Abstract: Methods and systems for generating a diversification index for a portfolio are disclosed herein. A plurality of assets within the portfolio are identified, each of the plurality of assets having a corresponding weight value and a corresponding utility value. An overall volatility value of the portfolio is identified. A diversification index is computed based on the overall volatility value and corresponding weight and volatility values of each of the plurality of assets.

Abstract: According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves within a wall of (e.g., within adventitia surrounding a lumen of) an artery or other blood vessel, such as the common hepatic artery.

Abstract: Methods and systems for designing, optimizing, and manufacturing electric machine components are described herein. In some embodiments, the components are designed and optimized using artificial intelligence and manufactured using additive manufacturing.

Abstract: Techniques and systems for collaborative document editing and generating feedback on draft documents are described. A draft document is shared with multiple readers in a file format that is the same or similar to the file format in which the document will be published. The readers provide comments on the draft document. The comments can be stored in the same file as the document. Feedback may be solicited from a reader based on reading activity while interacting with the document.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: A system and method for voltage-guided anatomical shell editing includes outputting, to a display device, an anatomical shell of a cardiac structure. The anatomical shell is based on signals sensed by a mapping probe, each signal including a respective sensed voltage. User input specifying a first target depth for editing is received, as is a selection of a first region of the anatomical shell. A modified anatomical shell is generated by removing a first portion of the anatomical shell including the selected first region to a first editing depth based on the first target depth and generating a new surface region on the modified anatomical shell. Based on the voltage associated with the new surface region, the edit can be maintained, undone, and/or modified.

Abstract: A method uses an electromagnetic tracking system, including a number of field transmitters and at least one receiver, to determine location information associated with a medical device. The method includes transmitting a set of electromagnetic signals, each signal having a frequency that is different than a frequency associated with each of the other signals, where each signal corresponds to a sum of sinusoidal functions, each of which includes an amplitude and a frequency. A field signal is received, and includes an undistorted field component and a distortion component. The amplitudes and frequencies of the sinusoidal functions are selected such that the distortion component includes a residual error arising from terms of at least a specified order in frequency. Field components corresponding to the field transmitters are extracted from the received signal, and the location information is determined based on the field components.

Abstract: Systems and methods for testing printed circuit boards (PCBs) are disclosed herein. In one embodiment, a tester for printed circuit boards (PCBs) includes a test fixture having a plurality of electrical contacts for contacting the PCBs that are units under test (UUTs). The test fixture carries a remote test peripheral master (RTPM) module, and a remote test peripheral slave (RTPS) module. The RTPM module and the RTPS module are connected through a remote test peripheral (RTP) bus.

Abstract: A roll control system controls roll control surfaces of an aircraft that are capable of causing the aircraft to perform a roll maneuver by respectively deflecting in upward and downward directions. The roll control system includes deflection limiter units for respectively limiting angles of deflection of the roll control surfaces, and further includes deflection rate limiter units for respectively limiting rates of deflection of the roll control surfaces. The deflection limiter unit limits the roll control surfaces to deflection distances and deflection rates based at least in part on the deflection direction of the roll control surfaces. For a given set of flight conditions, such as airspeed, if a roll control surface is deflecting upwardly, it is less limited by the roll control system in terms of deflection distance and deflection rate than if the roll control surface is deflecting downwardly.

Abstract: A skimming apparatus with a pivot arm and a drive follower on the pivot arm that guides a belting to facilitate precise placement of the belting for efficient skimming.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: The field of the invention is cellular and molecular biology and stem cells. Specifically, the disclosure is directed to a formulation for harvesting and passaging single cell human pluripotent stem cells comprising: (i) 1 mM to about 30 mM sodium citrate; (ii) a salt comprising 10 mM to 170 mM KCl or NaCl; and (iii) Ca2+/Mg2+-free Dulbecco's phosphate buffered saline (DPBS), wherein said formulation has an osmolarity of about 100 mOsmol/liter to about 350 mOsmol/liter. The formulation can be used for serial passaging and dislodging of pluripotent stem cells attached to 2D tissue culture vessels or grown in 3D suspension culture (small scale and large scale bioreactors) or any other application where passaging in the form of single cell population of stem cells is needed.

Abstract: Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels. Further, the formulations and methods provide high yields of harvested cells for subsequent passaging and high post-harvest cell viability. Pluripotent stem cells passaged with the formulations according to the methods remain undifferentiated and express typical stem cell markers, while, at the same time, they retain the differentiation capability and are able to differentiate into the cells in all three germ layers and generate teratomas, even after numerous rounds of harvesting and passaging. These hPSCs also maintain normal karyotype after passaged with the formulations for extended period of time.

Abstract: A method and system to control a rotor system includes providing a controller communicably coupled to the rotor system, and automatically changing a rotor speed of the rotor system from a first rotor speed in a first flight mode to a second rotor speed in a second flight mode over a time period using the controller in accordance with an acceleration-rate profile that varies over the time period.

Abstract: A skimming apparatus with a pivot arm and a drive follower on the pivot arm that guides a belting to facilitate precise placement of the belting for efficient skimming.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

Abstract: Instruments, methods, and kits are disclosed for performing fast thermocycling.

Abstract: A multiport container system for use in cell culture processes in the field of regenerative medicine is disclosed. Specifically, the container system can have a port that connects to a fill tubing for media and reagent addition, and additional ports for tubing and connectors which are compatible to various types of cell therapy bioreactors, single use bags, as well as different sampling and cell culture systems. The multiport container system can be used for cell production processes where a single bag could be used to fill, transport, and store media or reagents, as well as to seed and feed cells into different types of culture platform. The disclosed multiport container system can be used for the streamlining of process work flow which enable rapid process development and process transfer into cell product manufacturing.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.