Abstract: Systems and methods for recognizing and classifying breathing patterns based on spatial analysis of chest wall or abdominal movement or acceleration are described. A medical-device system comprises a receiver circuit to receive respiration information of a patient, and a breath analyzer circuit to determine from the respiration information two or more spatial respiration components, such as accelerations of chest wall or abdominal movement in respective directions along the anatomical axes. The breath analyzer circuit can classify a breathing pattern as one of either chest breathing or diaphragmatic breathing based on the determined spatial respiration components. The classified breathing pattern can be used for detecting a physiological event such as worsening heart failure or for assessing the patient's risk of having metabolic disorders.

Abstract: Systems and methods for recognizing and tracking heart sound components are disclosed. An exemplary medical-device system comprises a data receiver circuit to receive heart sound information, and a heart sound recognition circuit to generate a representative heart sound segment within a cardiac cycle, such as an ensemble average of a plurality of heart sound segments taken from multiple cardiac cycles. The heart sound recognition circuit can partition the representative heart sound segment into multiple heart sound data windows, calculate spectral entropy values respectively for each of the multiple heart sound data windows, and determine one or more heart sound components including an S2 component using the calculated spectral entropy values. A physiologic event detector can detect a cardiac event using the recognized one or more heart sound components.

Abstract: Systems and methods are disclosed to determine a syncope metric for a patient as a function of cardiac acceleration information and the blood pressure information received from a signal receiver circuit and to determine an indication of a worsening risk of syncope or a syncope event for a patient using the determined syncope metric, wherein the determined indication of worsening risk of syncope or the syncope event can be provided to a user or a process.

Abstract: Systems and methods are disclosed to determine a P wave window for a patient using cardiac acceleration information of the patient, including a determined time of an S4 heart sound. Correlations between an S4 template and cardiac acceleration information in an S4 window having a duration longer than the S4 template can be determined. An S4 centroid can be determined as a peak of the determined multiple correlations, and the P wave window can be determined using the determined S4 centroid and an electromechanics delay.

Abstract: A computer implemented method comprising accessing representations for a plurality of corresponding media content items, each media content item having at least one corresponding representation, the representations being organized in an order in one or more sets of the representations, each representation comprising at least one of metadata for a corresponding media content item and an image for a corresponding media content item, each representation being for display to a user to enable the user to select to access the corresponding media content item, each set of representations being displayable as a scrollable list; using the order of the representations to determine display locations of the representations in the scrollable list in a display arrangement; comparing similarity of content of representations within a display range; and where representations are determined to have greater than a predetermined similarity, changing the order of at least one of the representations determined to have greater than

Abstract: Systems and methods are disclosed to determine an indication of one of an atrial fibrillation S4 heart sound or a non-atrial fibrillation S4 heart sound for an S4 signal portion of cardiac acceleration information of a patient based on determined first and second correlations of a morphology of the S4 signal portion to atrial-fibrillation and non-atrial fibrillation S4 templates, respectively, and to determine an atrial fibrillation event of the patient using cardiac electrical information of the patient and the determined indication for the S4 signal portion.

Abstract: Systems and techniques are described herein for annotating media content. For example, a process can include obtaining media content and generate, use one or more machine learning models, a metadata file for at least a portion of the media content. The metadata file includes one or more metadata descriptions. The process can include generating a text description of the media content based on the one or more metadata descriptions of the metadata file. The process can include annotating the media content use the text description.

Abstract: Systems, devices, and methods for monitoring and assessing blood glucose level in a patient are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. The physiologic information is correlated to, and different from, a direct glucose level measurement. The system determines a glucose index indicative of an abnormal blood glucose level using the received physiologic information by the two or more physiologic sensors. The system may use the glucose index to initiate or adjust a therapy, or to trigger a glucose sensor, separate from the two or more physiologic sensors, to directly measure blood glucose concentration.

Abstract: Systems and techniques are described herein for processing media content. For example, a process can include obtaining a first media frame and a second media frame. The process can include generating, using a first change detector, a first tag indicating a change above a first change threshold has occurred in the second media frame relative to the first media frame. The process can further include generating, using a machine learning model, a second tag indicating that media content of the second media frame is associated with a particular type of media content. The process can further include determining, based the first tag and the second tag, that the media content of the second media frame is associated with the particular type of media content.

Abstract: A medical device includes a processor, an acceleration sensor, and memory. The acceleration sensor is configured to generate acceleration data that comprises a plurality of acceleration measurements. The memory comprises instructions that when executed by the processor, cause the processor to: obtain the acceleration data from the acceleration sensor; and determine, based on the acceleration data, that the medical device has flipped.

Abstract: Controlling the output of audio based on the mode of an electronic device having a sound mode, silent mode, and mute mode, along different audio output routes. In the sound mode, all audio can be output, while only registered or authorized audio can be output in the silent mode. In the mute mode, no audio can be output. The sound and silent modes can be enabled using an interface of the device, while the mute mode can be enabled using an accessory coupled to the device. To disengage the mute mode, a user can provide a corresponding instruction using the accessory or providing an instruction on the device related to volume control. Other aspects are also described and claimed.

Abstract: Systems and methods for calibrating an orientation of an implantable device in a patient is described. An exemplary system includes a calibration circuit that can receive acceleration information sensed from an implantable medical device (IMD) implanted in a patient, and receive reference acceleration information sensed from a reference device associated with the patient. The acceleration information and the reference acceleration information are acquired when the patient assumes a first posture or in a first position. The calibration circuit determines a spatial relationship between an orientation of the IMD and a reference orientation of the reference device using the received acceleration information and the received reference acceleration information, and calibrate subsequent acceleration information sensed from the IMD using the determined spatial relationship to correct for the orientation of the IMD.

Abstract: Systems and methods for detecting heart sound information from a subject's head are described. A system embodiment includes a headgear to be worn on the subject's head, and first and second sensors to sense respectively first and second physiologic signals each representing vibration, motion, or displacement conducted through patient body tissue. The sensed physiologic signals contain heart sound information. At least one of the first or the second sensor is included in the headgear, and placed at a head location to sense a physiologic signal indicative of heart sounds. The system includes a processor to generate a composite signal using the sensed first and second physiologic signals. The system may generate a heart sound metric using the composite signal, and detect a cardiac event such as an arrhythmia or worsening heart failure.

Abstract: A system and method for communication between an IMD and an external reader includes bringing a portion of a patient's body into contact with a device-body contact surface of an external reader. The reader transmits a first transdermal carrier wave from the contact surface into the patient's body, where the first carrier wave includes a request for communication with the IMD. The transdermal carrier waves are electrical conductive waves, optical waves, or acoustic waves. Upon detection of the first carrier wave, the IMD transmits a second transdermal carrier wave including a request for an access key from the reader and the reader replies by transmitting a third transdermal carrier wave including the access key back to the IMD. If the access key is valid, the IMD transmits information by radio frequency (RF) in an RF communication mode or a fourth transdermal carrier wave including data from the IMD.

Abstract: This is directed to controlling the output of audio based on the mode of an electronic device. In particular, this is directed to an electronic device having a sound mode, silent mode, and mute mode controlling the output of audio along different audio output routes. In the sound mode, all audio can be output, while only registered or authorized audio can be output in the silent mode. In the mute mode, no audio can be output. The sound and silent modes can be enabled using an interface of the device (e.g., a switch having two possible states), while the mute mode can be enabled using an accessory coupled to the device. To disengage the mute mode, a user can provide a corresponding instruction using the accessory, or providing an instruction on the device related to volume control. For example, a user can change the device volume using an on-device interface, or toggle a sound/silent switch to a sound mode.

Abstract: Systems and methods are disclosed to detect a potential syncope event using cardiac acceleration information of a patient and to transition a medical device from a first low-power mode to a second high-power mode in response to the detected potential syncope event.

Abstract: Embodiments of the present disclosure relate to detecting implantable medical device orientation changes. In an exemplary embodiment, a medical device having a processor, comprises an acceleration sensor and memory. The acceleration sensor is configured to generate acceleration data that comprises a plurality of acceleration measurements. The memory comprises instructions that when executed by the processor, cause the processor to: obtain the acceleration data from the acceleration sensor; and determine, based on the acceleration data, that the medical device has flipped.

Abstract: In its many embodiments, the present invention provides certain substituted aryl and heteroaryl ether compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

Abstract: This document discusses a computer-implemented method of machine recognition of a physiological condition of a subject. The computer-implemented method comprises obtaining a video stream of the subject using a video data source; identifying, using processing circuitry, one or more areas within image frames of the video stream that contain a physiological feature of the subject; analyzing video data of the identified one or more areas in the image frames using the processing circuitry to detect change of the physiological feature between a first frame of video data and a later frame of video data; determining one or more change parameters of the physiological feature from the video data; and generating an indication of a symptom of Parkinson's Disease according to a detection criterion applied to the one or more change parameters.

Abstract: Systems and methods for detecting cardiac arrhythmia are discussed. An exemplary medical-device system includes an arrhythmia detector circuit that receives physiologic information, including respiration and heart beat information a patient, and determines whether a respiratory sinus arrhythmia (RSA) is present or absent using the respiration and the heart beat information. An indication of the presence or absence of RSA may be stored in a memory. The arrhythmia detector circuit can detect an AT episode using the indication of RSA.