Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: A location detection system identifies the locations of medical devices such as patient support apparatuses and/or patient care devices within a medical facility. The devices communicate via a wired connection to one or more medical facility systems (e.g. nurse call system, computer network, etc.), and/or via a wireless connection to such systems. The location detection system automatically determines location information of the devices and communicates the location information so that the recipient of any outgoing alerts and/or other information sent from the devices is apprised of the location of the particular device sending the alert or other information. Caregivers are thereby able to respond to the correct location of an alert, and software systems such as EMR systems, admission discharge and transfer (ADT) systems, etc. are able to correlate transmitted device data with the location and/or patient assigned to that location.

Abstract: A person support apparatus, such as a bed, stretcher, cot, recliner, or the like, includes a support surface adapted to support a person, a litter, an accelerometer positioned below the support surface, and a controller that processes signals from the accelerometer to detect the presence or absence of a person on the support surface. In some embodiments, the controller also receives signals from a plurality of force sensors and uses them in combination with the accelerometer outputs to determine if the person has exited the person support apparatus. The controller may also be adapted to use outputs from the accelerometer to detect an impact against the person support apparatus, compare a magnitude of the detected impact with a threshold, and, if the threshold is exceeded, to issue a warning indicating potential damage to one or more of the plurality of force sensors.

Abstract: Memory systems that include NAND flash memory and dynamic random access memory (DRAM) are configured to allow a considerably higher ratio of NAND to DRAM without a significant increase in write amplitude. The NAND includes a logical-to-physical (L2P) table. The DRAM includes a buffer divided into regions, an update table of recently written data and linked lists, one for each region of the buffer linking all items in the update table in that region, the DRAM maintaining a set of linked lists, each identifying all regions with the same number of updates in the update table.

Abstract: A temperature regulating carrier to create ambient environment to negate negative effects of thermal environmental factors. The carrier is suitable for backpacking and other outdoor activities and can easily fit inside of a backpack or be clipped onto a harness, sled, or any other object. The carrier is formed of a multi-layer thermal blanket material having an outer fabric layer, an inner liner, and a thermal insulation layer formed of a synthetic amorphous silica on a non-woven, needled batting that is disposed between the outer fabric layer and the inner liner to provide a thermally insulated interior chamber.

Abstract: A method for validating data changes made to a database is disclosed. The changes are made in the context of a transaction, and validation is performed using a rules database storing a plurality of rules. The method includes identifying a set of data entities affected by one or more data changes made in the context of the transaction. In response to an instruction to commit the transaction, data entities in the set of affected data entities are validated using rules from the rules database. The transaction is committed in dependence on the outcome of the validation.

Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: Techniques and systems for completing a database query. A time to complete a synchronous query in response to receiving an original database query is estimated by a database management system provided by one or more computing devices. A synchronous database query corresponding to the original database query is performed with the database management system if the estimated time to complete the synchronous query is less than a pre-selected threshold time. One or more asynchronous queries corresponding to the original database query are performed with the database management system if the estimated time to complete the synchronous query is greater than the pre-selected threshold time. A result, whether from a synchronous query or one or more asynchronous queries, is stored in an object within a non-relational database system.

Abstract: A patient support apparatus includes a plurality of primary sensors adapted to measure different parameters used in the control of the patient support apparatus. One or more suites of secondary sensors are added to the patient support apparatus to provide data about the primary sensors. The secondary sensors may be used to detect errors in the primary sensors, to modify outputs from the primary sensors, and/or to provide usage and/or diagnostic data about the use of the patient support apparatus. The suite(s) of secondary sensors may measure parameters that affect the outputs of one or more of the primary sensors. In some embodiments, the suite(s) of secondary sensors include one or more dormant sensors that are not used on the patient support apparatus until a code modification is received from one or more external sources instructing the control system of the patient support apparatus to begin using the dormant sensor(s).

Abstract: Methods for amplifying nucleic acids are provided. The methods can be used to minimize sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimizing GC bias during amplification reactions with multiple templates of different sequence. The methods are suited to solid phase amplification, for example, utilizing flow cells.

Abstract: A person support apparatus, such as a bed, cot, stretcher, or the like, includes an exit detection system that utilizes an occupant motion parameter to determine whether to issue an alert or not. The motion parameter may be based on the weight and motion of the occupant. Successive positions of the occupant are determined in order to calculate a velocity of the occupant. In some embodiments, the kinetic energy of the occupant is used to determine if an alert should be issued. Objects positioned on the person support apparatus may also be detected and tracked. Auto-zeroing of a built-in scale, as well as automatic recognition of the removal, movement, and/or addition of objects is also provided.

Abstract: Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules.

Abstract: First communication information is received from a first communication session in a first communication medium. The first information has an associated first topic identifier. The first communication information may be a media stream, such as a voice media stream. Second communication information is received from a second communication session in a second communication medium associated with the first topic identifier. The first and second communication mediums are different communication mediums. The second communication session occurs after the first communication session has ended. For example, the second communication medium may be an email that occurs after a voice call has completed. The first information and the second information are stored in a first topic record based on the first topic identifier. A user can then access the topic record to view the first and second communication information for the topic.

Abstract: A system and method for processing fractional share sales transactions wherein a user electronically interfaces with a computing device including software for collecting personal, contact and payment information from users, offering fractional shares of a lot for sale, creating fractional share purchase orders, collecting payment for the fractional share purchase orders and aggregating fractional share purchase orders to equal a whole lot. Once a complete or whole lot is so aggregated the system and method operate to purchase the lot comprising the fractional shares. Following purchase, the system and method distribute fractional shares of the lot to the fractional share purchasers. In one embodiment the system and method are configured to permit and facilitate users with trading or selling portions of their allocated or selected fractional share of the lot with other users of the system.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: The invention provides methods for amplifying nucleic acids, particularly methods for reducing density-dependent GC bias and for reducing nucleic acid damage in a bridge amplification of a nucleic acid template. The invention also provides methods for evaluating the effect of reagents and/or additives on nucleic acid damage during bridge amplification of nucleic acid template strands. The methods are suited to solid phase amplification, for example, utilizing flow cells.

Abstract: A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated.

Abstract: Disclosed herein are compositions and methods for sequencing nucleic acids.

Abstract: Techniques and systems for completing a database query. A time to complete a synchronous query in response to receiving an original database query is estimated by a database management system provided by one or more computing devices. A synchronous database query corresponding to the original database query is performed with the database management system if the estimated time to complete the synchronous query is less than a pre-selected threshold time. One or more asynchronous queries corresponding to the original database query are performed with the database management system if the estimated time to complete the synchronous query is greater than the pre-selected threshold time. A result, whether from a synchronous query or one or more asynchronous queries, is stored in an object within a non-relational database system.