Abstract: Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

Abstract: Medical devices that include a tubular member with a plurality of braided filaments, each filament crossing another of the filaments at a respective crossing point forming sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores have an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device with pores substantially free of webs formed by antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by antithrombogenic material thereby permitting the pores to be substantially free of webs.

Abstract: Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: Coating methods and related devices are provided. Such devices can include stents. For example, the device can comprise a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can also comprise an anti-thrombogenic coating distributed over at least a portion of the device such that the pores are substantially free of webs formed by the coating.

Abstract: A device for intravascular intervention can comprise an intervention element and an elongate manipulation member. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The hooked portion can have a first segment, a second segment, and a bend between the first and second segments, with the first segment and the second segment located on different sides of the intervention element. At least one of the first segment or the second segment can have an extending portion that extends into a region that is (i) between a top side and a bottom side of the intervention element, and (ii) distal to a proximal part of the intervention element. The extending portion and the proximal part can be aligned such that a line extending in a proximal-distal direction intersects the extending portion and the proximal part.

Abstract: The invention relates to a common carrier munition ammunition device, more particularly to common carrier payload delivery shell. There is provided a common carrier munition comprising a tail unit, a main body which comprises a payload cavity for receiving a payload, a fuze, and located between said main body and the fuze an ogive element, wherein the tail unit and main body comprise cooperatively engaging male and female threaded portions, wherein at least one of the threads is a shearable thread.

Abstract: A medical device, for insertion into an anatomical vessel, can include a sheath, a delivery wire, and a frame or vessel-engaging member. The delivery wire can have a first stop, a second stop, and a coupling area between the first and second stops. The coupling area can be disposed within and movable relative to the sheath. The frame or vessel-engaging member can have a matrix of cells, first and second tapered sections, and interlocking members. The interlocking members can be attached to the tapered sections. The interlocking members can be releasably coupled to the delivery wire at the coupling area with the interlocking members surrounded and held in the coupling area by the sheath. The interlocking members can be movable relative to the sheath, and the interlocking members can separate from each other when the interlocking members are positioned distal to the sheath.

Abstract: A device for intravascular intervention can comprise an intervention element, an elongate manipulation member, and a joining element. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The joining element can substantially permanently attach the hooked portion to the intervention element.

Abstract: Described herein are vascular remodeling devices that include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchors the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: A method for making large pressure vessels using a composite over-wrap process and a soluble mandrel structure that is scalable to a much larger vessel size than can normally be accommodated by the over-wrap process. The method allows the production of very large, lightweight vessels with no seams and no metal liners. Extensions of the method provide for the fabrication of fully embedded threaded or non-threaded bosses of composite materials, and fully embedded longitudinal and circumferential stringers or stiffeners.

Abstract: Coating methods and related devices are provided. Such devices can include stents. For example, the device can comprise a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can also comprise an anti-thrombogenic coating distributed over at least a portion of the device such that the pores are substantially free of webs formed by the coating.

Abstract: A medical device is provided that includes a vessel-engaging member attached to a distal end of a delivery wire. The vessel-engaging member includes a plurality of rows, with each row having a plurality of struts arranged in an alternating pattern such that for each row, a first set of vertices is positioned on a proximal side, and a second set of vertices is positioned on a distal side. The vessel-engaging member further includes a plurality of single bridges positioned between adjacent rows, each of the bridges connecting a vertex of a first row with a corresponding vertex of an adjacent second row. The vessel-engaging member can also include a plurality of double bridges positioned between adjacent rows, each of the double bridges connecting a vertex of a first row with two adjacent vertices of an adjacent second row.

Abstract: A medical device is provided. The medical device includes a vessel-engaging member attached to a distal end of a delivery wire via a connection mechanism. The vessel-engaging member includes a plurality of rows and a plurality of bridges positioned between each adjacent row, each of the bridges connecting a vertex of a first row with a corresponding vertex of a second row. The vessel-engaging member further includes first and second tapered sections coupled to the connection mechanism, each of the tapered sections projecting from a proximal row and tapering in a direction from the proximal row toward the connection mechanism, each of the tapered sections having a length measured along a longitudinal axis, wherein the length of the first tapered section is less than the length of the second tapered section.

Abstract: Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

Abstract: A medical device is provided. The medical device includes a vessel-engaging member attached to a distal end of a delivery wire via a connection mechanism. The vessel-engaging member includes a plurality of rows and a plurality of bridges positioned between each adjacent row, each of the bridges connecting a vertex of a first row with a corresponding vertex of a second row. The vessel-engaging member further includes first and second tapered sections coupled to the connection mechanism, each of the tapered sections projecting from a proximal row and tapering in a direction from the proximal row toward the connection mechanism, each of the tapered sections having a length measured along a longitudinal axis, wherein the length of the first tapered section is less than the length of the second tapered section.

Abstract: Coating methods and related devices are provided. Such devices can include stents. For example, the device can comprise a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can also comprise an anti-thrombogenic coating distributed over at least a portion of the device such that the pores are substantially free of webs formed by the coating.

Abstract: Described herein are vascular remodeling devices that include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchors the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Abstract: Coating methods and related devices are provided. Such devices can include stents. For example, the device can comprise a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can also comprise an anti-thrombogenic coating distributed over at least a portion of the device such that the pores are substantially free of webs formed by the coating.