Patents by Inventor Jonathan Alan Medlock

Jonathan Alan Medlock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10370314
    Abstract: The present invention relates to a selective reduction of esters to their corresponding alcohols.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: August 6, 2019
    Assignee: DMS IP ASSETS B.V.
    Inventors: Matthias Beller, Werner Bonrath, Johannes Gerardus De Vries, Yuting Fan, Sandra Hinze, Laurent Lefort, Jonathan Alan Medlock, Pim Puylaert, Richard Van Heck
  • Publication number: 20190144365
    Abstract: The present invention relates to a selective reduction of esters to their corresponding alcohols.
    Type: Application
    Filed: May 11, 2017
    Publication date: May 16, 2019
    Inventors: Matthias BELLER, Werner BONRATH, Johannes Gerardus DE VRIES, Yuting FAN, Sandra HÜBNER, Laurent LEFORT, Jonathan Alan MEDLOCK, Pim PUYLAERT, Richard VAN HECK
  • Patent number: 10252962
    Abstract: The present invention relates to a new process for the production of D-sorbitol.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: April 9, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Mae Joanne Aguila, Hans Peter Hohmann, Laurent Lefort, Jonathan Alan Medlock, Guenter Pappenberger
  • Publication number: 20190039980
    Abstract: The present invention relates to an improved way for the production of farnesol.
    Type: Application
    Filed: September 16, 2016
    Publication date: February 7, 2019
    Inventors: Werner BONRATH, Raphael BEUMER, Jonathan Alan MEDLOCK
  • Publication number: 20180370887
    Abstract: The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.
    Type: Application
    Filed: November 28, 2016
    Publication date: December 27, 2018
    Applicant: DSM IP Assets B.V.
    Inventors: Ulla LETINOIS, Stephan ACKERMANN, Jonathan Alan MEDLOCK, Hajo LEHMANN
  • Publication number: 20180290133
    Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
    Type: Application
    Filed: March 27, 2018
    Publication date: October 11, 2018
    Inventors: Alan DYKE, Damian Mark GRAINGER, Jonathan Alan MEDLOCK, Hans Guenter NEDDEN, Jacques Jean Marie LE PAIH, Stephen James ROSEBLADE, Andreas SEGER, Vilvanathan SIVAKUMAR, Antonio ZANOTTI-GEROSA
  • Patent number: 10059738
    Abstract: The present invention is related to a novel and improved process for the manufacture of compounds of formula (I) or salts thereof herein designated as benzylsulfonyl-Ser-X-4-amidinobenzylamide, wherein R is a C1 to C6 linear or branched aliphatic hydrocarbon chain optionally substituted with a C6 to C10 aromatic group.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: August 28, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jonathan Alan Medlock, Peter Wikstroem
  • Patent number: 10047019
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and a halogenated alcohol. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: August 14, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jonathan Alan Medlock, Gerardus Karel Maria Verzijl, Edwin Gerard Ijpeij, Andreas Hendrikus Maria De Vries
  • Publication number: 20180201959
    Abstract: The present invention relates to a novel and inventive process for the production of sorbitol from D-sucrose.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 19, 2018
    Inventors: Mae Joanne AGUILA, Hans-Peter HOHMANN, Laurent LEFORT, Jonathan Alan MEDLOCK, Guenter PAPPENBERGER
  • Publication number: 20180201558
    Abstract: The present invention relates to a new process for the production of D-sorbitol.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 19, 2018
    Inventors: Mae Joanne AGUILA, Hans Peter HOHMANN, Laurent LEFORT, Jonathan Alan MEDLOCK, Guenter PAPPENBERGER
  • Patent number: 9981935
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: May 29, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jonathan Alan Medlock, Ulla Letinois, Thomas Netscher, Werner Bonrath
  • Publication number: 20170145054
    Abstract: The present invention is related to a novel and improved process for the manufacture of compounds of formula (I) or salts thereof herein designated as benzylsulfonyl-Ser-X-4-amidinobenzylamide, wherein R is a C1 to C6 linear or branched aliphatic hydrocarbon chain optionally substituted with a C6 to C10 aromatic group.
    Type: Application
    Filed: June 1, 2015
    Publication date: May 25, 2017
    Inventors: Jonathan Alan MEDLOCK, Peter WIKSTROEM
  • Patent number: 9611200
    Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: April 4, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Johannes Tschumi, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Patent number: 9573872
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: February 21, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Patent number: 9561989
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: February 7, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Patent number: 9458076
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: October 4, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Patent number: 9452961
    Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 27, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Johannes Tschumi, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Publication number: 20160271599
    Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
    Type: Application
    Filed: May 27, 2016
    Publication date: September 22, 2016
    Inventors: Alan Dyke, Damian Mark Grainger, Jonathan Alan Medlock, Hans Guenter Nedden, Jacques Jean Marie Le Paih, Stephen James Roseblade, Andreas Seger, Vilvanathan Sivakumar, Antonio Zanotti-Gerosa
  • Patent number: 9416100
    Abstract: The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: August 16, 2016
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Alan Dyke, Damian Mark Grainger, Jonathan Alan Medlock, Hans Guenter Nedden, Jacques Jean Marie Le Paih, Stephen James Roseblade, Andreas Seger, Vilvanathan Sivakumar, Antonio Zanotti-Gerosa
  • Publication number: 20160185702
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 30, 2016
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, René Tobias STEMMLER, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES