Abstract: A system comprises a memory, a plurality of electrodes, sensing circuitry, and processing circuitry. The sensing circuitry configured to determine one or more tissue impedance values via the electrodes, wherein the tissue impedance values vary as a function of ejection fraction of a heart of a patient. The processing circuitry configured to determine, at least based on the one or more tissue impedance values, a stroke metric indicative of a stroke status of the patient, and store the stroke metric in a memory.

Abstract: In some examples, a device includes at least three electrodes a first pair of electrodes and a second pair of electrodes. The device also includes circuitry configured to generate a first cardiac signal based on a first differential signal received across the first pair, generate a first brain signal based on the first differential signal received across the first pair, generate a second cardiac signal based on a second differential signal received across the second pair, and generate a second brain signal based on the second differential signal received across the second pair. The circuitry is also configured to output a composite cardiac signal based on the first cardiac signal and the second cardiac signal and to output a composite brain signal based on the first brain signal and the second brain signal.

Abstract: Devices, systems, and techniques are described for detecting stroke or seizure with a compact system. For example, a system includes a memory, a plurality of electrodes, and sensing circuitry configured to sense, via at least two electrodes of the plurality of electrodes, electrical signals from a patient, and generate, based on the electrical signals, physiological information. The system may also include processing circuitry configured to receive, from the sensing circuitry, the physiological information, determine, based on the physiological information, a seizure metric indicative of a seizure status of the patient and a stroke metric indicative of a stroke status of the patient, and store the seizure metric and the stroke metric in the memory. A housing may carry the plurality of electrodes and contain both of the sensing circuitry and the processing circuitry.

Abstract: A system comprises a sensor device and processing circuitry. The sensor device comprises a housing configured to be disposed above shoulders of a patient, a plurality of electrodes on the housing, a motion sensor, and sensing circuitry configured to sense a brain electrical signal and a cardiac electrical signal via the electrodes, and a motion signal via the motion sensor. The processing circuitry is configured to determine values over time of one or more parameters from the brain electrical signal, determine values over time of one or more parameters from the cardiac electrical signal, and generate at least one of a detection, prediction, or a classification a condition of the patient based on the values and the motion signal.

Abstract: Expandable devices are disclosed herein. Several of the embodiments are directed towards an expandable device comprising a mesh configured to be expanded at a blood vessel bifurcation of a human patient. The mesh may comprise a tubular body portion and one or more circumferentially discontinuous articulating portions. The mesh may be expanded such that the one or more articulating portions are positioned at an angle to the tubular body portion.

Abstract: Vasculature models and associated systems and methods are disclosed herein. In some embodiments, the model comprises a tube including a lumen extending therethrough, a synthetic thrombus including a magnetic component, and a magnetized member. The thrombus is sized to be positioned within the lumen, and the magnetized member is positioned peripheral to the thrombus such that a radially outward force is exerted on the thrombus via the magnetized member. The tube may be part of a network of tubes that generally resemble human neurovasculature.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.

Abstract: The present invention provides a sabot (8) comprising a first material structure (12, 14) and a second material structure, wherein the first material structure is a lattice and wherein the second material structure is a solid. A munition (100) and a method of manufacturing a sabot are also provided.

Abstract: Devices for removing clot material from a blood vessel lumen and associated systems and methods are disclosed herein. A clot retrieving device may include, for example, an elongated member, a cover having proximal, intermediate, and distal portions. The cover may be slideably coupled to the distal region of the elongated member at a connector. The cover may have an inner layer and an outer layer. The inner layer may have (a) a first cross-sectional dimension at the proximal portion of the cover, (b) a distally increasing cross-sectional dimension along the intermediate portion of the cover, and (c) a second cross-sectional dimension at the distal portion of the cover, wherein the second cross-sectional dimension is greater than the first cross-sectional dimension. The outer layer may have a cross-sectional dimension that is generally constant along the distal portion and the intermediate portion of the cover.

Abstract: A system for detecting strokes includes a sensor device configured to obtain physiological data from a patient, for example brain activity data. A computing device communicatively coupled to the sensor device is configured to receive the physiological data and compare it with reference data. The reference data can be patient data from an opposite brain hemisphere to the hemisphere being interrogated or the reference data can be non-patient data from stroke and normal patient populations. Based on comparison of the physiological data and the reference data, the system indicates whether the patient has suffered a stroke.

Abstract: A system for detecting strokes includes a sensor device configured to obtain physiological data from a patient, for example brain activity data. The sensor device can include electrodes configured to be disposed at the back of the patient's neck or base of the skull. The electrodes can detect electrical signals corresponding to brain activity in the P3, Pz, and/or P4 brain regions or other brain regions. A computing device communicatively coupled to the sensor device is configured to receive the physiological data and analyze it to indicate whether the patient has suffered a stroke.

Abstract: A system for detecting strokes includes a sensor device configured to obtain physiological data from a patient, for example brain activity data. The sensor device can include electrodes configured to be disposed at the back of the patient's neck or base of the skull. The electrodes can detect electrical signals corresponding to brain activity in the P3, Pz, and/or P4 brain regions or other brain regions. A computing device communicatively coupled to the sensor device is configured to receive the physiological data and analyze it to indicate whether the patient has suffered a stroke.

Abstract: A system for detecting strokes includes a sensor device configured to obtain physiological data from a patient, for example brain activity data. A computing device communicatively coupled to the sensor device is configured to receive the physiological data and compare it with reference data. The reference data can be patient data from an opposite brain hemisphere to the hemisphere being interrogated or the reference data can be non-patient data from stroke and normal patient populations. Based on comparison of the physiological data and the reference data, the system indicates whether the patient has suffered a stroke.

Abstract: Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

Abstract: Vasculature models and associated systems and methods are disclosed herein. In some embodiments, the model comprises a tube including a lumen extending therethrough, a synthetic thrombus including a magnetic component, and a magnetized member. The thrombus is sized to be positioned within the lumen, and the magnetized member is positioned peripheral to the thrombus such that a radially outward force is exerted on the thrombus via the magnetized member. The tube may be part of a network of tubes that generally resemble human neurovasculature.

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Abstract: Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.