acid and iso-phthalic acid from the bio-para-toluic acid and bio-meta-toluic acid.Type: GrantFiled: March 14, 2014Date of Patent: November 22, 2016Assignee: Board of Trustees of Michigan State UniversityInventor: John W. Frost
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Publication number: 20160176799Abstract: A method for isolating and purifying shikimic acid from a fermentation broth is provided. The method includes performing a liquid-liquid extraction on the fermentation broth with an alcohol solution to generate an extract, crystallizing solids from the extract, dissolving the solids in a second alcohol solution to generate a solution having shikimic acid, and filtering the solution having shikimic acid through a filter that does not contain ion exchange resins. Methods for dehydrating the shikimic acid to yield p-hydroxybenzoic acid are also provided.Type: ApplicationFiled: December 18, 2015Publication date: June 23, 2016Inventors: Karen M. FROST, John W. FROST
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Publication number: 20160031787Abstract: Methods for producing bio-terephthalic acid and bio-isophthalic acid. Methods comprise a cycloaddition reaction to produce bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic from bio-isoprene and bio-acrylic acid. An aromatization reaction produces bio-para-toluic acid and bio-meta-toluic acid from the bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic. An oxidation reaction produces the bio-terephthalic acid and isophthalic acid from the bio-para-toluic acid and bio-meta-toluic acid.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventor: John W. FROST
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Patent number: 9073867Abstract: Provided herein are processes for preparing caprolactam from a starting material such as one or more of the cis,cis-, cis,trans- and trans,trans-double-bond isomers of muconamide, muconic acid ester, or muconic acid. The starting material, intermediates, and caprolactam prepared therefrom can contain carbon atoms derived from biomass containing detectable 14C content determined according to ASTM D6866 and optionally containing a 14C content up to 0.0000000001% (one part per trillion). Caprolactam so prepared can be used to make various polyamides.Type: GrantFiled: April 9, 2012Date of Patent: July 7, 2015Assignee: Amyris, Inc.Inventors: Laetitia Coudray, Vu Bui, John W. Frost, Dirk Schweitzer
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Patent number: 8492581Abstract: The present invention provides improved process for the sulfonation of hydroxyaromatics amenable to direct isolation of the sulfonylated hydroxyaromatics in their free-acid forms. The process allows for the recyclization of sulfuric acid and minimizes waste. The starting materials are from a renewal resource, e.g., biomass, and contain detectable 14C up to a 14C content of 0.0000000001% (one part per trillion). The products made include sulfonated catechol, disulfonated pyrogallol and sulfonated protocatechuic acid.Type: GrantFiled: August 20, 2010Date of Patent: July 23, 2013Assignee: Amyris, Inc.Inventors: John W Frost, Vu Bui
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Patent number: 8426639Abstract: The present invention relates to the isomerization of cis,cis and/or cis,trans muconic acid or esters thereof to trans,trans muconic acid or esters thereof and to the esterification of such muconic acids.Type: GrantFiled: June 16, 2010Date of Patent: April 23, 2013Assignee: Amyris, Inc.Inventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui
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Patent number: 8415496Abstract: The present invention relates to polyesters prepared from benzene, cyclohexene and cyclohexane compounds having carboxylic acid groups at the 1 and 4, and optionally the 2, positions, such as terephthalic acid or dimethyl terephthalates, and alkylene glycols, such ethylene glycol or 1,4-butane diol. The invention also relates to processes for preparing such polyesters. The invention also relates to such polyesters derived from starting materials derived from renewable resources.Type: GrantFiled: June 16, 2010Date of Patent: April 9, 2013Assignee: Amyris, Inc.Inventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Edward Paschke, Douglas A. Wicks
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Publication number: 20130085255Abstract: Provided herein are processes for preparing caprolactam from a starting material such as one or more of the cis,cis-, cis,trans- and trans,trans-double-bond isomers of muconamide, muconic acid ester, or muconic acid. The starting material, intermediates, and caprolactam prepared therefrom can contain carbon atoms derived from biomass containing detectable 14C content determined according to ASTM D6866 and optionally containing a 14C content up to 0.0000000001% (one part per trillion). Caprolactam so prepared can be used to make various polyamides.Type: ApplicationFiled: April 9, 2012Publication date: April 4, 2013Applicant: Amyris, Inc.Inventors: Laetitia Coudray, Vu Bui, John W. Frost, Dirk Schweitzer
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Patent number: 8372621Abstract: Novel enzymes and novel enzymatic pathways for the pyruvate-based synthesis of shikimate or at least one intermediate thereto or derivative thereof, nucleic acids encoding the enzymes, cells transformed therewith, and kits containing said enzymes, cells, or nucleic acid. A KDPGal aldolase is used to perform condensation of pyruvate with D-erythrose 4-phosphate to form 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP); a 3-dehydroquinate synthase is used to convert the DAHP to 3-dehydroquinate (DHQ); DHQ dehydratase can then convert DHQ to the key shikimate intermediate, 3-dehydroshikimate.Type: GrantFiled: July 20, 2010Date of Patent: February 12, 2013Assignee: Board of Trustees Operating Michigan State UniversityInventor: John W. Frost
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Patent number: 8367859Abstract: The present invention relates to cyclohexanes having carboxylate derivatives at the 1 and 4, and optionally the 2, position. The invention also relates to processes for preparing such compounds wherein a portion of the starting materials utililzed is derived from renewable resources.Type: GrantFiled: June 16, 2010Date of Patent: February 5, 2013Assignee: Amyris, Inc.Inventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Douglas A. Wicks
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Patent number: 8367858Abstract: The present invention relates to novel substituted and unsubstituted terephthalic acid and carboxylate derivatives and products prepared therefrom having a significant renewable content. The invention also relates to processes for preparing substituted and unsubstituted terephthalic and carboxylate derivatives thereof wherein a portion of the starting materials utilized is derived from renewable resources. The invention also relates to novel cyclohexene based intermediates prepared in these processes and to conversion of these intermediates to substituted and unsubstituted cyclohexane-1,4-dicarboxylates and carboxylate derivatives thereof and novel forms of the resulting products having renewable content. The invention also relates to products prepared from substituted and unsubstituted terephthalic acid and carboxylate derivatives thereof derived from starting materials derived from renewable resources.Type: GrantFiled: June 16, 2010Date of Patent: February 5, 2013Assignee: Amyris, Inc.Inventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Douglas A. Wicks
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Patent number: 8367819Abstract: In various embodiments, the present invention can involve a method of synthesizing ?-amino-?-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ?-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce ?-amino-?caprolactam, deaminating to produce ?-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ?-caprolactam and then polymerizing, wherein the ?-caprolactam is derived from L-lysine.Type: GrantFiled: July 1, 2011Date of Patent: February 5, 2013Assignee: Board of Trustees of Michigan State UniversityInventor: John W. Frost
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Patent number: 8329445Abstract: The present invention provides methods, enzymes, and cells for the biosynthetic production of phloroglucinol from malonyl-CoA, which is ultimately obtained from simple starting materials such as glucose; also provided are methods for preparing derivatives of biosynthetic phloroglucinol, including, e.g., resorcinol.Type: GrantFiled: April 7, 2011Date of Patent: December 11, 2012Assignee: Board of Trustees of Michigan State UniversityInventor: John W. Frost
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Patent number: 8283466Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.Type: GrantFiled: February 20, 2008Date of Patent: October 9, 2012Assignee: Board of Trustees of Michigan State UniversityInventor: John W. Frost
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Publication number: 20120142886Abstract: In various embodiments, the present invention can involve a method of synthesizing ?-amino-?-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ?-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce ?-amino-?caprolactam, deaminating to produce ?-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ?-caprolactam and then polymerizing, wherein the ?-caprolactam is derived from L-lysine.Type: ApplicationFiled: July 1, 2011Publication date: June 7, 2012Applicant: Board of Trustees of Michigan State UniversityInventor: John W. Frost
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Patent number: 8080397Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.Type: GrantFiled: November 20, 2009Date of Patent: December 20, 2011Assignee: Board of Trustees Operating Michigan State UniversityInventors: John W. Frost, Karen M. Frost
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Publication number: 20110288311Abstract: The present invention relates to novel substituted and unsubstituted terephthalic acid and carboxylate derivatives and products prepared therefrom having a significant renewable content. The invention also relates to processes for preparing substituted and unsubstituted terephthalic and carboxylate derivatives thereof wherein a portion of the starting materials utilized is derived from renewable resources. The invention also relates to novel cyclohexene based intermediates prepared in these processes and to conversion of these intermediates to substituted and unsubstituted cyclohexane-1,4-dicarboxylates and carboxylate derivatives thereof and novel forms of the resulting products having renewable content. The invention also relates to products prepared from substituted and unsubstituted terephthalic acid and carboxylate derivatives thereof derived from starting materials derived from renewable resources.Type: ApplicationFiled: June 16, 2010Publication date: November 24, 2011Applicant: Draths CorporationInventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Douglas A. Wicks
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Publication number: 20110288263Abstract: The present invention relates to polyesters prepared from benzene, cyclohexene and cyclohexane compounds having carboxylic acid groups at the 1 and 4, and optionally the 2, positions, such as terephthalic acid or dimethyl terephthalates, and alkylene glycols, such ethylene glycol or 1,4-butane diol. The invention also relates to processes for preparing such polyesters. The invention also relates to such polyesters derived from starting materials derived from renewable resources.Type: ApplicationFiled: June 16, 2010Publication date: November 24, 2011Applicant: Draths CorporationInventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Edward Paschke, Douglas A. Wicks
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Publication number: 20110288310Abstract: The present invention relates to cyclohexanes having carboxylate derivatives at the 1 and 4, and optionally the 2, position. The invention also relates to processes for preparing such compounds wherein a portion of the starting materials utililzed is derived from renewable resources.Type: ApplicationFiled: June 16, 2010Publication date: November 24, 2011Applicant: Draths CorporationInventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Douglas A. Wicks
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Publication number: 20110282078Abstract: The present invention relates to cyclohexenes having carboxylate derivatives at the 1 and 4, and optionally the 2, position. The invention also relates to processes for preparing such compounds wherein a portion of the starting materials utilized is derived from renewable resources.Type: ApplicationFiled: June 16, 2010Publication date: November 17, 2011Applicant: Draths CorporationInventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui, Douglas A. Wicks