Abstract: The present disclosure relates to, among others, a composition comprising an internalization peptide, also called a cellular uptake peptide, connected to a drug product, also called a therapeutic payload, by a linker.

Abstract: An intervertebral scaffolding system is provided having an expandable frame operable for a reversible collapse from an expanded state into a collapsed state, the expandable frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the expandable frame and both the stabilizer and the one or more tensioners are configured for retaining the expandable frame from a lateral movement that exceeds the expanded state, and the stabilizer can include a locking element that engages with the expansion member to lock the expansion member to the stabilizer when the expansion member is fully inserted into the frame. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.

Abstract: A superconductor device includes a high superconductivity transition temperature enhanced from the raw material transition temperature. The superconductor device includes a matrix material and a core material. The enhancing matrix material and the core material together create a system of strongly coupled carriers. A plurality of low-dimensional conductive features can be embedded in the matrix. The low-dimensional conductive features (e.g., nanowires or nanoparticles) can be conductors or superconductors. An interaction between electrons of the low-dimensional conductive features and the enhancing matrix material can promote excitations that increase a superconductivity transition temperature of the superconductor device.

Abstract: The present disclosure relates to a fluid dispensing device (10), the fluid dispensing device (1) comprising: a housing (10) to accommodate a container (110) filled with a fluid, wherein the housing (10) comprises a sidewall 118) extending along a longitudinal direction (z), —an outlet orifice (3), —a discharge mechanism (130) operable for spray discharging at least one or multiple doses of the fluid via the outlet orifice (3), —a protective cap (12) pivotally supported on or by the housing (10) between an open position and a closed position, wherein when in the closed position the outlet orifice (3) is effectively covered by the protective cap (12), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a biasing mechanism (150) comprising a biasing member (160) operationally coupled to the prote

Abstract: The present disclosure relates to a fluid dispensing device (1) comprising: —a housing (10) to accommodate a container (110) filled a fluid, —a outlet orifice (3), —a discharge mechanism (130) operable for spray discharging multiple doses of the fluid via the outlet orifice (3), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a releasable interlock (70) configured to retain the mechanical energy storage (50) in the preloaded state, —a trigger mechanism (90) operationally engageable with the interlock (70) and operable i) to release a first portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a first time and ii) to release at least a second portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a second time

Abstract: The present disclosure relates to a mechanical energy storage for a fluid dispensing device (10), the mechanical energy storage comprising:—a first drive spring (51) extending along a longitudinal direction (z),—the drive spring (51) comprising a first longitudinal end (53) to engage with a housing (10) of the fluid dispensing device (1) and a second longitudinal end (54) opposite to the first longitudinal end (53) to engage with a driver (30) movable relative to the housing (10) along the longitudinal direction (z),—wherein the mechanical energy storage (50) is reversibly transferable into a pre-loaded state by resiliently compressing the first drive spring (51) in the longitudinal direction (z) to thereby induce a resilient deformation of the first drive spring (51) in a first direction (y) transverse to the longitudinal direction (z), and-wherein the mechanical energy storage (50) is transferable from the pre-loaded state into an unloaded state by allowing the first drive spring (51) to relax into or towar

Abstract: In one embodiment, the present disclosure is directed to a method for producing a product. For each sample chemical composition of sample chemical compositions, the method inputs into a first model chemoinformatic properties of ingredients of the sample chemical composition, and a value of a property of the sample chemical composition. A new chemical composition is determined via the first model based thereon. The method inputs into a second model, for each sample product of sample products, a value for one or more visual properties of a packaging of the sample product, and one or more characteristics of the new chemical composition. A value is determined for each of the visual properties via the second model. A new product is produced comprising the new chemical composition and packaging comprising the values.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

Abstract: A system, apparatus, and/or method is disclosed for—inter alia—producing a product. One or more financial characteristics relating to one or more sample products may be received. For each of the sample products, a value for each of one or more respective properties of the sample product may be received. The received values of the one or more respective properties of the sample products, the one or more received financial characteristics relating to the sample products, and a desired financial characteristic for a potential product may be input into the machine learning model. A value for each of the one or more respective properties for the potential product may be determined based on the desired financial characteristic for the potential product. A product having the determined value for each of the one or more respective properties for the potential product may be produced.

Abstract: A system, apparatus, and/or method is disclosed for—inter alia—producing a product. One or more financial characteristics relating to one or more sample products may be received. For each of the sample products, a value for each of one or more respective properties of the sample product may be received. The received values of the one or more respective properties of the sample products, the one or more received financial characteristics relating to the sample products, and a desired financial characteristic for a potential product may be input into the machine learning model. A value for each of the one or more respective properties for the potential product may be determined based on the desired financial characteristic for the potential product. A product having the determined value for each of the one or more respective properties for the potential product may be produced.

Abstract: Systems and methods accessing remote digital data over a wide area network (WAN) are disclosed. In an embodiment, a network device is disclosed. The network device includes a local area network (LAN) switching fabric physical interface configured to communicate according to a LAN switching fabric protocol, a WAN physical interface configured to communicate according to a WAN protocol, and a fabric extension function configured to map LAN switching fabric interfaces to pseudo-ports, map pseudo-ports to WAN interfaces, and transmit LAN fabric datagrams received at the LAN switching fabric physical interface from the WAN physical interface via a mapped pseudo-port and a corresponding WAN interface.

Abstract: Embodiments of the present invention are directed to a method, system and apparatus for causing a communication client to join a media-over-packet communication session. The method comprises receiving from a communication client an indication indicative of a desire of the communication client to establish a communication session, the communication client being registered in association with a user account. The method further comprises determining if there exists at least one active communication session established with at least one other communication client registered in association with the user account. Responsive to determining that there does exist at least one active communication session, the method further comprises causing the communication client to join at least one of the at least one active communication session.

Abstract: A method and system implemented by a network entity. The method comprising accessing communication routing information associated to a party. The communication routing information being indicative of at least a first termination device to which incoming communications for the party are to be routed. The method further comprises monitoring at least one of location information, presence information and behavior information associated to the party and processing the communication routing information and the at least one of the location information, presence information and behavior information at least in part on the basis of modification information in an attempt to determine the suitability of modifying the communication routing information. When it is determined that the communication routing information is suitable for modification, causing the party to be advised.

Abstract: A method for effecting communications, such as telephone calls, accesses to data network sites, alarm system communications, and/or other communications, over a communications network. The method comprises: determining that an ability of first end-user equipment at a first end-user premise to communicate via a first communication link connecting the first end-user equipment to the communications network is disrupted; establishing a wireless communication link between the first end-user equipment and second end-user equipment at a second end-user premise; and causing information transmitted by or destined for the first end-user equipment to be exchanged over the communications network via the wireless communication link and a second communication link connecting the second end-user equipment to the communications network. Also provided are apparatus and computer-readable media containing a program element executable by a computing system to perform such a method.

Abstract: In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.

Abstract: A microlayer is provided having a pigment that may include carbon black particles ranging from about 25 nm to about 200 nm in diameter and/or titanium dioxide (Ti02) particles ranging from about 54 nm to about 390 nm in diameter. Such a microlayer may be used in a film that has a core layer adjacent to a substrate layer, which is itself adjacent to an outer layer. The core layer may one or more first multilayers having at least one of carbon black particles ranging from about 25 nm to about 200 nm in diameter and Ti02 particles ranging from about 54 nm to about 390 nm in diameter. Such a film is characterized by an opacity of at least about 90%. A multilayer core layer will result in a film having an Elmendorff tear strength of at least about 27.9 g.

Abstract: A recording head includes a substrate, a read transducer, a waveguide core, and a near-field transducer at an end of the waveguide core proximate a media-facing surface. The recording head includes a magnetic write pole and coil. A laser diode unit with one or more non-self-supporting layers of crystalline material region is transfer printed between layers of the recording head.

Abstract: A recording head includes a substrate, a read transducer, a waveguide core, and a near-field transducer at an end of the waveguide core proximate a media-facing surface. The recording head includes a magnetic write pole and coil. A laser diode unit with one or more non-self-supporting layers of crystalline material region is transfer printed between layers of the recording head.