Abstract: Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat neurocognitive disorders (e.g., Alzheimer's disease, Parkinson's disease), ADHD, Epilepsy, Autism, Sleep-wake disorders, Chronic pain, Inflammatory Disorders, IBD, Stroke, ALS, and/or Multiple Sclerosis.

Abstract: A locker includes a pair of spaced-apart upstanding sidewalls and at least one compartment defined between the upstanding sidewalls. A horizontal member extends at least partially between the sidewalls. An inductive charger is carried by the horizontal member and located such that an electronic device placed on the horizontal member may be charged by the charger. A visible indicia is disposed on the horizontal member indicating the location of the inductive charger; and an illuminated indicia is disposed on the horizontal member to indicate charging of the device.

Abstract: A walk-behind mower has a mower deck, a plurality of wheels, a head, and a plurality of light sources. The wheels are rotatably coupled to the mower deck. The wheels move the walk-behind mower over a support surface in a forward direction and a rearward direction. The head is coupled to the mower deck. The head can store at least one battery pack. The light sources are coupled to at least one of the mower deck and the head. The light sources project light through a continuous illumination angle about the walk-behind mower. The illumination angle extends along an arc from the forward direction toward the rearward direction and is at least 90 degrees.

Abstract: A method of forming an integrated circuit includes forming at least a first or a second set of devices in a substrate, forming an interconnect structure over the first or second set of devices, and depositing a set of conductive structures on the interconnect structure. The first and second set of devices are configured to operate on a first supply voltage. Forming the interconnect structure includes depositing a set of insulating layers over the first or second set of devices, etching the set of insulating layers thereby forming a set of trenches, depositing a conductive material within the set of trenches, thereby forming a set of metal layers, and forming a portion of a header circuit between a first and a second metal layer. The header circuit is configured to provide the first supply voltage to the first set of devices.

Abstract: In an induction system for use with an object processing system, a distribution system is disclosed for providing dissimilar objects into one of a plurality of receiving units. The distribution system includes a conveyor section that travels over a vacuum roller, and the plurality of receiving units arranged generally below the vacuum roller such that an object with a mass will fall toward one of the plurality of receiving units based on both the object's mass and a vacuum force applied to the object through the conveyor section.

Abstract: A video wall and system is disclosed having a computer with a memory or access to a public or private cloud containing a video file and a processor for executing the video file and a plurality of light emitting diode (LED) tiles interconnected to one another and to the computer via wired or wireless transmission, each of the plurality of LED tiles configured to work together to display a video content generated from the video file that extends across all of the plurality of LED tiles. Upon user interaction or detection of a user, one or more of the plurality of LED tiles seamlessly transitions away from the video content to display a separate video content for interaction with the user.

Abstract: A speech processing system includes an input for receiving an input utterance spoken by a user and a word alignment unit configured to align different sequences of acoustic speech models with the input utterance spoken by the user. Each different sequence of acoustic speech models corresponds to a different possible utterance that a user might make. The system identifies any parts of a read prompt text that the user skipped; any parts of the read prompt text that the user repeated; and any speech sounds that the user inserted between words of the read prompt text. The information from the word alignment unit can be used to assess the proficiency and/or fluency of the user's speech.

Abstract: The present disclosure relates to a question recommendation system that intelligently optimizes a survey being created by a user by providing customized suggestions. For example, in one or more embodiments, the question recommendation system provides a suggested question based on questions previous added by a user while creating a survey. In particular, the question recommendation system provides various recommendations to the user to further optimize a survey being created. For instance, the question recommendation system provides recommendations with respect to improving question ordering, question phrasing, and question type as well as recommends removing potentially inefficient questions.

Abstract: Methods and systems for measuring physical properties of a specimen by iterative solution of an optimization function including both current and prior measurement information are described herein. In one aspect, a Maximum A Posteriori (MAP) estimation approach is employed to integrate prior measurement information with current measurement information in the optimization function. In some examples, prior measurement information associated with the measurement of a semiconductor structure is available from a number of exogenous sources. In a further aspect, prior measurement information includes current measurements of a semiconductor structure under measurement as part of a multiple pass measurement. Prior statistics are determined based on an initial set of values of parameters of interest. The prior statistics are included in a subsequent MAP analysis of the same measurement data set employed in a first measurement pass.

Abstract: An open hole formation surface within a wellbore of a well system is sealed with a polymer seal. A deployment system is inserted into the wellbore to the location of the open hole formation surface. The open hole formation surface may be located at the bottom of the wellbore or at an interval between two casing strings. The deployment system delivers an expandable polymer grout system to the location of the open hole formation surface. The expandable polymer grout system cures to form the polymer seal on the open hole formation surface.

Abstract: Systems and methods for mobile offshore carbon capture and sequestration operations. One system includes a first floating offshore installation featuring a direct air capture (DAC) unit, carbon dioxide dehydration unit, CO2 compression unit, and transfer system, and a second floating offshore installation featuring carbon dioxide injection facilities to inject carbon dioxide into an underground reservoir. In other systems and methods, a subsea system is substituted for the second floating offshore installation.

Abstract: A drone detection, identification and location system and method may illuminate a target with one or multiple selected radio-frequency (RF) carrier frequencies. Both direct emissions received from the target and re-emissions generated by the target may be processed to determine whether the target is a drone. The re-emissions may be generated by circuitry of the target resulting from the illumination with the one or multiple RF carrier frequencies. The re-emissions may comprise cross-modulation products (CMPs) including forced non-linear emissions (FNLEs). The direct emissions and the re-emissions may be processed to generate an RF signature for the target. The target may be determined to be drone and the type of drone may be identified based on the RF signature.

Abstract: A machine includes an engine that includes a plurality of cylinders, one or more controllers, and a monitoring and reporting module. The monitoring and reporting module receives, from the one or more controllers, and via a first data link of the machine, cylinder pressure data associated with the plurality of cylinders and stores the cylinder pressure data in a data structure. The monitoring and reporting module receives, from the one or more controllers, and via a second data link of the machine, operational information associated with the engine and determines, based on the operational information, that one or more trigger criteria are satisfied. The monitoring and reporting module generates, based on determining that the one or more trigger criteria are satisfied, a data file that includes a portion of the cylinder pressure data and transmits the data file to a device not included in the machine.

Abstract: A system to study various forces acting on an athletic field or an athletic surface caused by the interaction between a shoe and the turf or athletic surface during a simulated impact includes a cart slidably affixed to a rail, an actuator linked to the cart, and a footform affixed to the cart. The footform is configured to mimic a human foot, animal hoof or animal foot. The cart, rail and actuator are arranged to move the cart and attached footform at an angle relative to a substantially horizontal surface to be tested, whereby the footform contacts the surface to be tested at a selected contact angle.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: A layover bracket system is provided for supporting an industrial vehicle in a horizontal position on a floor surface. The layover bracket system includes a base section removably attached to a first portion of the vehicle at a first location, and an extension section removably attached to a second portion of the vehicle at a second location spaced apart in a first direction from the first location. The first direction is parallel to a vertical axis of the vehicle when positioned in an upright position. The extension section is pivotably coupled to the base section.