Patents by Inventor Joly Sukumaran

Joly Sukumaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lov-D acyltransferase mediated acylation
    Patent number: 9057085
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 16, 2015
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20150037851
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: August 21, 2014
    Publication date: February 5, 2015
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • Variant LOVD polypeptides and their uses
    Patent number: 8846362
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: September 30, 2014
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
  • BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF
    Publication number: 20140199735
    Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
    Type: Application
    Filed: April 12, 2012
    Publication date: July 17, 2014
    Applicant: CODEXIS, INC.
    Inventors: Anupam Gohel, Derek Smith, Brian Wong, Joly Sukumaran, Wan Lin Yeo, Steven J. Collier, Scott Novick
  • Engineered imine reductases and methods for the reductive animation of ketone and amine compounds.
    Publication number: 20130302859
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: May 9, 2013
    Publication date: November 14, 2013
    Applicant: CODEXIS,INC.
    Inventors: CHEN Haibin, Steven J. Collier, Jovana NAZOR, Joly SUKUMARAN, Derek SMITH, Jeffrey C. MOORE, Gregory HUGHES, Jacob JANEY, Gjalt HUISMAN, Scott NOVICK, Nicholas AGARD, Oscar ALVIZO, Gregory COPE, Wan Lin YEO, Stephanie NG
  • Variant LovD polypeptides and their uses
    Patent number: 8383382
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: February 26, 2013
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
  • LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
    Publication number: 20120244582
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Application
    Filed: September 24, 2010
    Publication date: September 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Steven James Collier, Ee Ling Teo, Joly Sukumaran, Robert John Wilson, Junye Xu
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20110111468
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: September 24, 2010
    Publication date: May 12, 2011
    Applicant: Codexis, Inc.
    Inventors: Lynne GILSON, Steven James COLLIER, Joly SUKUMARAN, Wan Lin YEO, Oscar ALVIZO, Ee Ling TEO, Robert John WILSON, Junye XU