Abstract: An example fabrication system includes a light source, a resin container, and a base plate on which resin is cured using the light source so as to build up an object one layer at a time. The disclosed base plate includes a build surface and an anchor channel that extends into the base plate from the build surface. The anchor channel is a recess in the base plate configured to have a narrow width that is closer to an opening to the build surface than a broad width. The base plate can also have a light source that emits light into the anchor channel to cure resin within the anchor channel. Resin anchors cured within the anchor channel to conform to the anchor channel resist being extracted, and an object formed on the build surface remains anchored during fabrication via adhesion to the resin anchors.

Abstract: The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated, e.g., by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy.

Abstract: A netting material having a length dimension and a width dimension much smaller than the length dimension comprises a flap folded from a fold region of the netting material along a longitudinal fold line at a distance from a longitudinal edge of the netting. The flap therefore comprises at least two layers of the netting material folded together. One or more eyelets are provided in the flap.

Abstract: A device for collecting a tissue sample includes an outer needle extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough. The device also includes an inner needle extending longitudinally from a proximal end to a distal end and including an opening extending laterally in and along a length thereof. The inner needle is sized and shaped to be slidably received within the lumen of the outer needle and movable relative thereto between an insertion configuration, in which the opening is covered by the outer needle, to a tissue collecting configuration, in which the opening is exposed. In addition, the device includes a handle assembly for adjusting a throw length of the inner needle relative to the outer needle.

Abstract: One or more medical devices may be provided that may be used, for example, in bariatric surgery including a vertical sleeve gastrectomy. Occlusion devices can be integrated with a catheter or tube to occlude one or more proximal or distal landmarks of a stomach and a stapling guide may be used to occlude a lateral boundary of the stomach to define a cavity. A volume of the potential resultant sleeve may be determined by inserting fluid or gas into the catheter or tube, measuring pressure, and calculating the volume of the cavity.

Abstract: Techniques for planar region-guided estimates of 3D geometry of objects depicted in a single 2D image. The techniques estimate regions of an image that are part of planar regions (i.e., flat surfaces) and use those planar region estimates to estimate the 3D geometry of the objects in the image. The planar regions and resulting 3D geometry are estimated using only a single 2D image of the objects. Training data from images of other objects is used to train a CNN with a model that is then used to make planar region estimates using a single 2D image. The planar region estimates, in one example, are based on estimates of planarity (surface plane information) and estimates of edges (depth discontinuities and edges between surface planes) that are estimated using models trained using images of other scenes.

Abstract: Software specification translation includes: receiving a first software specification specified in a first programming language, a second software specification specified in a second programming language, a third software specification specified in a third programming language different from the first and second programming languages, the third software specification defining one or more data relationships between the first software specification and the second software specification. A combined representation of the first software specification and the second software specification is formed in a fourth programming language different from the first, second, and third programming languages. Connections are formed in the fourth programming language between a representation of the first software specification and the representation of the second software specification according to identified data relationships.

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.

Abstract: An ultrasonic surgical instrument includes an inner tube, an outer tube, an ultrasonic blade, and a clamp member pivotably moveable relative to the ultrasonic blade. The ultrasonic blade is acoustically coupled to an ultrasonic transducer. The clamp member pivotably movable relative to the ultrasonic blade between an open configuration and an approximated configuration with respect to the ultrasonic blade, wherein the clamp member is pivotably coupled to the inner tube, wherein the clamp member is pivotably coupled to the outer tube, and wherein movement of the outer tube relative to the inner tube between the first position and the second position transitions the clamp member between the open configuration and the approximate configuration.

Abstract: Disclosed herein are methods, non-transitory computer-readable medium, and systems for determining an estimate of fat within a volume of a subject by determining a parameter ? from the signal intensities of at least three echo signals emitted from a region of the volume of a subject imaged by a magnetic resonance image scanner in response to an applied RF pulse, wherein the three echo signals are taken at a first opposing-phase echo time, a second opposing-phase echo time and an in-phase echo time; and determining a fat volume fraction, f, from the parameter ?.

Abstract: The invention relates to a process for extracting metals and salts from titanium-bearing minerals such as perovskite. More particularly, although not exclusively, the invention relates to extracting titanium dioxide and optionally other compounds from melter slag derived from an iron-making process.

Abstract: A system can monitor data usage, including an amount of searchable data used and/or a rate at which the searchable data is manipulated, on a storage allocation in a networked environment. The storage allocation can have a quantity/number of partitions, including at least one partition, configured to store the searchable data. The system can detect that the data usage is beyond a specified threshold and then based at least in part on factors such as network traffic, CPU usage, and/or data usage, the system can modify the storage allocation to increase or decrease a size of the partition and/or the quantity of partitions. Network traffic for the storage allocation can be directed away from the portion of the storage allocation being modified. When modifying the storage allocation is complete, the network traffic can be directed to the modified portion of the storage allocation.

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.

Abstract: A vehicle includes a battery control module and a controller. The battery control module is configured to issue at regular intervals a message indicative of a state of charge (SOC) of a battery. The controller is configured to, in an absence of receiving the messages at the regular intervals while in a key-on state and a torque demand is present, restrict power flow between the battery and an electric powertrain to a limit that is based on a predicted SOC to provide limited propulsive force.

Abstract: A thrust control assembly for use in a horizontal pumping system includes a thrust bearing chamber that is filled with a fluid lubricant, a thrust bearing assembly contained within the thrust bearing chamber, a first radial bearing chamber, a first radial bearing assembly contained within the first radial bearing chamber and a first metering assembly. The first metering assembly controls the flow of lubricant from the thrust bearing chamber to the first radial bearing chamber. The first metering assembly may include an orifice plate.

Abstract: A base device has a first waveguide positioned on a first base. The waveguide is at least partially defined by a ridge extending away from the first base. An auxiliary optical device has a second waveguide positioned on a second base. The second optical device is immobilized on the base device such that the second waveguide is between the first base of the first optical device and the second base of the auxiliary device. The first waveguide is optically aligned with the second waveguide such that the first waveguide and second waveguides can exchange optical signals.

Abstract: A privacy management system that is adapted for, in the course of processing a particular data subject access request, automatically determining a type of the data subject access request, such as: (1) a request to delete personal data of the requestor that is being stored by a particular organization; (2) a request to provide, to the requestor, personal data of the requestor that is being stored by the particular organization; (3) a request to update personal data of the requestor that is being stored by the particular organization; and (4) a request to opt out of having the particular organization use the requestor's personal information in one or more particular ways. After making this determination, the system may determine, based on the determined type of data subject access request, a particular workflow to follow in processing the data subject access request, and then execute the determined workflow.

Abstract: A method of performing structural analysis relating to a component having CAD-based geometry, refined CAD-based geometry and CAD-based FEA data associated therewith. The method includes scanning the component to obtain scan-based point cloud geometry of the component, aligning the scan-based point cloud geometry with the CAD-based geometry of the component, generating scan-based geometry of the component by refining the scan-based point cloud geometry, comparing the scan-based geometry with the refined CAD-based geometry of the component to quantify geometric differences therebetween, generating scan-based FEA geometry of the component by meshing the scan-based geometry, performing finite element analysis on the scan-based FEA geometry to obtain scan-based FEA data and comparing the scan-based FEA data with the CAD-based FEA data of the component to quantify the effect of geometric difference therebetween.

Abstract: A method for processing a semiconductor wafer uses non-contact electrical measurements indicative of at least one tip-to-tip short or leakage, at least one via-chamfer short or leakage, and at least one corner short or leakage, where such measurements are obtained from cells with respective tip-to-tip short, via-chamfer short, and corner short test areas, using a charged particle-beam inspector with a moving stage and beam deflection to account for motion of the stage.

Abstract: Polythioether polymers, sealants containing polythioether polymers, and compounds useful as stabilizing monomers in the manufacture of polythioether polymers are provided. In many embodiments the polymers and sealants demonstrate reduced risk of spoilage that may be caused by low temperature storage of the polymer or uncured sealant. Compounds useful as stabilizing monomers include compounds according to formula I: CH2?CR1—CHR2—S—R3—S—CHR4—CR5?CH2 [I] wherein R1, R2, R4 and R5 are independently selected from —H, —CH3 or —C2H5, and wherein R3 is selected from divalent groups comprising 2-12 carbon atoms, 0-5 ether oxygen atoms and 0-5 thioether sulfur atoms, which may be straight, branched or cyclic.