Abstract: The present disclosure provides a brachytherapy apparatus, system and method that delivers partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a trocar. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes one or more thin-walled tubes, each of said thin-walled tubes being configured to contain one or more radioactive sources, at least one radiation source configured to deliver a prescribed dose of radiation, a whisk adjuster configured to permit adjustment of each of the one or more thin-walled tubes so that the tubes substantially conform to a size of the body cavity; and an expansion element configured to expand outwardly said one or more thin-walled tubes within the cavity so that the thin-walled tubes substantially conform to a shape and/or size of the body cavity.

Abstract: A heat retaining sleeve for raising the cold spot temperature of a fluorescent lamp is comprised of a base end, a distal end, and a sleeve body sized and shaped to fit over the end of a fluorescent lamp or lamps where the lamp's cold spot exists. The sleeve creates a heat retaining air gap between the inner surface of the sleeve body and the lamp end or ends with the cold spot, and has sufficient length to so that, when fitted over the lamp end or ends, the cold spot temperature is elevated to a temperature that increase the lumen output of the fitted fluorescent lamp or lamps.

Abstract: The disclosure provides a gas turbine engine having a plurality of nozzle vanes extending between an inner shroud wall and an outer shroud wall of the engine. Each of the vanes includes a leading edge and at least one cooling protrusion extending upstream from a center of the leading edge. A cooling system is provided that is operable to inject cooling air upstream from the vanes. The disclosure also provides a method of cooling a gas turbine engine. The method includes the steps of supplying cooling air to an engine nozzle upstream of a gas directing vane, and adjusting the flow of the cooling air with a cooling protrusion extending forward from a leading edge center of the vane.

Abstract: A system for delivering ultrasound energy to a treatment section in a vessel is disclosed. The system includes a sheath with a utility lumen and an energy delivery section at least partially constructed from a material which transmits ultrasound energy. The system also includes a drug delivery member having a plurality of drug delivery ports which are positioned adjacent the energy delivery section. The system further includes an elongated body including at least one ultrasound element and configured to be movably positioned within the utility lumen to transmit the ultrasound energy from the ultrasound element through the energy delivery section.

Abstract: A brachytherapy device may include a plurality of rods, each configured to move between a straightened position and a bowed position, the plurality of rods configured to collectively form a shaft while each rod is in the straightened position and to collectively form at least one cage while at least some of the rods are in the bowed position, at least some of the rods having lumens that are configured to receive and hold radioactive material. A brachytherapy device may further include a rotatable mechanism configured to cause at least some of the plurality of rods to move between the straightened position and the bowed position upon rotation of the rotatable mechanism.

Abstract: A method for efficiently and accurately measuring a maximum Vcc calculation or failure rate and lifetime projection for microprocessors and other semiconductor products analytically scales low voltages applied to thinner oxides to thicker oxides. The expanded voltage window that is closer to the use voltage is obtained thereby to provide accurate voltage acceleration factors and max Vce extraction.

Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.

Abstract: The present disclosure provides a brachytherapy apparatus, system and method that delivers partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a trocar. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes one or more thin-walled tubes, each of said thin-walled tubes being configured to contain one or more radioactive sources, at least one radiation source configured to deliver a prescribed dose of radiation, a whisk adjuster configured to permit adjustment of each of the one or more thin-walled tubes so that the tubes substantially conform to a size of the body cavity; and an expansion element configured to expand outwardly said one or more thin-walled tubes within the cavity so that the thin-walled tubes substantially conform to a shape and/or size of the body cavity.

Abstract: The present disclosure provides a brachytherapy apparatus that delivers a low dose, partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a cannula. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes a seed containment device configured to contain a plurality of low-dose radioactive seeds therein. The seed containment device may be one or more thin-walled tubes. The apparatus is further configured to expand so that at least a portion of the seed containment device is positioned against the remaining tissue and the plurality of radioactive seeds are disposed at the perimeter of the seed containment device. Also described are various clamps for the apparatus, and sleeves for adjusting the size of the device to fit a cavity when the apparatus is in use.

Abstract: A lamp heat extractor device for lowering the cold spot temperature of a fluorescent lamp includes a base portion adapted to be attached to a heat conductive portion of the fluorescent lighting fixture proximate the fixture's lamp socket or sockets, and an extended sleeve end portion thermally connected to the base portion by a conductive connector portion. The conductive connector portion positions the extended sleeve portion so that it contacts the cold spot end of the fluorescent lamp or lamps held by the lamp sockets of the fixture to allow heat transfer to the fixture housing to which the heat extractor device is attached. Suitably, the outer surface of the extended sleeve end portion of the heat extractor device can have a plurality of radially extending fins for increasing surface area for heat radiation from the extended sleeve portion, thereby increasing the overall heat extracting efficiency of the device.

Abstract: A system for delivering ultrasound energy to a treatment section in a vessel is disclosed. The system includes a sheath with a utility lumen and an energy delivery section at least partially constructed from a material which transmits ultrasound energy. The system also includes a drug delivery member having a plurality of drug delivery ports which are positioned adjacent the energy delivery section. The system further includes an elongated body including at least one ultrasound element and configured to be movably positioned within the utility lumen to transmit the ultrasound energy from the ultrasound element through the energy delivery section.

Abstract: A printer driver enables a user to determine whether the features that are required to print a specified job are available to a selected network printer. The printer driver queries the selected printer to acquire the current status and other relevant information for each feature that is required to print the job, then provides the results of the query at a user interface. Accordingly, if any of the required features are unavailable to the selected printer, the user can print the job using another printer or take some other appropriate action.

Abstract: The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.

Abstract: The present invention relates to compositions and the prevention and treatment of circulatory conditions. In one embodiment, the present invention contemplates a compositions comprising anti-platelet aggregating activity. In another embodiment, the present invention contemplates methods to prevent or treat vascular or cardiovascular diseases. In another embodiment, the present invention relates to a method to prevent or treat cardiovascular disease by administering a glycerol saccharide derivative, an arylpolyphenol, a saccharide substituted with an arylpolyphenol, or a steroid substituted with an arylpolyphenol capable of reducing platelet aggregation. In one embodiment, the invention relates to a method of using the compounds capable of reducing platelet aggregation in order to prevent the recurrence of a heart attack by administration of the compounds to a subject after the subject has experienced a heart attack.

Abstract: The invention relates to methods for treating type 2 diabetes, obesity, metabolic syndrome and conditions associated with these by administering an AICAR-monophosphate (AICAR-MP) enhancing agent that increases endogenous AICAR-MP levels in a cell. Inhibition of AICAR-formyltransferase activity (AICARFT) in a cell that regulates metabolic activity (such as fat, liver, muscle, pancreatic beta or certain brain cells) increases AICAR-monophosphate levels which in turn results in activation of the AMP-kinase (AMPK) pathway, and all of the downstream functions mediated by AMPK including increased fatty acid oxidation, enhanced glucose transport and decreased fatty acid synthesis.

Abstract: A bio-sensor that includes (a) an optical fiber in which the surface of the fiber comprises a hydrogel polymer that includes a functional group comprising a first member of a binding pair; and (b) an excitation light source coupled to the fiber. When the fiber contacts a solution comprising a second member of the binding pair labeled with a light-emitting label, the first member binds to the second member, resulting in the emission of a detectable signal. Alternatively, the first member of the binding pair is provided with the light-emitting label.

Abstract: The present invention provides self-servo writing by which self-propagated servo pattern track shape errors are reduced or eliminated. The method includes providing first servo bursts on a first track, measuring edge errors of the first servo bursts, and self-servo writing second servo bursts to a second track using different combinations of the edge errors to adjust the position error signals for the second servo bursts.

Abstract: A cutter having a base portion, an ultrahard layer disposed on the base portion, and at least one relief groove formed on an outer surface of the cutter. The at least one relief groove is configured to form a relief gap between the ultrahard layer and an inside surface of a cutter pocket.

Abstract: Drill bit reinforcing members or blanks of this invention are formed from high-strength steels having a carbon content less than about 0.3 percent by weight, a yield strength of at least 55,000 psi, a tensile strength of at least 80,000 psi, a toughness of at least 40 CVN-L, Ft-lb, and a rate of expansion percentage change less than about 0.0025%/° F. during austenitic to ferritic phase transformation. In one embodiment, such steel comprises in the range of from about 0.1 to 0.3 percent by weight carbon, 0.5 to 1.5 percent by weight manganese, up to about 0.8 percent by weight chromium, 0.05 to 4 percent by weight nickel, and 0.02 to 0.8 percent by weight molybdenum. In another example, such steel comprises in the range of from about 0.1 to 0.3 percent by weight carbon, 0.9 to 1.5 percent by weight manganese, 0.1 to 0.5 percent by weight silicon, and one or more microalloying element selected from the group consisting of vanadium, niobium, titanium, zirconium, aluminum and mixtures thereof.

Abstract: A zoned web material having zones of radiation crosslinked elastomeric material with improved elevated temperature properties and lotion resistance. The elastomeric web comprises at least one first zone or region being characterized by a relatively high level of crosslinking and at least one second zone or region being characterized by a relatively low level of crosslinking. The zones of high crosslinking correspond to the zones of improved elastomeric properties, and can be made in virtually any predetermined pattern. In a preferred embodiment, the zoned web material is suitable for use in elasticized or body-hugging portions of disposable absorbent articles such as the side panels, waist bands, or cuffs of disposable diapers, or of health care products such as dressings, bandages and wraps. The zoned web material of the present invention may also be used in other portions of the absorbent articles where a stretchable portion of material is desired, such as stretchable topsheets or backsheets.