Patents by Inventor Jonathan Edelson

Jonathan Edelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10016451
    Abstract: The present invention provides nanoparticle compositions including one or more nucleic acids. The present invention achieves delivery (particularly transdermal delivery) of such nucleic acids without the need for nucleic acid modification, or for use of chemical or mechanical abrasion or disruption of skin.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: July 10, 2018
    Assignee: Anterios, Inc.
    Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
  • Publication number: 20170312210
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Application
    Filed: July 7, 2017
    Publication date: November 2, 2017
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Publication number: 20170181952
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Application
    Filed: October 7, 2016
    Publication date: June 29, 2017
    Inventors: Jonathan EDELSON, Robert NICOLOSI
  • Patent number: 9649266
    Abstract: The present invention provides antagonists of acetylcholine receptors for the treatment of skin conditions. The present invention achieves treatment of skin conditions without causing the severe damage to the skin associated with antagonism of nicotinic acetylcholine receptors.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: May 16, 2017
    Assignee: Anterios, Inc.
    Inventor: Jonathan Edelson
  • Publication number: 20170087088
    Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis, among others. Methods generally involve administering provided compositions to the skin.
    Type: Application
    Filed: December 14, 2016
    Publication date: March 30, 2017
    Inventors: Jonathan Edelson, Timothy Kotyla, Klaus Theobald
  • Publication number: 20170079895
    Abstract: The present invention provides nanoparticle compositions including one or more peptides. The present invention achieves transdermal delivery of such peptides without the need for peptide modification, or for use of chemical or mechanical abrasion or disruption of skin.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 23, 2017
    Inventors: Jonathan Edelson, Timothy Kotyla
  • Patent number: 9486408
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: November 8, 2016
    Assignee: University of Massachusetts Lowell
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Patent number: 9486409
    Abstract: The present invention provides nanoparticle compositions including one or more peptides. The present invention achieves transdermal delivery of such peptides without the need for peptide modification, or for use of chemical or mechanical abrasion or disruption of skin.
    Type: Grant
    Filed: February 22, 2014
    Date of Patent: November 8, 2016
    Assignee: Anterios, Inc.
    Inventors: Jonathan Edelson, Timothy Kotyla
  • Publication number: 20160213757
    Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.
    Type: Application
    Filed: August 26, 2015
    Publication date: July 28, 2016
    Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
  • Patent number: 9233752
    Abstract: A drive system with harmonic drive designed to meet the high power and torque requirements required to drive an aircraft independently on the ground is provided. The drive system includes an electric motor driven by a harmonic drive assembly that may be configured to be integral with the motor. This drive system with harmonic drive can be effectively installed in an existing aircraft nose wheel or main wheel without changes to other components.
    Type: Grant
    Filed: July 29, 2012
    Date of Patent: January 12, 2016
    Assignee: Borealis Technical Limited
    Inventors: Hans Walitzki, Jonathan Edelson, Rodney T. Cox, Isaiah W. Cox
  • Publication number: 20150313819
    Abstract: The present invention provides antagonists of acetylcholine receptors for the treatment of skin conditions. The present invention achieves treatment of skin conditions without causing the severe damage to the skin associated with antagonism of nicotinic acetylcholine receptors.
    Type: Application
    Filed: May 1, 2015
    Publication date: November 5, 2015
    Inventor: Jonathan Edelson
  • Publication number: 20150313536
    Abstract: The present invention provides methods for improving observed or determined efficacy by administration of agents to more severely diseased subjects, as contrasted with less severely diseased subjects. The present disclosure specifically demonstrates that, with respect to treatment of certain skin conditions, and particularly conditions associated with dysregulated and/or diseased skin cells, administration to more severely diseased subjects improves observed or determined efficacy.
    Type: Application
    Filed: May 1, 2015
    Publication date: November 5, 2015
    Inventor: Jonathan Edelson
  • Publication number: 20150196490
    Abstract: The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions associated with the epidermal and/or dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, actinic keratosis, facial wrinkles, muscle contracture, and headache. Methods generally involve administering nanoparticle compositions to the skin.
    Type: Application
    Filed: January 16, 2015
    Publication date: July 16, 2015
    Inventors: Jonathan Edelson, Timothy Kotyla, Klaus Theobald
  • Patent number: 9033273
    Abstract: An aircraft ground control system that moves an aircraft on the ground between landing and take off without external mechanical assistance from airport tugs or tow vehicles or reliance on thrust produced by the aircraft's engines is provided. The aircraft ground control system interfaces only with an aircraft auxiliary power unit or other aircraft power supply, but otherwise operates independently of aircraft systems. A system integrator and controller links cockpit controls designed to actuate the transmission of power to system components and to activate system components only under predetermined conditions with selectively activatable drivers in driving connection with one or more aircraft wheels to move the aircraft on the ground at selected torques and speeds.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: May 19, 2015
    Inventors: Jonathan Edelson, Neal Gilleran, Isaiah Cox, Scott Perkins, Robert Sweet
  • Patent number: 9022316
    Abstract: A failsafe system and method for ensuring the safe operation of an aircraft with a ground movement system to drive the aircraft independently on the ground is provided. The system includes at least one aircraft nose or main drive wheel powered by an onboard wheel driver responsive to sensed aircraft and ground movement system operating parameters to continue operation in response to parameters within normal limits or to prevent continued operation if sensed parameters are outside normal limits and indicate continued operation to be unsafe. The onboard wheel driver includes a locking assembly responsive automatically or manually to signals indicating sensed parameters to lock the onboard wheel driver in an activated or an inactivated condition, depending on whether operation of the ground movement system can be continued safely.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: May 5, 2015
    Assignee: Borealis Technical Limited
    Inventors: Neal Gilleran, Robert Sweet, Jonathan Edelson, Isaiah Watas Cox
  • Patent number: 8820675
    Abstract: The invention disclosed is a self-propelled aircraft undercarriage for driving an aircraft on the ground, comprising: an axle; a strut supporting said axle; at least one wheel rotatably mounted on said axle; and drive means for driving said at least one wheel; characterized in that said drive means is disk shaped and is external to said wheel. In one embodiment of the invention, said drive means is mounted on said axle between said strut and said wheel. In a second embodiment, said drive means is mounted on said axle, on the side of said wheel furthest from said strut.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: September 2, 2014
    Inventors: Isaiah W. Cox, Hans J. Walitzki, Jonathan Edelson
  • Publication number: 20140234382
    Abstract: The present invention provides nanoparticle compositions including one or more peptides. The present invention achieves transdermal delivery of such peptides without the need for peptide modification, or for use of chemical or mechanical abrasion or disruption of skin.
    Type: Application
    Filed: February 22, 2014
    Publication date: August 21, 2014
    Applicant: Anterios, Inc.
    Inventors: Jonathan EDELSON, Timothy KOTYLA
  • Publication number: 20140099342
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Application
    Filed: October 9, 2012
    Publication date: April 10, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS LOWELL
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Patent number: 8658391
    Abstract: The present invention provides methods for assessing the activity of topically administered chemodenervating agents. In some embodiments, methods for assessing the activity of topically administered chemodenervating agents involve determining the extent of inhibition of acetylcholine release near the site of administration. In some embodiments, methods for assessing activity of topically administered chemodenervating agents involve observing a reflex motion of a limb of a subject.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: February 25, 2014
    Assignee: Anterios, Inc.
    Inventor: Jonathan Edelson
  • Patent number: 8505308
    Abstract: A starter/generator machine for a turbine with a turbine enclosure, an air duct, and a plurality of fan blades is provided. The starter/generator machine includes a plurality of stator elements spaced at intervals in a ring shape adjacent to the air duct and a plurality of rotor elements mounted on the fan blades. The stator elements and the rotor elements are mounted to interact magnetically to exert a force sufficient to move the rotor elements. The stator elements are shaped to minimize air flow interference and are formed with a core, at least one pole, and multiple windings. The spacing between the stator elements and the rotor elements forms an air gap on the order of 5-10 mm, and the number of stator elements is different from the number of rotor elements.
    Type: Grant
    Filed: April 1, 2012
    Date of Patent: August 13, 2013
    Assignee: Borealis Technical Limited
    Inventors: Hans Walitzki, Jonathan Edelson, Rodney T. Cox