Patents by Inventor Jon Thomas

Jon Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11639510
    Abstract: Devices and methods are presented for delivery of various macrostructures into cells, such as depleted cells as well as methods of generating engineered cells using said devices and methods. Cells are placed on a porous membrane. A force is applied by a configurable actuator to a deformable fluid reservoir that generates an applied pressure to macrostructures in a solution, causing the macrostructures to pass through the porous membrane and triggering uptake of at least some of the macrostructures into the cells to form transfected cells. Said devices and methods may be used in a process to replace defective endogenous mtDNA with corrected mtDNA to generate cellular-based therapeutics for administration to a patient. The customizable actuator may be configured with parameters to optimize efficiency for a given cell type and material to be transfected. Machine learning techniques also may be utilized to optimize transfection parameters.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: May 2, 2023
    Assignee: NANOCAV, LLC
    Inventors: Ting-Hsiang Sherry Wu, Artin Mehrabi, Jon Thomas Van Lew
  • Publication number: 20230037741
    Abstract: Disclosed are personal care formulations, personal care methods and personal care devices that comprise or use a gel, lotion, cream or the like comprising (a) one or more active ingredients for providing a beneficial effect to the skin and/or hair and/or mucous membranes of a human and (b) from about 1 percent by weight to about 50 percent by weight of foam forming component(s) comprising trans-1-chloro-3,3,3-trifluoropropene (1233zd(E).
    Type: Application
    Filed: May 21, 2022
    Publication date: February 9, 2023
    Applicant: HONEYWELL INTERNATIONAL INC.
    Inventors: Anthony Anzalone, Jon Thomas Herdlein, Yiu Keung Ling
  • Publication number: 20220277260
    Abstract: Systems and methods for remotely monitoring the amount of fuel in one or more fuel tanks are disclosed. A fuel monitoring device includes a sensor configured to monitor the operation of a valve coupled to an output of a fuel tank and a network and communication system configured to receive data from the sensor related to the operation of the valve and establish communication with one or more remote systems via a communications network. The fuel monitoring device communicates the data related to the operation of the sensor to a remote server system via the communications network. Based on the data received from the fuel monitoring device and one or more remote systems, the remote server system can determine the amount of fuel remaining in the tank, and can predict when the tank will require additional fuel.
    Type: Application
    Filed: March 1, 2021
    Publication date: September 1, 2022
    Applicant: Fivovos, LLC
    Inventors: Charles Jacob Shotmeyer, Jon Thomas Buonaccorsi, Christopher Louis Corrado, Edward Norman McGrath, III
  • Publication number: 20220226226
    Abstract: Disclosed are methods of applying a leave-on personal care treatment products comprising: a) providing a container having a nozzle or opening for selectively releasing the contents thereof: b) including in the container a leave-on personal care formulation comprising: (i) an active component for affecting the personal care of the user; (ii) a carrier for the active component, said carrier comprising at least about 50% by weight of trans-HCFO-1233zd and optionally a co-carrier in amounts of up to about 50% by weight; and c) spraying said leave-on personal care formulation from the container and onto the area of the user to be treated.
    Type: Application
    Filed: February 15, 2022
    Publication date: July 21, 2022
    Applicant: HONEYWELL INTERNATIONAL INC.
    Inventors: Anthony Anzalone, Yiu Keung Ling, Jon Thomas Herdlein, Leonard Michael Stachura
  • Publication number: 20220178117
    Abstract: A liquid dosing system is disclosed and can include a cartridge comprising a reservoir configured to store an additive, an output vessel in fluid communication with the reservoir, and a cartridge outlet in fluid communication with the output vessel. The liquid dosing system can include a housing that includes a water passage configured to direct water though the liquid dosing system and a receiving portion configured to at least partially receive the cartridge when the cartridge is connected to the housing. The receiving portion can include a receiving port in fluid communication with the water passage, and the receiving port can be configured to receive at least some of the additive from the cartridge outlet when the cartridge is connected to the housing. The receiving portion can include a motor configured to engage in mechanical communication with the output vessel when the cartridge is connected to the housing.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 9, 2022
    Inventors: Taylor Leigh, Jason Lye, Atilhan Manay, Stephen Phelps, Troy Trant, Jon Thomas, Prudhvi Amaravadhi, Edward Holman, Fahira Sangare
  • Publication number: 20220177338
    Abstract: A liquid dosing system is disclosed and can include an inlet conduit and an outlet conduit. The inlet and outlet conduits can each be configured to fluidly communicate a heat exchanger of a water heater. The liquid dosing system can include one or more connector conduits configured to fluidly connect the inlet conduit and the outlet conduit to define a fluid circuit by at least the inlet conduit, the heat exchanger, the outlet conduit, and the one or more connector conduits. The liquid dosing system can include a pump configured to pump water through the fluid circuit, a reservoir configured to store an additive, and a dosing device configured to dispense the additive into the fluid circuit.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 9, 2022
    Inventors: Taylor Leigh, Jason Lye, Atilhan Manay, Stephen Phelps, Troy Trant, Jon Thomas, Prudhvi Amaravadhi, Edward Holman, Fahira Sangare
  • Publication number: 20220178362
    Abstract: A peristaltic pump system is disclosed and can include a rigid backing and a rotor assembly comprising a central hub. The central hub can rotate along a central axis extending in an axial direction. The central hub can include one or more ball bearings or one or more rollers that are configured to rotate about a respective roller axis that intersects a central axis of the central hub. Located between the rigid backing and the rotor assembly can be tubing or a flow channel that is defined by the rigid backing and an elastomeric sheet. As the central hub rotates, the one or more rollers or ball bearings are configured to push against the tubing or the flow channel in the axial direction and can move along the tubing or the flow channel to move fluid through the tubing or the flow channel.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 9, 2022
    Inventors: Taylor Leigh, Jason Lye, Atilhan Manay, Stephen Phelps, Troy Trant, Jon Thomas, Prudhvi Amaravadhi, Edward Holman, Fahira Sangare
  • Patent number: 11337904
    Abstract: Disclosed are personal care formulations, personal care methods and personal care devices that comprise or use a gel, lotion, cream or the like comprising (a) one or more active ingredients for providing a beneficial effect to the skin and/or hair and/or mucous membranes of a human and (b) from about 1 percent by weight to about 50 percent by weight of foam forming component(s) comprising trans-1-chloro-3,3,3-trifluoropropene (1233zd(E).
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: May 24, 2022
    Assignee: HONEYWELL INTERNATIONAL INC.
    Inventors: Anthony Anzalone, Jon Thomas Herdlein, Yiu Keung Ling
  • Publication number: 20220025402
    Abstract: An apparatus for electroporating cells with a cargo includes electrodes defining a path for a fluid including the cells and the cargo to flow, a power source coupled across the electrodes, and a control circuit. In some examples, the control circuit is configured to detect a decrease in an induced current due to an increase in a resistance between the electrodes, and control the power source to increase the induced current to maintain an electric field between the electrodes. A future value of the resistance between the electrodes may be predicted based on previous values of the resistance. In other examples, the control circuit is configured to detect parameters of the fluid flowing between the electrodes, and control the power source to generate or stop generating electrical pulses in response to detecting the parameters. Other example apparatuses, and methods of electroporating cells with a cargo is also disclosed.
    Type: Application
    Filed: July 22, 2020
    Publication date: January 27, 2022
    Applicant: NantCell, Inc.
    Inventors: Chih-Wei CHANG, Jon Thomas VAN LEW, Artin MEHRABI
  • Publication number: 20210408863
    Abstract: A pivot motor for a hair clipper is provided, including a stator with a plurality of laminations, a bobbin located in operational relation to the stator and having a coil of wire wound around the bobbin, an armature being configured for driving a hair clipper moving blade at one end, and having at least one magnet at an opposite end, the armature having a pivot point, and the motor being configured for operation between 2.5 and 4.
    Type: Application
    Filed: June 24, 2021
    Publication date: December 30, 2021
    Inventors: David Joseph TODD, Rafi SYED, Curtis James DE FRANG, Stephan BEHA, Dustin R. TAYLOR, Jon Thomas FREAS, Jason Kyle EVERLY, Daniel Adam BLUMHOFF, Matthew USTERBOWSKI, Sudhir BRAHMANDAM, Matthew Jason BOWERS, Scott MELTON, Drew Paul MITCHELL
  • Publication number: 20200377587
    Abstract: Compositions, methods, and uses of recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to IL-8 to target tumor-expressed or endogenous IL-8 are presented. Preferably, the recombinant IL-8 antibody or scFv fragment includes a VH segment comprising a first amino acid sequence selected from SEQ ID NO. 1-15, 31-32, and/or a VL segment comprising a second amino acid sequence selected from SEQ ID NO. 16-30, 33-34. The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.
    Type: Application
    Filed: July 14, 2020
    Publication date: December 3, 2020
    Inventors: Patrick Soon-Shiong, Kayvan Niazi, Shiho Tanaka, Jon Thomas Van Lew, Clifford Anders Olson
  • Publication number: 20200344956
    Abstract: The automated trimming of an untrimmed plant stem comprises a device for transporting an untrimmed plant stem to an imaging stage, using a camera to capture at least one image of the plant stem, sending the at least one image to a central processor which creates a trim map which constructs a pattern for moving a cutting armature along the plant stem, and trimming the plant stem by cutting structure of the cutting armature to change the untrimmed plant stem to a trimmed plant stem.
    Type: Application
    Filed: May 12, 2020
    Publication date: November 5, 2020
    Inventor: Jon Thomas GOWA
  • Patent number: 10752682
    Abstract: Compositions, methods, and uses of recombinant recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to IL-8 to target tumor-expressed or endogenous IL-8 are presented. Preferably, the recombinant IL-8 antibody or scFv fragment includes a VH segment comprising a first amino acid sequence selected from SEQ ID NO. 1-15, 31-32, and/or a VL segment comprising a second amino acid sequence selected from SEQ ID NO. 16-30, 33-34. The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: August 25, 2020
    Assignee: NantBio, Inc.
    Inventors: Patrick Soon-Shiong, Kayvan Niazi, Shiho Tanaka, Jon Thomas Van Lew, Clifford Anders Olson
  • Patent number: 10687476
    Abstract: The automated trimming of an untrimmed plant stem comprises a device for transporting an untrimmed plant stem to an imaging stage, using a camera to capture at least one image of the plant stem, sending the at least one image to a central processor which creates a trim map which constructs a pattern for moving a cutting armature along the plant stem, and trimming the plant stem by cutting structure of the cutting armature to change the untrimmed plant stem to a trimmed plant stem.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: June 23, 2020
    Assignee: Bloom Automation, Inc.
    Inventor: Jon Thomas Gowa
  • Patent number: 10677945
    Abstract: The invention relates to a hydrophone housing. The housing comprises an outer casing with an exterior shape being in close contact with sediment when buried therein and having a deflectable wall part. Solid material partly fills the casing to define an outer chamber behind the deflectable wall part, a cavity shaped so that an inner chamber is defined immediately surrounding a hydrophone sensing element held therein, and a first duct for liquid flow communication between the outer chamber and the cavity or an internal volume of the hydrophone sensing element. Thereby, a hydraulic coupling is provided so that an acoustic pressure causing small radial displacements of outer surface of the housing will, via liquid in the first duct, cause large radial displacements of the hydrophone sensitive element.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: June 9, 2020
    Assignee: OPTOPLAN AS
    Inventors: Roar Furuhaug, Jon Thomas Kringlebotn
  • Publication number: 20200087685
    Abstract: Devices and methods are presented for delivery of various macrostructures into cells, such as depleted cells as well as methods of generating engineered cells using said devices and methods. Cells are placed on a porous membrane. A force is applied by a configurable actuator to a deformable fluid reservoir that generates an applied pressure to macrostructures in a solution, causing the macrostructures to pass through the porous membrane and triggering uptake of at least some of the macrostructures into the cells to form transfected cells. Said devices and methods may be used in a process to replace defective endogenous mtDNA with corrected mtDNA to generate cellular-based therapeutics for administration to a patient. The customizable actuator may be configured with parameters to optimize efficiency for a given cell type and material to be transfected. Machine learning techniques also may be utilized to optimize transfection parameters.
    Type: Application
    Filed: July 19, 2019
    Publication date: March 19, 2020
    Inventors: Ting-Hsiang Sherry WU, Artin MEHRABI, Jon Thomas VAN LEW
  • Publication number: 20200069553
    Abstract: Disclosed are methods of applying a leave-on personal care treatment products comprising: a) providing a container having a nozzle or opening for selectively releasing the contents thereof; b) including in the container a leave-on personal care formulation comprising: (i) an active component for affecting the personal care of the user; (ii) a carrier for the active component, said carrier comprising at least about 50% by weight of trans-HCFO-1233zd and optionally a co-carrier in amounts of up to about 50% by weight; and c) spraying said leave-on personal care formulation from the container and onto the area of the user to be treated.
    Type: Application
    Filed: August 29, 2019
    Publication date: March 5, 2020
    Inventors: Anthony Anzalone, Yiu Keung Ling, Jon Thomas Herdlein, Leonard Michael Stachura
  • Publication number: 20190201301
    Abstract: Disclosed are personal care formulations, personal care methods and personal care devices that comprise or use a gel, lotion, cream or the like comprising (a) one or more active ingredients for providing a beneficial effect to the skin and/or hair and/or mucous membranes of a human and (b) from about 1 percent by weight to about 50 percent by weight of foam forming component(s) comprising trans-1-chloro-3,3,3-trifluoropropene (1233zd(E).
    Type: Application
    Filed: December 21, 2018
    Publication date: July 4, 2019
    Inventors: Anthony Anzalone, Jon Thomas Herdlein, Yiu Keung Ling
  • Publication number: 20190127458
    Abstract: Compositions, methods, and uses of recombinant recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to IL-8 to target tumor-expressed or endogenous IL-8 are presented. Preferably, the recombinant IL-8 antibody or scFv fragment includes a VH segment comprising a first amino acid sequence selected from SEQ ID NO. 1-15, 31-32, and/or a VL segment comprising a second amino acid sequence selected from SEQ ID NO. 16-30, 33-34. The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.
    Type: Application
    Filed: October 29, 2018
    Publication date: May 2, 2019
    Inventors: Patrick SOON-SHIONG, Kayvan NIAZI, Shiho TANAKA, Jon Thomas VAN LEW, Clifford Anders OLSON
  • Patent number: 10094072
    Abstract: A milling system for milling a track surface with at least one rotatable milling plate. A modular blade system for each milling plate allows individual blades to be removed and replaced when an individual blade becomes dull or broken. The blade system also allows the milling plates to be oriented in both Type 2 and Type 3 configurations depending upon track surroundings and the presence of encumbrance. The milling plates can be mounted to a positioning assembly for adjusting the relative distance between the milling plate and the track surface as well as the angle at which the milling plate engages the track surface. The milling system can include a depth guide so as to physically prevent the milling plate from cutting too deeply into the track surface.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: October 9, 2018
    Assignee: Loram Maintenance of Way, Inc.
    Inventor: Jon Thomas Behrens