Abstract: This application provides isolated antibodies, and antigen-binding fragments thereof that specifically bind chemokine receptor 4 (CXCR4). These CXCR4 antibodies, or antigen-binding fragments thereof, have a high affinity for CXCR4, function to effectively block SDF-1 binding to CXCR4, thereby inhibiting forskolin stimulated cAMP with low nM IC50, are less immunogenic compared to their unmodified parent antibodies in a given species (e.g., in a human), and can be used to treat CXCR4-associated disorders while avoiding the adverse side effects associated with the current CXCR4 antagonist therapies.

Abstract: This application provides isolated antibodies (Abs), e.g., monoclonal antibodies (mAbs), that bind specifically to C—C Motif Chemokine Receptor 8 (CCR8), and bispecific antibodies targeting CCR8 and CTLA-4, and methods for treating a cancer in a subject comprising administering to the subject an anti-CCR8 Ab as monotherapy or in combination with an anticancer agent such as an immune checkpoint inhibitor.

Abstract: This application provides isolated antibodies, and antigen-binding fragments thereof, that specifically bind endothelin A receptor (ETAR). These ETAR antibodies, or antigen-binding fragments thereof, have a high affinity for ETAR, function to effectively block ET-1 binding to ETAR, are less immunogenic compared to their unmodified parent antibodies in a given species (e.g., in a human), and can be used to treat ETAR-associated disorders. Importantly, compared to small molecule ETAR antagonists, the antibodies of the present invention have advantages of longer serum half-life, higher target specificity, thereby limiting the risk of off-target toxicity and improving therapeutic window.

Abstract: According to an aspect of the present invention, there is provided a cup, comprising: a bottom; and a sidewall, wherein: the cup is made of silicone; the cup is flexible; and the cup is resistant to force.

Abstract: According to an aspect of the present invention, there is provided a stainless steel water bottle, comprising: a stainless steel body, wherein the stainless steel body is coated in silicone; a stainless steel cap, wherein the stainless steel cap is also coated in silicone to provide a tight seal with the stainless steel body; and an elastic handle.

Abstract: According to an aspect of the present invention, there is provided a cup, comprising: a bottom; and a sidewall, wherein: the cup is made of silicone; the cup is fully transparent; the cup is colorless; the cup is flexible; and the cup is resistant to force.

Abstract: Methods, systems, and apparatus for door knock access control are disclosed. A monitoring system for monitoring a property includes: a proximity sensor located at a door of the property; a microphone that is configured to detect sound within an area near the door and generate audio data that represents the detected sound; and a monitor control unit configured to perform operations including: receiving, from the proximity sensor, proximity data indicating an object positioned within a set proximity to the door; based on receiving the proximity data, activating the microphone; receiving, from the microphone, the audio data; determining that a similarity between the audio data and stored audio data representing a knocking pattern satisfies similarity criteria; and in response to determining that the similarity between the audio data and the stored audio data satisfies similarity criteria, performing a monitoring system action.

Abstract: Embodiments of the present invention disclose techniques for outputting content aware video based on at least one a video application use case. The technique recognizes objects associated with the use case and performs enhancement of the objects based on content-aware rules and composes at least some of the objects in an output frame based on content-aware frame composition templates. Embodiments of the present invention also disclose systems for implementing the above techniques.

Abstract: Methods, systems, and apparatus for door knock access control are disclosed. A monitoring system for monitoring a property includes: a proximity sensor located at a door of the property; a microphone that is configured to detect sound within an area near the door and generate audio data that represents the detected sound; and a monitor control unit configured to perform operations including: receiving, from the proximity sensor, proximity data indicating an object positioned within a set proximity to the door; based on receiving the proximity data, activating the microphone; receiving, from the microphone, the audio data; determining that a similarity between the audio data and stored audio data representing a knocking pattern satisfies similarity criteria; and in response to determining that the similarity between the audio data and the stored audio data satisfies similarity criteria, performing a monitoring system action.

Abstract: Embodiments of the present invention disclose techniques for outputting content aware video based on at least one a video application use case. The technique recognizes objects associated with the use case and performs enhancement of the objects based on content-aware rules, and composes at least some of the objects in an output frame based on on content-aware frame composition templates. Embodiments of the present invention also disclose systems for implementing the above techniques.

Abstract: A semiconductor device includes a first stack of nanowires above a substrate with a first gate structure over, around, and between the first stack of nanowires and a second stack of nanowires above the substrate with a second gate structure over, around, and between the second stack of nanowires. The device also includes a first source/drain region contacting a first number of nanowires of the first nanowire stack and a second source/drain region contacting a second number of nanowires of the second nanowire stack such that the first number and second number of contacted nanowires are different.

Abstract: A semiconductor device includes a first stack of nanowires above a substrate with a first gate structure over, around, and between the first stack of nanowires and a second stack of nanowires above the substrate with a second gate structure over, around, and between the second stack of nanowires. The device also includes a first source/drain region contacting a first number of nanowires of the first nanowire stack and a second source/drain region contacting a second number of nanowires of the second nanowire stack such that the first number and second number of contacted nanowires are different.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying, at a monitoring system, a location of a device panel, the device panel being configured to communicate with a position module of the monitoring system; obtaining, by the position module, location information for a plurality of anchor devices, each anchor device of the plurality of anchor devices being located within a predefined area of a property; determining, by the position module, a respective location of each anchor device within the predefined area based on analysis of the location information for the plurality of anchor devices; and determining, by the position module, a location for a sensor in the predefined area based on the respective location of at least one anchor device.

Abstract: Embodiments of the present invention disclose techniques for outputting content aware video based on at least one a video application use case. The technique recognizes objects associated with the use case and performs enhancement of the objects based on content-aware rules, and composes at least some of the objects in an output frame based on on content-aware frame composition templates. Embodiments of the present invention also disclose systems for implementing the above techniques.

Abstract: A monitoring system that is configured to monitor a property is disclosed. The monitoring system includes a sensor that is configured to generate sensor data that indicates an attribute of the property; a floor sensor that is configured to generate floor sensor data that indicates an amount of pressure applied to a portion of a floor of the property; and a monitor control unit. The monitor control unit is configured to receive, from the sensor, the sensor data; receive, from the floor sensor, the floor sensor data; analyze the sensor data and the floor sensor data; and based on analyzing the sensor data and the floor sensor data, perform a monitoring system action.

Abstract: Embodiments of the present invention disclose techniques for outputting content aware video based on at least one a video application use case. The technique recognizes objects associated with the use case and performs enhancement of the objects based on content-aware rules, and composes at least some of the objects in an output frame based on on content-aware frame composition templates. Embodiments of the present invention also disclose systems for implementing the above techniques.

Abstract: Techniques and systems are described for creating and operating a vibration triangulation network. The network can include vibration sensor devices placed in a building, such as a store or a house, which are able to pinpoint the location of a target, e.g., person, animal, etc., through triangulation. A described technique includes receiving vibration notifications from vibration sensor devices, determining a location of a target within the building based on at least a portion of the vibration notifications and a vibration sensor map associated with the building, and triggering an alarm event based on a detection of the target.

Abstract: The present invention proposes a semiconductor device. The semiconductor device includes a first and a second transistor sets, a fin pattern, a rare earth oxide layer and an insulation layer. The first and a second transistor sets commonly have at the bases thereof a buried oxide layer (BOX), wherein the first transistor set has a rare earth oxide. The fin pattern on the BOX within a first region for the first transistor set and a second region for the second transistor set. The rare earth oxide layer includes the rare earth oxide and is formed on the BOX and the fin pattern in the first region. The insulation layer is formed on the rare earth oxide layer in the first region, the BOX and the fin pattern in the second region.