Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Abstract: Systems and methods are disclosed to optimize resources of a medical device system, including to analyze physiologic information of a patient occurring over specific time periods relative to a prior heart failure event, to adjust, in response to a detected or received trigger event, a baseline value for the patient from a long-term baseline value to one of a shorter-term baseline value or a static value indicative of a baseline value at a prior time relative to the detected or received trigger event, to determine a readmission score for the patient based on the analyzed physiologic information, and to provide a control signal to control a mode or operation of the medical device system based on the readmission score to optimize resources of the medical device system.

Abstract: A medical device includes a processor, an acceleration sensor, and memory. The acceleration sensor is configured to generate acceleration data that comprises a plurality of acceleration measurements. The memory comprises instructions that when executed by the processor, cause the processor to: obtain the acceleration data from the acceleration sensor; and determine, based on the acceleration data, that the medical device has flipped.

Abstract: Techniques for routing communication to a common audio output device connected multiple audio signal source devices are disclosed. For each of audio signal source devices, a set of inputs are assessed. The set of inputs can include: an operational state of the audio signal source device, an interaction with the audio signal source device, an audio-producing application being executed by the audio signal source device, or a degree of user interaction with the audio-producing application. At a point in time, an audio routing score is generated for each of the audio signal source devices according to a weighted calculation of the set of inputs based on the assessing. Finally, an audio signal routing decision is made, to route an audio signal from one of the audio signal source devices to the audio output device, based on the audio routing score for each of the audio signal source devices.

Abstract: In some implementations, a user device can predictively route media content to a remote playback device based on playback context information obtained by the user device. The playback context can include local playback context information related to the state and/or context of the user device. The playback context can include remote playback context information related to the state and/or context of available remote playback devices. Based on the playback context information obtained by the user device, the user device can generate a predictive score for each available playback device that indicates or predicts the likelihood that the user will want to send media content to the corresponding playback device. The user device can generate and present a graphical user interface that can identify the playback devices having predictive scores over a threshold score. In some instances, the user device can automatically route selected media content to a predicted playback device.

Abstract: An ambulatory medical device includes a multi-axis posture sensor and processing circuitry. The multi-axis posture sensor is configured to provide an electrical posture sensor output representative of alignment of respective first, second, and third non-parallel axes of the ambulatory medical device with the gravitational field of the earth. The processing circuitry is configured to determine that the subject avoids lying on their left side using the posture sensor output, and compute a metric predictive of one or both of orthopnea and trepopnea in response to determining that the subject avoids lying on their left side.

Abstract: Systems and methods for monitoring and managing aortic stenosis are disclosed. An exemplary medical-device system comprises a data receiver to receive heart sound information sensed by ambulatory heart sound sensors, and a stenosis detector to detect a change in aortic valve surface area from a baseline stenosis-free state using heart sound components such as S1 and S2 sounds. Based on the change in aortic valve surface area, the stenosis detector can generate an aortic stenosis indicator indicating a presence and severity of aortic stenosis. Such indicator can be provided to a user, trigger symptom monitoring and evaluation of functional deterioration in the patient, facilitate assessment of patient candidacy for aortic valve replacement, or triage heart failure management strategies.

Abstract: Systems and techniques are provided for enhancing media content. In some examples, a network device of a network can detect a first event tag in an item of media content. The first event tag is associated with a first event in the item of media content and a first functionality of a first client device connected to the network. The first functionality corresponds to the first event in the item of media content. The network device can transmit, based on detecting the first event tag in the item of media content, a first activation message to the first client device to cause the first client device to perform the first functionality corresponding to the first event in the item of media content.

Abstract: In some implementations, a user device can predictively route media content to a remote playback device based on playback context information obtained by the user device. The playback context can include local playback context information related to the state and/or context of the user device. The playback context can include remote playback context information related to the state and/or context of available remote playback devices. Based on the playback context information obtained by the user device, the user device can generate a predictive score for each available playback device that indicates or predicts the likelihood that the user will want to send media content to the corresponding playback device. The user device can generate and present a graphical user interface that can identify the playback devices having predictive scores over a threshold score. In some instances, the user device can automatically route selected media content to a predicted playback device.

Abstract: Embodiments herein relate to body vibration analysis systems and methods. In an embodiment, a body vibration analysis system is included having a first light source configured to illuminate a surface of the body from a first angle with a first set of lighted features and a second light source configured to illuminate a surface of the body from a second angle with a second set of lighted features, wherein the second set of lighted features are optically distinguishable from the first set of lighted features. The system further includes a camera configured to detect light reflected from the surface of the body and a control circuit configured to receive an input from the camera and assess spatial vibration as a function of location on the surface of the body. Other embodiments are also included herein.

Abstract: Embodiments herein relate to systems for tracking and maintaining the integrity of patient device data over extended periods of time. In a first aspect, a medical device system is included having an implantable device that can include a control circuit, a communication circuit, and one or more sensors. The system can also include an external device including a control circuit and a communication circuit. The external device can be configured to receive patient data from the implantable device and execute a hashing operation on units of received patient device data and one or more previous digest packets to create new digest packets. The external device can be configured to store the new digest packets and forward digest packets onto another device of the medical device system when requested to allow patient data to be authenticated. Other embodiments are also included herein.

Abstract: Controlling the output of audio based on the mode of an electronic device having a sound mode, silent mode, and mute mode, along different audio output routes. In the sound mode, all audio can be output, while only registered or authorized audio can be output in the silent mode. In the mute mode, no audio can be output. The sound and silent modes can be enabled using an interface of the device, while the mute mode can be enabled using an accessory coupled to the device. To disengage the mute mode, a user can provide a corresponding instruction using the accessory or providing an instruction on the device related to volume control. Other aspects are also described and claimed.

Abstract: Systems and methods for monitoring heart failure status in a patient are discussed. A medical-device system receives physiological and clinical information of the patient, and classifies the patient into one of a plurality of phenotypes using the received information. The plurality of phenotypes each can be characterized by a cluster physiological, clinical, demographic, or comorbidity features in a multi-dimensional feature space. Based on the classified phenotype, a heart failure detector determines a heart failure detection setting for the patient, and detects a heart failure status in the patient using the heart failure detection setting. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected heart failure status.

Abstract: Systems and methods for detecting and managing heart failure are discussed. A medical-device system receives heart sound information sensed from the patient, generates a heart sound metric using the received heart sound information, and generate a heart failure indicator indicating whether the patient has a heart failure with preserved ejection fraction (HFpEF) or a heart failure with reduced ejection fraction (HFrEF) based at least in part on the heart sound metric. The medical-device system can detect a transition from HFpEF to HFrEF. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected transition from HFpEF to HFrEF.

Abstract: Systems and methods for monitoring heart failure status in a patient are discussed. A medical-device system includes a storage device to store a correspondence between one or more heart failure comorbidities and corresponding one or more heart failure detection settings, and a heart failure detector circuit to detect a heart failure status of the patient. The heart failure detector circuit receives physiological information and heart failure comorbidity information of the patient, determines a detection setting for the patient based on the received comorbidity information and the stored correspondence, and detect a heart failure status using the received physiological information and the identified detection setting. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected heart failure status.

Abstract: In some implementations, a system can be configured to allow remote control devices to quietly obtain status information related to various audio/video playback devices. For example, a streaming device (e.g., a user device, phone, etc.) can establish a streaming connection to a playback device. The playback device can be configured to only accept a single streaming connection (i.e., master connection). A remote control device (e.g., a user device, phone, etc.) can quietly connect (i.e., control connection) to the playback device without interrupting the master connection to obtain status information related to the playback device and or the media being streamed to the playback device. The remote control device can provide commands through the control connection to adjust the playback of the streamed media at the playback device.

Abstract: Systems and techniques are described herein for annotating media content. For example, a process can include obtaining media content and generate, use one or more machine learning models, a metadata file for at least a portion of the media content. The metadata file includes one or more metadata descriptions. The process can include generating a text description of the media content based on the one or more metadata descriptions of the metadata file. The process can include annotating the media content use the text description.

Abstract: A system and method for routing communication to a common audio output device connected to each of two or more audio signal source devices. For each of the two or more audio signal source devices, a set of inputs are assessed. The set of inputs include: an operational state of the audio signal source device, an activity the audio signal source device, an audio-producing application being executed by the audio signal source device, and a degree of user activity with the audio-producing application being executed by the audio signal source. At a point in time, an audio routing score is generated for each of the two or more audio signal source devices according to a weighted calculation of the set of inputs based on the assessing. Finally, an audio signal routing decision is made, to route an audio signal from one of the two or more audio signal source devices to the audio output device, based on the audio routing score for each of the two or more audio signal source devices.

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Formula (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Abstract: Systems and methods for detecting a blockage in a patient's cardiac conduction system using heart sound information is disclosed. An exemplary medical-device system includes a data receiver circuit to receive heart sound information sensed from a patient, and a controller circuit to generate a heart sound metric or characteristic from the received heart sound information. The heart sound metric can include one indicative of a presence or absence of split S1 sound. The controller circuit can detect a bundle branch block (BBB), including to discriminate a left bundle branch block (LBBB) from a right bundle branch block (RBBB), based at least in part on the heart sound metric. The BBB indicator can be provided to a user or a process executable by the medical-device system to optimize cardiac pacing and restore cardiac synchrony.