Patents by Inventor Joly Sukumaran

Joly Sukumaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20170081685
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Application
    Filed: December 8, 2016
    Publication date: March 23, 2017
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • ENGINEERED BIOCATALYSTS USEFUL FOR CARBAPENEM SYNTHESIS
    Publication number: 20170073654
    Abstract: The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also provides polynucleotides encoding the engineered pNB esterases, host cells capable of expressing the engineered pNB esterases, and methods of using the engineered pNB esterases in the production of imipenem.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Inventors: Joly Sukumaran, Derek Smith, Hong Yang, Wan Lin Yeo, Jeffrey C. Moore
  • ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
    Publication number: 20170022527
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: October 6, 2016
    Publication date: January 26, 2017
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • Variant LovD polypeptides and their uses
    Patent number: 9546388
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: January 17, 2017
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • Engineered biocatalysts useful for carbapenem synthesis
    Patent number: 9540622
    Abstract: The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also provides polynucleotides encoding the engineered pNB esterases, host cells capable of expressing the engineered pNB esterases, and methods of using the engineered pNB esterases in the production of imipenem.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: January 10, 2017
    Assignee: Codexis, Inc.
    Inventors: Joly Sukumaran, Derek Smith, Hong Yang, Wan Lin Yeo, Jeffrey C. Moore
  • Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
    Patent number: 9487760
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: November 8, 2016
    Assignee: Codexis, Inc.
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
    Publication number: 20160304921
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Application
    Filed: June 30, 2016
    Publication date: October 20, 2016
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF
    Publication number: 20160244792
    Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
    Type: Application
    Filed: May 10, 2016
    Publication date: August 25, 2016
    Inventors: Anupam Gohel, Derek J. Smith, Brian Wong, Joly Sukumaran, Wan Lin Yeo, Steven J. Collier, Scott Novick
  • Lov-D acyltransferase mediated acylation
    Patent number: 9399785
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: July 26, 2016
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
    Publication number: 20160168545
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: February 19, 2016
    Publication date: June 16, 2016
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • Biocatalytic process for preparing eslicarbazepine and analogs thereof
    Patent number: 9365878
    Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 14, 2016
    Assignee: Codexis, Inc.
    Inventors: Anupam Gohel, Derek J. Smith, Brian Wong, Joly Sukumaran, Wan Lin Yeo, Steven J. Collier, Scott Novick
  • Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
    Patent number: 9296993
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: March 29, 2016
    Assignee: Codexis, Inc.
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
    Publication number: 20160040140
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: October 20, 2015
    Publication date: February 11, 2016
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • ENGINEERED BIOCATALYSTS USEFUL FOR CARBAPENEM SYNTHESIS
    Publication number: 20150353976
    Abstract: The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also provides polynucleotides encoding the engineered pNB esterases, host cells capable of expressing the engineered pNB esterases, and methods of using the engineered pNB esterases in the production of imipenem.
    Type: Application
    Filed: January 16, 2014
    Publication date: December 10, 2015
    Inventors: Joly Sukumaran, Derek Smith, Hong Yang, Wan Lin Yeo, Jeffrey C. Moore
  • Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
    Patent number: 9193957
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: November 24, 2015
    Assignee: Codexis, Inc.
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt Huisman, Scott Novick, Nicholas Agard, Oscar Alvizo, Gregory Cope, Wan Lin Yeo, Stefanie Ng Minor
  • BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF
    Publication number: 20150329835
    Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 19, 2015
    Inventors: Anupam Gohel, Derek J. Smith, Brian Wong, Joly Sukumaran, Wan Lin Yeo, Steven J. Collier, Scott Novick
  • Variant LovD polypeptides and their uses
    Patent number: 9181570
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: November 10, 2015
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
    Publication number: 20150259718
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Application
    Filed: May 11, 2015
    Publication date: September 17, 2015
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20150240276
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: May 13, 2015
    Publication date: August 27, 2015
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • Biocatalytic process for preparing eslicarbazepine and analogs thereof
    Patent number: 9102963
    Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: August 11, 2015
    Assignee: Codexis, Inc.
    Inventors: Anupam Gohel, Derek Smith, Brian Wong, Joly Sukumaran, Wan Lin Yeo, Steven J. Collier, Scott Novick