Abstract: A syringe comprising a syringe barrel having a distal end, a distal tip, a proximal end, a barrel sidewall extending between the distal end to the proximal end and defining a chamber, the barrel sidewall having a barrel sidewall thickness t, the distal end of the syringe barrel including a distal wall is disclosed. The syringe includes a connector extending from the syringe barrel including a collar disposed coaxially around an elongate tip in fluid communication with the barrel to form a channel between the elongate tip and the collar, including an inside surface, an outside surface and a plurality of ribs extending radially outwardly from the outside surface and separated by spaces, each of the plurality of ribs having a height H and a width W, wherein there is a ratio of the height H to the barrel sidewall thickness tin a range of 0.75 and 1.

Abstract: The invention provides methods and compositions for preventing or treating (e.g., slowing the progression of, arresting, and/or reversing) tissue calcification in a subject in need thereof and, more particularly, the invention relates to methods of using menaquinone-7 (MK-7) and/or menaquinol-7 (MKH2-7) for preventing or treating (e.g., slowing the progression of, arresting, and/or reversing) tissue calcification in a subject with diabetes, chronic kidney disease, end stage renal failure, or a subject undergoing hemodialysis and/or receiving anticoagulant therapy. The invention further provides methods and compositions for reducing one or more symptoms of chronic obstructive pulmonary disorder (COPD), including using menaquinone-7 (MK-7) and/or menaquinol-7 (MKH2-7), for preventing or treating (e.g., slowing the progression of, arresting, and/or reversing) one or more symptoms of COPD.

Abstract: The present disclosure encompasses combinations of ralinepag with a cGMP-elevating agent or prostanoid such as riociguat, treprostinil, or iloprost for treating PAH. The disclosed combination therapy provides for advantages such as improved efficacy, improved safety, reduced doses and/or frequency of ralinepag and/or riociguat, reduced doses and/or frequency of ralinepag and/or treprostinil, and reduced doses and/or frequency of ralinepag and/or iloprost. In some embodiments, the clinical effectiveness of a reduced dose combination is additive or synergistic compared to that provided by the corresponding ralinepag, riociguat, treprostinil, and/or iloprost monotherapies.

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

Abstract: A medical device used for grasping a body tissue has a main body having a first arm rotatably connected to a second arm at a pivot point. The main body has a proximal end and a distal end. A handle portion and a locking portion are disposed at the proximal end of the main body. A gripping portion including at least one flexible member is disposed at a distal end of the main body. The at least one flexible member is one of a flexible silicone band and a first gel-filled silicone pad and a second gel-filled silicone pad.

Abstract: Embodiments of the invention comprise a garment; a first design comprising fluorescent material placed on the garment, wherein the first design is externally visible when the garment is worn by a wearer; a second design comprising reflective material overlaid on the first design to create a resulting design, wherein the resulting design provides 360 degree external visibility of the wearer when the garment is worn by the wearer; and wherein the resulting design is an artistic expression. Other embodiments comprise the steps of: creating a design, wherein the design is an artistic expression and comprises a first partial design and a second partial design; transferring the first partial design to a garment comprised of clothing fabric using a fluorescent material; and transferring the second partial design to the garment using a reflective material, wherein all the materials cause a wearer of the garment to have 360 degree external visibility.

Abstract: An automated process for separating and recycling a broad mix of waste material including, but not limited to, paper and flexible plastics. A materials recovery facility (MRF) collects, presorts, and separates into individual commodities the material, then separates partially processed 2D blends from 3D containers, while refraining from any quality control of the 2D blends, and bales the 2D blends. A fiber center receives the bales from the MRF, aggregates the partially processed 2D blends, removes recyclable commodities including flexible plastics from the 2D blends, aggregates each recyclable commodity that is removed from the 2D blends, and forms separate commodity streams of clean paper and clean flexible plastics. Also provided are a related fiber center (and an infrastructure including the center) and at least one computer-readable non-transitory storage medium embodying software for performing the process.

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating diseases or disorders in a subject where the subject is in need of an inhibitor of MEK where the compound is according to formula (I): where R1, R2, R2a, R3, R3a, R3b, and subscript n are as described herein.

Abstract: Isoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Abstract: Microelectromechanical system (MEMS) devices, methods of operating the MEMS device, and methods of manufacturing the MEMS device are disclosed. In some embodiments, the MEMS device includes a glass substrate; an electrode on the glass substrate; a hinge mechanically coupled to the electrode; a membrane mirror mechanically coupled to the hinge; a TFT on the glass substrate and electrically coupled to the electrode; and a control circuit comprising: a multiplexer configured to turn on or turn off the TFT; and a drive source configured to provide a drive signal for charging the electrode through the TFT. An amplitude of the drive signal corresponds to an amount of charge, and the amount of charge generates an electrostatic force for actuating the hinge and a portion of the membrane mirror mechanically coupled to the hinge. In some embodiments, the MEMS devices comprise a charge transfer circuit for providing the amount of charge.

Abstract: A curable coating composition is provided having multi-functionalized acrylic copolymer and amino-functional silicone resin curing agents. The acrylic copolymer of the curable coating composition has, in polymerized form, epoxy functionalized groups and cure compatibility groups and the amino-functional silicone resin is an alkoxy functional siloxane, which optionally is derived from sterically hindered alcohol-amine precursor moieties. The coating compositions are useful in the field of superior weatherable and durable coatings and are useful to replace isocyanate-containing polyurethane based coatings. Also provided are coated articles produced from the curable composition.

Abstract: A method includes extracting multiple shallow features from a low-resolution image using a shallow feature extractor that includes a quaternion convolutional network. The method also includes extracting multiple deep features from the multiple shallow features using a deep feature extractor that includes multiple quaternion residual distillation blocks (QRDBs), where each QRDB includes a quaternion self-attention module. The method further includes reconstructing the multiple deep features into a high-resolution image. Each QRDB may further include a quaternion gated deconvolutional feed forward network (QGDFN) configured to suppress one or more of the multiple deep features.

Abstract: A system and method for hardening security within a physical location. At least one cable in the physical location is monitored for errors. In response to detecting an error on the cable a cable fault analysis procedure is performed to determine the location of the fault on the cable. A probability that the fault is caused by a threat actor is calculated based upon the location of the fault on the cable. The probability can be calculated using mixture modules of known nonthreat locations using supervised learning approaches. At least one security protocol at the physical location is implemented in response to the location of the fault having a probability that the fault location is related to a threat actor exceeding a threshold value.

Abstract: Various embodiments of a system for linear unmixing of spectral images using a dispersion model are disclosed herein.

Abstract: Methods of sensor readout and calibration and circuits for performing the methods are disclosed. In some embodiments, the methods include driving an active sensor at a voltage. In some embodiments, the methods include use of a calibration sensor, and the circuits include the calibration sensor. In some embodiments, the methods include use of a calibration current source and circuits include the calibration current source. In some embodiments, a sensor circuit includes a Sigma-Delta ADC. In some embodiments, a column of sensors is readout using first and second readout circuits during a same row time.

Abstract: Disclosed herein is a sensors-as-a-service ecosystem. In use, the system includes functions for receiving first sensor data at a sensors as a service platform, where the first sensor data corresponds to a first level of capabilities for a first sensor. The system also receives a selection of a sensor upgrade for the first sensor and provisions enhanced sensor capabilities for the sensor upgrade based on the selection. Furthermore, the system sends a sensor update with the enhanced sensor capabilities from the sensors as a service platform to the first sensor. Finally, the system receives second sensor data from the first sensor at the sensors as a service platform, where the second sensor data corresponds to a second level of capabilities for the first sensor.

Abstract: Some implementations involve obtaining a plurality of echo references, the plurality of echo references including at least one echo reference for each audio device of a plurality of audio devices in an audio environment, each echo reference corresponding to audio data being played back by one or more loudspeakers of one audio device of the plurality of audio devices. Some examples involve making an importance estimation for each echo reference of the plurality of echo references. Making the importance estimation may involve determining an expected contribution of each echo reference to mitigation of echo by at least one echo management system of at least one audio device of the audio environment. Some implementations involve selecting, based at least in part on the importance estimation, one or more selected echo references and providing the one or more selected echo references to the at least one echo management system.

Abstract: A method and apparatus are described for a low cost machine-type-communication (LC-MTC) wireless transmit/receive unit (WTRU) to enhance coverage. An example method for physical broadcast channel (PBCH) enhancement includes receiving system information on an enhanced PBCH (ePBCH). The ePBCH is located in a set of radio frames which is a subset of available radio frames, where the subset includes fewer than all the available radio frames. The ePBCH is received in at least one radio frame of the set of radio frames. An example method for physical random access channel (PRACH) enhancement includes receiving configuration of legacy PRACH resources and enhanced PRACH (ePRACH) resources. The WTRU selects one of legacy PRACH resources or ePRACH resources based on a coverage capability. Another example method for PRACH enhancement includes receiving configuration of ePRACH resources. The ePRACH resources include multiple ePRACH resource types, each ePRACH resource type being associated with a coverage capability.

Abstract: Various implementations disclosed herein include devices, systems, and methods for implementing a starter system that utilizes multiple starter solenoids physically isolated from each other. For example, the system may include a first solenoid mechanically connected to a starter motor. The first solenoid may be configured to receive a first starting current signal and mechanically couple the starter motor with an engine. The system may further include a second solenoid mounted within an explosion proof structure physically isolating the second solenoid from the first solenoid and the starter motor. The system may further include a non-incendive circuit mounted within the explosion proof structure. The non-incendive circuit may be configured to indicate that the starter motor is coupled with the engine and signal the second solenoid for activation to supply a cranking current signal to windings of the starter motor for operation.