Abstract: At least some embodiments of the present disclosure are directed to an electroporation ablation system for treating targeted tissue in a patient. The electroporation ablation system comprises an ablation catheter including catheter electrodes configured to generate electric fields in the targeted tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections; a controller configured to receive a first pulse voltage of a first electrical pulse sequence measured during a first therapy section of the plurality of therapy sections; and determine a charge voltage based on the first pulse voltage; and an electroporation generator. The electroporation generator is operatively coupled to the catheter electrodes and the controller and configured to deliver a second electrical pulse sequence at a controlled pulse voltage for a second therapy section of the plurality of therapy sections.

Abstract: Corn plants exhibiting broad-spectrum resistance to Exserohilum turcicum are provided, together with methods of producing, identifying, or selecting plants or germplasm with a Exserohilum turcicum resistance phenotype. Such plants include sweet corn plants as well as agronomically elite dent corn plants comprising introgressed genomic regions conferring disease resistance. Compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are further provided.

Abstract: A hydraulic fracturing system can include valve apparatuses that control the delivery of fluid to high-pressure pumps that supply the fluid to a wellhead. The valve apparatuses can receive electronic signals from a control system to regulate the flow rate of the fluid to the high-pressure pumps. In one or more examples, the flow rate of the fluid can be controlled such that proppant in the fluid remains in solution.

Abstract: Techniques for determining a direction of arrival of an emergency are discussed. A plurality of audio sensors of a vehicle can receive audio data associated with the vehicle. An audio sensor pair can be selected from the plurality of audio sensors to generate audio data representing sound in an environment of the vehicle. An angular spectrum associated with the audio sensor pair can be determined based on the audio data. A feature associated with the audio data can be determined based on the angular spectrum and/or the audio data itself. A direction of arrival (DoA) value associated with the sound may be determined based on the feature using a machine learned model. An emergency sound (e.g., a siren) can be detected in the audio data and a direction associated with the emergency relative to the vehicle can be determined based on the feature and the DoA value.

Abstract: Geospatial data can be converted into audio outputs. For example, a system can receive a dataset indicating geospatial locations of objects within a region. Based on the dataset, the system can generate a virtual map representing the region and including virtual points representing the objects. The virtual points can be spatially positioned at locations in the virtual map corresponding to the geospatial locations of the objects in the region. The system can receive a user input via a user input device for interacting with a particular virtual point among the virtual points in the virtual map. The system can determine one or more sound characteristics for a sound based on receiving the user input. The system can then transmit an audio signal to an audio device for causing the audio device to generate the sound having the one or more sound characteristics, which may assist with exploring the virtual map.

Abstract: A locator device includes a housing, a plurality of directional indicators, a first button, a second button, a memory, and a GPS device. The device also includes a processor adapted to determine that the first button has been pressed, and, in response, obtain from the GPS device first location data representing a first location of the device, and store the first location data in the memory. The processor is further adapted to determine that the second button has been pressed, and in response, retrieve the first location data from the memory, obtain from the GPS device second location data representing a second location of the device, determine a direction from the second location to the first location, identify a directional indicator corresponding to the direction, and illuminate the identified directional indicator to indicate the direction.

Abstract: Methods and devices for issuing ablation therapy using a cardiac signal as a trigger for therapy delivery. The cardiac signal itself may be analyzed before and/or between pulsed electrical field outputs to determine when, relative to fiducials within the cardiac signal, the output can safely be delivered. In some examples, the timing of therapy delivery is tailored to the patient's current cardiac state, such as the cardiac rate. In other examples, triggering signals can be analyzed to ensure that the trigger itself is appropriately detected.

Abstract: Ablation probes and methods of their use. Example probes include probe circuits configured to provide identifying information for the probe itself. The probe circuits may sense probe usage and/or age to determine probe end of life (EOL). In response to EOL, the probe circuit generates an output indicating EOL. The probe electronic circuit may also be configured to monitor probe usage via impedance or other features, independent of such operation by an ablation pulse generator.

Abstract: Geospatial data can be converted into audio outputs. For example, a system can receive a dataset indicating geospatial locations of objects within a region. Based on the dataset, the system can generate a virtual map representing the region and including virtual points representing the objects. The virtual points can be spatially positioned at locations in the virtual map corresponding to the geospatial locations of the objects in the region. The system can receive a user input via a user input device for interacting with a particular virtual point among the virtual points in the virtual map. The system can determine one or more sound characteristics for a sound based on receiving the user input. The system can then transmit an audio signal to an audio device for causing the audio device to generate the sound having the one or more sound characteristics, which may assist with exploring the virtual map.

Abstract: Systems and methods for performing and controlling ablation therapy. Examples provide adaptive therapy outputs that allow a user to select among various feedback parameters, parameter limits, and therapy profiles, to be implemented by an ablation system. The ablation system adaptively issues therapy by monitoring one or more feedback parameters to determine changes to make to therapy outputs.

Abstract: Techniques for determining a direction of arrival of an emergency are discussed. A plurality of audio sensors of a vehicle can receive audio data associated with the vehicle. An audio sensor pair can be selected from the plurality of audio sensors to generate audio data representing sound in an environment of the vehicle. An angular spectrum associated with the audio sensor pair can be determined based on the audio data. A feature associated with the audio data can be determined based on the angular spectrum and/or the audio data itself. A direction of arrival (DoA) value associated with the sound may be determined based on the feature using a machine learned model. An emergency sound (e.g., a siren) can be detected in the audio data and a direction associated with the emergency relative to the vehicle can be determined based on the feature and the DoA value.

Abstract: A device includes a memory location adapted to store data, a GPS device adapted to generate information representing a location of the device, a motion detector adapted to determine when the device experiences a predetermined movement, and one or more directional indicators adapted to display a selected direction. The device also includes a processor that performs the following steps: obtain from the GPS device first location data representing a first location, and store the first location data in the memory location. Subsequently, in response to a determination that the device has experienced the predetermined movement, the processor retrieves the first location data from the memory location, obtains from the GPS device second location data representing a second location, determines a direction from the second location to the first location, and causes the one or more directional indicators to indicate the direction.

Abstract: Electrosurgical generators having improved functionality and user interface. In an example, the user may modify therapy output parameters without interrupting therapy delivery within a therapy regimen. In an example, the display shows both therapy amplitudes and encountered impedances for a plurality of therapy pulses in different portions of a display. In an example, the electrosurgical generator is operable in a triggered mode using a cardiac signal trigger and provides the operator with an estimate of remaining time that is calculated in light of a calculated cardiac rate.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: The present disclosure provides maize plants exhibiting broad spectrum resistance to Northern Leaf Blight (NLB). Maize plants with multiple NLB resistance loci located in cis linkage on chromosome 8 are provided. Compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are further provided.

Abstract: The inventive alignment frame simplifies the task of attaching a fixation frame to a patient's skull prior to radiotherapy treatments. The frame is adjustably attachable to the fixation frame and is equipped with a bite plate that allows a patient to bite down on the bite plate to immobile the alignment-calibration frame and the attached fixation frame. The positional relationships are adjusted to bring the fixation screws into optimal locations on the patient's skull. Needle calibration assemblies placed into the fixation screw holders include clear needle guides through which a hypodermic needle is inserted to inject anesthetic into the future fixation screw location. The needle calibration assemblies are removed and the optimal length fixation screw is tightened into the anesthetized location. After all the fixation screws are in place, the patient releases the bite plate and the entire alignment-calibration frame is removed from the fixation frame.

Abstract: The present disclosure provides maize plants exhibiting broad spectrum resistance to Northern Leaf Blight (NLB). Maize plants with multiple NLB resistance loci located in cis linkage on chromosome 8 are provided. Compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are further provided.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: Methods and devices for performing ablation using spatially multiplexed waveforms are disclosed. The increased efficacy of monophasic waveforms is combined with the reduced side effects of biphasic waveforms by distributing components of the waveform across multiple electrodes. Charge balancing occurs upon completion of therapy delivery within a time period that avoids muscle stimulation, while allowing unbalanced waveforms to be delivered during stimulation.

Abstract: Methods and devices for performing ablation using time multiplexed waveforms are disclosed. The increased efficacy of monophasic waveforms is combined with the reduced side effects of biphasic waveforms by distributing components of the waveform across over a broader time interval than that typically used in a conventional biphasic waveform. Charge balancing occurs upon completion of therapy delivery within a time period that avoids muscle stimulation, while allowing unbalanced waveforms to be delivered during stimulation.