Abstract: The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

Abstract: The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

Abstract: Silver halide color photographic elements having multiple color imaging layers contain a permanent, pre-formed magenta dye that is present in an amount to provide a status M green density greater than 0.005 per mg/m2. This dye provides minimum density at lower cost and enables lower dye levels and a reduced organic load that may lead to improved film physical properties.

Abstract: Silver halide color photographic elements having multiple color imaging layers contain a permanent, pre-formed magenta dye that is present in an amount to provide a status M green density greater than 0.005 per mg/m2. This dye provides minimum density at lower cost and enables lower dye levels and a reduced organic load that may lead to improved film physical properties.

Abstract: Silver halide color photographic elements having multiple color imaging layers contain a permanent, pre-formed yellow colorant that is present in an amount to provide a status M blue density greater than 0.003 per mg/m2. This colorant provides minimum density at lower cost and can be incorporated with minimal or no organic solvents and thus enable a reduced organic load that may lead to improved film physical properties.

Abstract: Silver halide color photographic elements having multiple color imaging layers contain a permanent, pre-formed yellow colorant that is present in an amount to provide a status M blue density greater than 0.003 per mg/m2. This colorant provides minimum density at lower cost and can be incorporated with minimal or no organic solvents and thus enable a reduced organic load that may lead to improved film physical properties.

Abstract: A non-infrared sensitized low silver photographic element with a non-light sensitive layer, preferably an antihalation layer, containing a diphenylaminocyclopentene heptacyanine benzothiazolium infrared dye where the benzothiazolium groups have electron-withdrawing substituents on the phenyl ring and solubilzed alkyl groups on the nitrogen. The infrared dye can be present as a liquid-crystalline dispersion. This class of infrared dyes form J-aggregated species in a liquid-crystalline or a solid particle dispersion with high IR density and low visible absorbance.

Abstract: A non-infrared sensitized low silver photographic element with a non-light sensitive layer, preferably an antihalation layer, containing a diphenylaminocyclopentene heptacyanine benzothiazolium infrared dye where the benzothiazolium groups have electron-withdrawing substituents on the phenyl ring and solubilzed alkyl groups on the nitrogen. The infrared dye can be present as a liquid-crystalline dispersion. This class of infrared dyes form J-aggregrated species in a liquid-crystalline or a solid particle dispersion with high IR density and low visible absorbance.

Abstract: The invention relates to a composition comprising a colloid which is stable under physiological pH and ionic strength, said colloid comprising particles having a silica core and a shell: a) wherein said shell comprises a cross-linked poly(ethylene)imine polymer having amine functionalities; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 50% of said polymer in the colloid is bound to the core surfaces, wherein the polymer having amine functionalities has an average molecular weight less than 100,000 g/mol, the composition has a H of between 6 and 8; and d) wherein the colloid contains between 300 and 6000 .?mol amine-monomer/g core particles.

Abstract: There are disclosed colloids containing polymer-modified core-shell particle carrier. The described colloids containing core-shell nanoparticulate carrier particles wherein the shell contains a polymer having amine functionalities. The described carrier particles are stable under physiological conditions. The carriers can be bioconjugated with biological, pharmaceutical or diagnostic components.

Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

Abstract: The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.

Abstract: This invention relates to a multilayer silver halide photographic element, generally processed with phenylenediamine based developer solutions, comprising a support bearing a cyan dye image-forming unit comprised of at least one red-sensitive silver halide emulsion layer having associated therewith at least one cyan dye-forming coupler, a magenta dye image-forming unit comprising at least one green-sensitive silver halide emulsion layer having associated therewith at least one magenta dye-forming coupler, and a yellow dye image-forming unit comprising at least one blue-sensitive silver halide emulsion layer having associated therewith at least one yellow dye-forming coupler, wherein at least one layer additionally contains a 2-substituted-5-amino-1-napthol DIR according to Formula (I): wherein: X is chosen from among hydrogen, halogen atoms, an alkyl group with 6 carbon atoms or less or a N-substituted carbamoyl group where the N substituent is either an alkyl group with 6 carbon atoms or less or an ar

Abstract: Disclosed is a process for forming a 1H-pyrazolo (1,5-b)-[1,2,4]-triazole compound by ring closing a pyrazoloamidine compound comprising reacting the amidine with an oxidizing agent having a reduction potential vs Ag/AgCl that is more positive than −0.16V and less than +1.43V in the presence of a halogen atom. The invention also discloses certain triazole compounds that are successfully made by the conventional process. The process and compounds of the invention provide improved yields and reduce or eliminate unwanted side-reactions.

Abstract: Disclosed is a process for forming a 1H-pyrazolo (1,5-b)-[1,2,4]-triazole compound by ring closing a pyrazoloamidine compound comprising reacting the amidine with an oxidizing agent having a reduction potential vs Ag/AgCl that is more positive than −0.16V and less than +1.43V in the presence of a halogen atom. The invention also discloses certain triazole compounds that are successfully made by the conventional process. The process and compounds of the invention provide improved yields and reduce or eliminate unwanted side-reactions.

Abstract: Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a bicyclic azole dye-forming coupler compound having Formula I: wherein: BA represents a bicyclic azole coupler nucleus with —(C(R1)(R2))P— bonded to a ring carbon in a non-coupling position of the coupler nucleus; p is 1 or 2, and each R1 and R2 is independently selected from H and a substituent group, provided that any two of R1 and R2 may join to form a ring; Ra and Rb are each independently selected from H and a substituent group, provided that substituent groups may join to form a ring; each Y is an independently selected substituent and m is 0-4; X is selected from the group consisting of —C(O)—, —S(O)2—, —S(O)—, and —P(O)(OH)—; W is a connecting group having a chain of up to four atoms between X and Z, and n=0 or 1; and a) when n=0, Z is —NHR5 where R5 is H or a substituent, and

Abstract: Disclosed is a photographic element complising a light sensitive silver halide emulsion layer having associated therewith a cyan dye forming coupler having Formula (I): wherein R1 and R3 independently represent hydrogen or an alkyl group; R2 represents a carbocyclic or heterocyclic aromatic group; n represents 1, 2, or 3; each X is an independently selected substituent where at least one X located at a position of the phenyl ring meta or para to the sulfonyl group and is either an alkoxy group having a branched carbon or an aiyloxy group; and Z represents hydrogen or a group that can be split off by the reaction of the coupler with an oxidized color-developing compound; provided that the substituents of the compound of formula (I) are selected so that the compound has a melting point of 160° C. or less. The element provides improved phase stability during manufacturing while exhibiting satisfactory hue and dye light stability.

Abstract: Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a cyan dye-forming coupler represented by Formula (I): wherein: each R1 and R3 is an independently selected substituent, m is 0 to 5, and p is 0 to 2; X is hydrogen or a coupling-off group; W and W2 represent the atoms necessary to complete rings; and R2 is an alkyl or aryl group. The element provides desirable hue properties and ease of synthesis.

Abstract: Disclosed is a photographic element comprising at least one light sensitive silver halide emulsion layer having associated therewith: (A) a phenolic cyan dye-forming "NB coupler";(B) a high boiling solvent having Formula (II):R.sup.3 OO--C--(--G--)--C--OO--R.sup.4 (II)wherein:R.sup.3 and R.sup.4 represent independently selected alkyl or aryl groups; andG represents an alkyl (including cycloalkyl and aralkyl) containing linking group; and(C) a stabilizer having Formula (III): ##STR1## wherein each Y is an independently selected substituent and m is 0 to 4; andeach T is an independently selected substituent and p is 0 to 4.