Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to sequences of electronic messages to drive user engagement. For example, a method may include determining a set of messages including at least a first message and a second message; transmitting the first and second messages as an initial message to a first plurality of devices and a second plurality of devices, respectively; determining a first and second performance indicator at least based on one or more responses to the first and second messages transmitted as the initial message, respectively; comparing the first performance indicator and the second performance indicator; and sorting a sequence of the set of messages based on the comparison of the first performance indicator to the second performance indicator.

Abstract: A patient support apparatus is provided, such as a bed, cot, stretcher, or the like, that includes a sensor adapted to detect movement of the occupant while the occupant is supported on the support apparatus. A controller monitors outputs from the sensor in response to a mobility assessment control being activated. After monitoring the outputs for a period of time, the controller generates a mobility score based on the outputs from the sensor. In some embodiments, the controller use outputs from the sensor to determine which region of a defined surface area the patient has moved to. The controller records these visited regions over a time period and uses them to generate the mobility assessment. The mobility assessment provides an objective measure of an important factor used in predicting a patient's risk of developing pressure ulcers.

Abstract: Presented herein are methods and compositions for concatenating template strands during the bridge amplification process. The methods are useful for surface amplification at improved densities. The methods and compositions provided herein enable creation of clusters that are brighter, but at the same densities as currently achieved using standard cluster amplification.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to email journeys. For example, a method may include determining a first development subset, a first quality assurance subset, and a first production subset of a first plurality of user identifiers; determining and transmitting a first development set of messages, a first quality assurance set of messages, and a first production set of message; determining a development performance indicator, a quality assurance performance indicator, and a production performance indicator based on one or more messages received in response to the transmitted first development set of messages, first quality assurance set of messages, and first production set of message, respectively.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: A closed loop control system for controlling a plant comprises a controller includes an input arranged to receive a feedback signal from the plant. The controller is arranged to compare a value of the feedback signal to a set point value x(s) and to produce an error signal c(s) that is at least partially dependent on a difference between the value of the feedback signal and the set point value. The controller also includes an output arranged to supply the error signal c(s) to the plant. A monitor is arranged to compare a value of the error signal c(s) produced by the controller to a threshold value and to produce a warning signal when the value of the error signal c(s) exceeds the threshold value for a period of time greater than a predetermined period.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: Memory systems that include NAND flash memory and dynamic random access memory (DRAM) are configured to allow a considerably higher ratio of NAND to DRAM without a significant increase in write amplitude. The NAND includes a logical-to-physical (L2P) table. The DRAM includes a buffer divided into regions, an update table of recently written data and linked lists, one for each region of the buffer linking all items in the update table in that region, the DRAM maintaining a set of linked lists, each identifying all regions with the same number of updates in the update table.

Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

Abstract: Systems and methods for rescheduling passengers are provided. One example aspect of the present disclosure is directed to a method for rescheduling passengers. The method includes receiving an indication that an event has disrupted a plurality of flights. The method includes identifying a plurality of itineraries. The method includes determining a plurality of sets for the itineraries. The method includes determining a plurality of operations plan alternatives based on the plurality of sets. The method includes determining one or more constraints from the plurality of sets of itineraries. The method includes applying the one or more constraints to the plurality of operations plan alternatives to determine an impact of the one or more constraints to the plurality of operations plan alternatives on the sets of itineraries. The method includes determining an operations plan comprising a schedule for the plurality of flights.

Abstract: A person support apparatus, such as a bed, cot, stretcher, chair, or the like, includes a frame, a support surface supported by the frame, a plurality of load cells that detect weight supported on the support surface, at least one A/D converter, and a controller. The load cells output analog signals that are converted to digital by the A/D converters. The controller switches a sampling rate of the A/D converters between at least first and second rates. The outputs from the load cells are forwarded to a plurality of signal acquisition nodes that include the A/D converters. The nodes are positioned at locations that minimize the length of travel of the analog signals, thereby reducing noise interference. Shivering, occupant absence/presence, vital signs, occupant movement, and/or other parameters are detected by the load cells.

Abstract: A patient support apparatus includes a frame, a patient support surface, one or more force sensors that detect weight on the patient support surface, a recharger, and a controller. The recharger is adapted to recharge a personal electronic device of the patient's. The controller controls power supplied to the recharger based on outputs from the force sensors. Additionally or alternatively, a barrier is provided having a coil therein. The recharger includes a magnet for magnetically coupling to the barrier, and the recharger wirelessly receives power from the coil when the recharger is magnetically coupled to the barrier. Alternatively, the magnet holds a personal electronic device that receives power wirelessly from a coil inside the barrier. In still another variation, a pendant is included for controlling movement of the patient support apparatus and the pendant includes a recharger adapted to recharge a personal electronic device.

Abstract: Patient support apparatuses, such as beds, cots, stretchers, recliners, operating tables, and the like include wireless mesh network transceivers that enable them to communicate with each other, and other devices, via mesh networks and/or ad hoc networks. One or more additional wireless transceivers are included, such as WiFi transceivers that enable direct communication with a healthcare facility network, such as an Ethernet. The mesh network communication between patient support apparatuses and other devices is used for any one or more of: extending the communication range of the existing IT infrastructure, efficiently routing data to the healthcare facility network, determining location of the patient support apparatuses and devices, transporting patient data from one patient support to the next as the patient moves, and for other aspects.

Abstract: The present invention is concerned with compositions and methods for improving the rate of correct sample identification in indexed nucleic acid library preparations for multiplex next generation sequencing by blocking the 3? ends of pooled indexed polynucleotides from multiple samples prior to amplification and sequencing.

Abstract: A foldable shoe includes a first sole section located under the ball of a wearer's foot including a first outsole portion and a first footbed. The foldable shoe further includes a second sole section located under the heel of a wearer's foot, the second sole section including a second outsole portion and a second footbed. An upper section extends from the first sole section, and a hinge is connected to the first sole section and the second sole section and is configured to fold the foldable shoe from a first position, to be worn, to a second position, for storage. A first magnetic material disposed in the first sole section and a second magnetic material disposed in the second sole section creates a magnetic connection to retain the foldable shoe in first position or second position.

Abstract: In an example of the method, a functionalized coating layer is applied in depressions of a patterned flow cell substrate. The depressions are separated by interstitial regions. A primer is grafted to the functionalized coating layer to form a grafted functionalized coating layer in the depressions. A hydrogel is applied on at least the grafted functionalized coating layer.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: A location detection system identifies the locations of medical devices such as patient support apparatuses and/or patient care devices within a medical facility. The devices communicate via a wired connection to one or more medical facility systems (e.g. nurse call system, computer network, etc.), and/or via a wireless connection to such systems. The location detection system automatically determines location information of the devices and communicates the location information so that the recipient of any outgoing alerts and/or other information sent from the devices is apprised of the location of the particular device sending the alert or other information. Caregivers are thereby able to respond to the correct location of an alert, and software systems such as EMR systems, admission discharge and transfer (ADT) systems, etc. are able to correlate transmitted device data with the location and/or patient assigned to that location.

Abstract: An airline operations system, controller and method reschedules flights affected by a disruption that precludes a planned schedule for the flights. The method includes obtaining data related to a scheduled origination and a scheduled destination for each of a set of passengers scheduled on the flights, generating a passenger connection network of connections between the scheduled origination and the scheduled destination for a subset of the set of passengers, applying at least one criterion to the passenger connection network and rescheduling at least one connecting flight based on the criteria. The system and controller solves a network flow problem to reschedule a subset of connecting flights to have a delayed projected departure time. Resulting output can include the set of delayed flights along with modified projected departure times, a set of flight cancellations and a set of passengers with missed connections.